3min snip

The Peter Attia Drive cover image

#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

The Peter Attia Drive

NOTE

The Relationship Between M-Tor Activation, Amino Acids, and Muscle Mass

The importance of M-Tor in nutrient sensing and muscle mass is highlighted, along with the risk of sarcopenia. However, blocking M-Tor can also extend lifespan. The optimal level of M-Tor activity is necessary for the body's functioning. Surprisingly, rapamycin treatment can preserve muscle mass in rats and mice, although the explanation is unclear. It is speculated that the dosage plays a role. The effects of rapamycin on muscle building in humans and rodents are yet to be determined.

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