Reduced Risk of Alzheimer's Disease with Estrogen Replacement

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Estrogen replacement therapy taken before the final menstrual period or within 10 years after, results in a 32% reduction in the risk of Alzheimer's disease for women with surgical menopause. This reduction in risk was consistent across studies. However, taking estrogen more than 10 years after surgery has no effect on Alzheimer's risk. For women with a uterus, taking estrogen and progesterone for menopause or within 10 years reduces the risk by 23%. Beyond this timeframe, there may be an increased risk. The Women's Health Initiative study plays a significant role in understanding the impact of estrogen replacement therapy on Alzheimer's risk.

Lisa Mosconi, PhD, is an associate professor of neuroscience in neurology and radiology at Weill Cornell Medicine and the director of the Women’s Brain Initiative and the Alzheimer’s Prevention Clinic at Weill Cornell Medicine/NewYork-Presbyterian Hospital. Her latest book, The Menopause Brain: New Science Empowers Women to Navigate the Pivotal Transition with Knowledge and Confidence, is out now.

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