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Dr. Peter Attia: Supplements for Longevity & Their Efficacy

Huberman Lab

NOTE

Caloric Restriction: Trade-offs in Health

Caloric restriction may significantly lower the risk of chronic diseases such as cardiovascular disease, cancer, and Alzheimer's by reducing calorie intake by about 25%. However, this approach raises concerns regarding potential negative impacts on the immune system, increased susceptibility to frailty, sarcopenia, and the possibility of higher risks of falling. While there is evidence suggesting that caloric restriction can lead to reduced chronic disease incidence, the direct correlation to increased lifespan is debated and not firmly established. Animal studies indicate that not all strains show longevity benefits from caloric restriction, highlighting the complexities and potential trade-offs involved in this dietary strategy.

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