The Curbsiders Internal Medicine Podcast

This grand overview of granulomas will leave you comfortable tackling an often breathtaking disease, sarcoidosis. Listen as our esteemed guests Dr. Mary Beth Scholand (University of Utah) and Dr. Jonathan Boltax (University of Utah) rheum-inate on sarcoidosis. We discuss the pathophysiology, diagnosis, and treatment of this disease, role of the primary care clinician and why sarcoidosis in the chart reminds Paul of Shakespeare.  Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Producer: Cyrus Askin MD and Deborah Gorth Writer: Deborah Gorth Infographic and Cover art: Edison Jyang Hosts: Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP    Editor: Cyrus Askin MD (written materials); Clair Morgan of nodderly.com Guest: Drs. Mary Beth Scholand & Jonathan Boltax Sponsor: ACP’s MKSAP MKSAP® is the most trusted resource for lifelong learning and Board prep for internal medicine physicians and residents. Learn more at acponline.org/mksap19 and use promo code CURB2021 at checkout. Sponsor: birch by Helix Visit birchliving.com/curb CME Partner: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org. Time Stamps 00:00 Intro, disclaimer, guest bio, Awful(ly good?) Pun 03:42 Guest one-liners 06:28 Sponsor - ACP’s MKSAP19 07:40 Case from Kashlak 08:40 Explaining sarcoidosis 12:19 Possible drivers of sarcoidosis 13:30 Taking a sarcoidosis history 17:26 Suggestions for catching sarcoidosis 21:44 Sponsor - birchliving.com/curb 23:52 Sarcoidosis physical exam, Diagnosis 33:00 Lofgren’s and Heerfordt’s syndromes; Imaging for sarcoidosis 40:44 Initiating therapy for sarcoidosis; Prognosis; the Treatment team 51:23 Primary care considerations for sarcoidosis  54:55 Diagnosing and treating a sarcoidosis exacerbation 61:20 Take home points and outro

Fresh hotcakes! Practice changing articles that you need to know: low dose colchicine for stable CAD; colchicine vs naproxen for acute gout flares; and physical therapy vs glucocorticoid injection for chronic Knee osteoarthritis. We’re joined by Michael Sternberg (Chief resident, VCU Internal Medicine Residency) and our fearless leader of critical appraisal, internist/epidemiologist, Rahul Ganatra MD, MPH, @rbganatra (VA Boston).  Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Written and Produced by: Matthew Watto MD, FACP Cover Art: Matthew Watto MD, FACP Hosts: Rahul Ganatra MD, MPH; Michael Sternberg MD; Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP    Editor: Matthew Watto MD (written materials); Clair Morgan of nodderly.com Sponsor: ACP’s MKSAP18 MKSAP® is the most trusted resource for lifelong learning and Board prep for internal medicine physicians and residents. Learn more at www.acponline.org/curb2021. CME Partner: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org . Time Stamps Intro, disclaimer 01:45 Fun animal fact; Picks of the Week* 06:33 PT vs steroid injection for chronic knee OA 21:00 Colchicine for stable CAD 33:00 Low dose colchicine vs naproxen for acute gout flares

Listen as our esteemed guest Dr. Wanpen Vongpatanasin, @DrWanpen (UT Southwestern) discusses the nitty-gritty of blood pressure monitoring and hypertension treatment.  We review the thresholds for HTN diagnosis and how to accurately measure blood pressure levels at home and in the office.  Dr Vongpatanasin shares the latest guideline recommendations for first line pharmaceutical therapies as well as her pearls about how to treat special populations. Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Produced by: Deborah Gorth and Isabel Valdez, PA Written by: Deborah Gorth  Infographic and Cover Art: Edison Jyang Hosts: Stuart Brigham, MD; Matthew Watto, MD, FACP; Paul Williams, MD, FACP    Editor: Molly Heublein, MD (written materials); Clair Morgan of nodderly.com Guest: Wanpen Vongpatanasin, MD Sponsor: ACP’s MKSAP18 MKSAP® is the most trusted resource for lifelong learning and Board prep for internal medicine physicians and residents. Learn more at www.acponline.org/curb2021. Sponsor: Provider Solutions and Development Provider Solutions & Development is a community of experts dedicated to offering guidance and career coaching to physicians and clinicians throughout their entire career journey. With exclusive access to hundreds of opportunities across the nation, reach out today to begin the search for your perfect practice: www.psdrecruit.org/curbsiders. CME Partner: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org. Time Stamps 00:00 Sponsors, Intro, disclaimer, guest bio 03:20 Guest one-liner 05:50 Sponsor - ACP’s MKSAP 18 07:05 Case from Kashlak; Defining hypertension and treatment thresholds 10:43 Measuring blood pressure (at home, in the office, validatebp.org) 16:46 Wrist BP cuff 19:50 Home monitoring and ambulatory BP monitoring; What time to take BP medication 31:23 Sponsor - Provider Solutions and Development 32:10 Approach to treatment; Combo pills; How to titrate meds 42:20 Treating resistant hypertension; hyperaldosteronism; Isolated systolic hypertension 52:04 Take home points and Outro

