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Everything you need to know about metabolic health | Metabolic Health Masterclass

The Proof with Simon Hill

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Muscle Resilience and Insulin's Role in Metabolism

The twin-cycle hypothesis integrates various observations about the body's food processing and metabolism, particularly in relation to type 2 diabetes. Muscle tissue exhibits significant resistance to insulin, which can be quantitatively assessed using advanced MRI technology to measure glycogen levels. Individuals with normal insulin sensitivity can store a substantial amount of dietary glucose as muscle glycogen shortly after eating, while those with insulin resistance fail to store glucose effectively, leading to glucose conversion into fat by the liver. This process results in increased fat accumulation in the liver due to improper glucose handling.

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