The cholesterol theory of heart disease originated with Ansel Keys, who received significant research funding from Proctor & Gamble and propagated the idea that cholesterol causes heart disease. This theory was supported by a synergy of interest between the oil industry and Keys, who influenced nutrition thought in the American Heart Association. The speaker questions trusting the theory based on the questionable characters involved and the profit motives at play, suggesting a deeper dive into the science is warranted before blindly accepting such claims.

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