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Calories Matter More Than Source in Liver Fat Accumulation
The impact of fructose and saturated fat on liver fat depends on calorie intake. In studies with equal calories, overfeeding fructose increased liver fat by 16%, whereas overfeeding saturated fat increased it by 86%. When it comes to concerns about fructose and inflammation, studies show neutral or positive effects when polyunsaturated fats are added. Understanding the research requires looking beyond biochemical pathways to consider the overall study design and calorie balance.