Answer all your burning questions (and your patients’ burning questions) about the different COVID-19 vaccines currently authorized in the US. Infectious diseases / HIV expert, Dr Monica Gandhi @MonicaGandhi9 (UCSF) joins us to cover: the Pfizer-BioNTech and Moderna novel mRNA vaccine mechanisms, trial data, and practicalities of who should receive them.  We discuss data around the Oxford-AstraZeneca adenovirus vaccine, which is authorized in the UK and India, and may be available in the US later this year.  Feel confident recommending COVID-19 vaccines to your patients! Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Written and Produced by: Molly Heublein, MD Cover Art: Chris Chiu, MD, FACP, FAAP Infographic: Tima Karginov Hosts: Chris Chiu, MD, FACP, FAAP; Molly Heublein, MD; Paul Williams, MD, FACP Editor: Emi Okamoto MD (written materials); Clair Morgan of Nodderly.com (audio) Guest: Monica Gandhi, MD, MPH Sponsor: Panacea Financial  This episode is supported by Panacea Financial, digital banking built for doctors, by doctors. At Panacea Financial you can have your own free personal banker and a support team that works around the clock- just like you do. Open your free checking account today at panaceafinancial.com Panacea Financial, a Division of Sonabank, Member FDIC Sponsor: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org. Time Stamps Intro, disclaimer, guest bio - 00:00  Guest one-liner, book recommendation - 3:40 Authorized vaccines in the US - 8:30 AstraZeneca vaccine mechanism- 9:26 mRNA vaccine mechanism - 10:30 Vaccine distribution issues (cold chain) - 16:05 mRNA safety - 18:24 mRNA vaccine efficacy/data from phase 3 trials - 19:40 How did we get this so quickly - 23:40 Vaccine impact on asymptomatic infection - 26:18 AstraZeneca trials - 28:20 Pregnancy - 35:10 Anaphylaxis - 37:10 Prior COVID-19 infection - 39:07 Side effects - 42:05 Pediatric patients - 45:12 Phases of role outs in the US -46:50 Herd immunity - 48:16 Thoughts of how to make this happen - 52:45 Preexisting conditions - 53:40 How long will immunity last - 57:15 Mutant strains - 58:25 Future of mRNA vaccines - 1:00:30 Take home points and Outro - 1:02:12

Get all the details on varenicline, nicotine replacement therapy, and integrating psychosocial interventions into a comprehensive smoking cessation treatment plan! Smoking cigarettes is the leading cause of preventable death worldwide. Listen as our esteemed guest Dr. Steve Baldassarri (Yale) provides us expert pearls to help our patients quit smoking.  Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Written and produced by: Carolyn Chan, MD Infographic: Edison Jyang Cover Art: Kate Grant Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Editor: Cyrus Askin, MD (written materials); Clair Morgan of nodderly.com Guest: Steve Baldassarri MD MHS Sponsor: The American College of Physicians Join us for ACP Internal Medicine Meeting 2021: Virtual Experience for 3 days of interactive, livestreaming education and events April 29 through May 1—plus on-demand post-meeting access to CME credit for up to 3 years.   “Early Bird” members get an additional $80 registration discount on top of their member discount. Visit annualmeeting.acponline.org. (Prices shown online at registration pages reflect Discounted Rates.)   Register now—Early Bird savings end January 31st! Sponsor: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org. Time Stamps* *Note: Time Stamps refer to ad free version.  03:02 Intro, disclaimer, guest bio 04:35 Guest one-liner  09:50 Tobacco Use Disorder - Chronic Disease 11:08 Case from Kashlak 11:56 Obtaining a history 13:39 Motivations for Smoking Cessation 15:29 Factors associated with challenges in smoking cessation: 21:40 Gradual Tapers vs Cold Turkey 25:18 Nicotine Replacement 32:40 28:57 Pharmacotherapy - “Controller” Medications 31:05 Pharmacotherapy - Short Acting Medications 33:20 Dosing Medications 38:35 Varenicline 39:00 Nicotine gum dosing  44:40 Duration of therapy 48:08 Bupropion  49:05 Behavioral Interventions 55:24 Vaping and electronic cigarettes  57:03 Vaping for smoking cessation 01:02:35 EVALI 01:05:49 Outro

