High CO2 levels can lead to a decline in test results, eye irritation, sore throats, and other health issues. Levels over 800 to 1000 parts per million can potentially cause problems such as bone demineralization, kidney calcification, and chronic inflammation. CO2 levels exceeding 1000 can lead to serious issues with cognitive and physical function. Schools with CO2 levels of 1500 to 2000 have shown a 50% decrease in student test results.

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