Insulin injections can cause weight gain in both Type 1 and Type 2 diabetics. Insulin instructs fat cells to grow and decreases metabolic rate, leading to weight gain. This phenomenon is observed even when Type 2 diabetics start insulin therapy. While it may be necessary for Type 1 diabetics to regain weight, it can be problematic for Type 2 diabetics who are already overweight. Overall, insulin therapy often leads to weight gain.

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