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CBD and Anxiety
CBD affects genetic susceptibility to anxiety through the endocannabinoid genes. Taking too much CBD can potentially lead to anxiety, as it blocks the cannabinoid one receptor. However, CBD is generally a good supplement that can increase natural endocannabinoids and is beneficial in the long run. When supplementing with GABA for a COMT AA genetic variant, it is important to consider the specific variant and whether GABA is being stimulated or taken as a supplement. Targeting the COMT directly and considering Sam E as a co-factor may be more effective. As for the individual taking ashwagandha, your graph, astragalus, 5 HGP, and GABA, it is unclear which supplements would be more efficacious.