Dr. Yoo Mee Shin shares practical tips for managing patients with sickle cell disease in the hospital. Topics discussed include acute pain management, adjuvant therapies, IV fluids, oxygen therapy, acute chest syndrome, and simple vs exchange transfusions. Key takeaways include early triage and analgesia, addressing misconceptions about opioid use disorder, and recognizing complications of vaso-occlusive crises.

Dr. Arielle Langer, an expert in antiphospholipid syndrome, discusses clinical features, laboratory testing, and management of the syndrome. Topics include suspicion for antiphospholipid syndrome, interpreting laboratory testing, managing recurrent thrombosis, and obstetric APLS. The challenges of diagnosing APS based on pregnancy history are also explored. Importance of referring patients to specialists and promoting support is emphasized.

Dr. Xiao Jing (Iris) Wang from Mayo Clinic joins to discuss disorders of the Gut-Brain Interaction (DGBI), including IBS, functional dyspepsia, and cyclic vomiting. Topics include diagnostic criteria and treatments for functional dyspepsia, testing algorithms and treatments for irritable bowel disease, and diagnosis and management of cyclic vomiting syndrome and cannabis hyperemesis syndrome.

The podcast covers a range of interesting topics including menopause therapy, hemochromatosis, hematuria management, diabetes updates, xylazine overdose and withdrawal, primary aldosteronism, resistant hypertension, delirium, AKI risk, statin therapy in HIV patients, inpatient heart failure management, kratom use implications, and effectiveness of RSV vaccines.

Dr. Carl Pallais, an expert in Hypercalcemia, discusses the regulation of calcium in the body and what happens when it goes wrong. Topics covered include the importance of PTH and phosphorus, causes of hypercalcemia, testing for hypercalcemia, symptoms and history, indications for surgery, and management of hypercalcemia.

Dr. Joel Topf, Kashlak's esteemed Chief of Nephrology, discusses the evaluation and differentiation of nephrotic syndrome and glomerulonephritis. Topics include proteinuria evaluation, management of nephrotic syndrome, and treatment of glomerulonephritis.

Guest Dr. Mohleen Kang from Emory University joins the hosts to discuss sepsis recognition, initial management, sepsis scoring systems, diagnostic work-up, antibiotic management, fluids, pressors, and supportive measures for sepsis patients. They emphasize the importance of gathering patient information, evolving sepsis definitions, clinical diagnosis and imaging, antibiotic selection, prioritizing antibiotics for skin infections, management of sepsis, and identification and treatment of sepsis.

Drs. Paul Williams and Nora Taranto discuss semaglutide for HFpEF and obesity, TCAs for IBS, clopidogrel vs aspirin after PCI, pitavastatin in HIV, weight changes and diet, and heavy metal exposure in cannabis users.

Dr. John Wong, an expert in PrEP for HIV Prevention, discusses the updated USPSTF guidelines on PrEP. They cover topics such as defining increased risk for HIV, counseling pearls, types of PrEP, safer sex practices, and HIV and STI screening on PrEP.

A discussion with Dr. Ilan Schwartz, an expert in fungal infections, covers topics like when to worry about fungal infections, starting anti-fungals, testing basics, resistant candida, and Pneumocystis jiroveci pneumonia. The episode also touches on MRI priorities for surgeons, unique holiday gifts, and the challenges of treating Candida and Canada-Oris.