What the USPSTF?! It’s time for some preventive medicine updates on: screening for unhealthy drug use, cervical cancer, hepatitis C and draft recs for colorectal cancer; plus how to interpret USPSTF screening recs. Dr. Amber-Nicole Bird @ABirdMD (Penn Medicine) refreshes our love for preventive medicine, with updates on the newest recommendations. She reviews how to appropriately interpret and adopt guidelines for our patients, being cognizant of the source. We shine light on the mechanism of USPSTF, including how their guidelines differ from others, so we can understand the value and context when utilizing the guidance in the clinic. Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Produced and Written by: David Madick MD; Peter Wikoff MD; Paul Williams MD, FACP Infographic: Beth Garbitelli Cover Art: Chris Chiu MD Hosts: Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Editor: Emi Okamoto, MD (Show notes); Clair Morgan of nodderly.com Guest: Amber-Nicole Bird, MD Sponsor: The American College of Physicians Join us for ACP Internal Medicine Meeting 2021: Virtual Experience for 3 days of interactive, livestreaming education and events April 29 through May 1—plus on-demand post-meeting access to CME credit for up to 3 years. “Early Bird” members get an additional $80 registration discount on top of their member discount. Visit annualmeeting.acponline.org and use the code IM21CURB. Register now—Early Bird savings end January 31st! Sponsor: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org.

Kashlak’s esteemed Chief of Nephrology, Dr Joel Topf @kidney_boy walks us through the evaluation and differentiation of nephrotic syndrome and glomerulonephritis. Embrace the kidney again as we sort the different diagnostics, managements, and prognosis for these two pathologies. Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Producer, writer, infographic, cover art: Elena Gibson MD Hosts: Elena Gibson MD, Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Editor: Emi Okamoto MD (written); Clair Morgan of nodderly.com (audio) Guest: Joel Topf MD Time Stamps* *Note: Time Stamps refer to ad free version Intro, disclaimer, guest bio – 00:00 Picks of the Week – 3:10 Case from Kashlak – 6:30 Nephrotic syndrome definition- 12:30 Proteinuria evaluation – 15:04 Additional lab testing – 27:08; 40:09 Types of Nephrotic syndrome – 30:15 Mechanism of nephrotic syndrome edema – 33:08 Management of nephrotic syndrome – 44:07 Second Kashlak Case- Glomerulonephritis – 55:05 Treatment of glomerulonephritis – 65:05 Outro and post-credits scene – 73:20 Sponsor: The American College of Physicians Join us for ACP Internal Medicine Meeting 2021: Virtual Experience for 3 days of interactive, livestreaming education and events April 29 through May 1—plus on-demand post-meeting access to CME credit for up to 3 years. “Early Bird” members get an additional $80 registration discount on top of their member discount. Visit annualmeeting.acponline.org and use the code IM21CURB. Register now—Early Bird savings end January 31st! Sponsor: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org and search for this episode to claim credit.

Recap the top pearls from recent shows on vulvovaginitis, cellulitis and bites, MGUS and the SPEP. Tales from the Curbside (TFTC) is pilot project providing a rapid review of recent Curbsiders episodes. Note: There is no CME for this mini-episode but visit curbsiders.vcuhealth.org to claim credit for #244, #246 and #247. Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Written, Produced and Hosted by: Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Infographics by: Kate Grant MBChb, MRCGP, Beth Garbitelli and Nora Taranto MD Cover Art: Matthew Watto Editor: Matthew Watto MD (written materials); Clair Morgan of nodderly.com Sponsor: The American College of Physicians Join us for ACP Internal Medicine Meeting 2021: Virtual Experience for 3 days of interactive, livestreaming education and events April 29 through May 1—plus on-demand post-meeting access to CME credit for up to 3 years. “Early Bird” members get an additional $80 registration discount on top of their member discount. Visit annualmeeting.acponline.org and use the code IM21CURB. Register now—Early Bird savings end January 31st! Time Stamps* *Note: Time Stamps refer to ad free versions. 00:00 Intro, disclaimer, guest bio 02:35 Vulvovaginitis 05:35 Cellulitis and Bites 09:45 SPEP it Up 15:15 Outro

Our team shares the top pearls of 2020 in our annual recap extravaganza featuring guest host, Chris “The Chiu Man” Chiu @cjchiu. Check out the video version at YouTube. Topics: hypothyroidism, women in medicine, hypothermia, diuretics, heart failure, AKI, lipids, post-op fever, refugee health, SGLT2 inhibitors, euglycemic DKA, UTIs, bat bites, rabies, ILD, statins in NAFLD, framework for hair loss, and more! Plus: Our picks of the year and the Curbsiders gift guide! Note: This episode is not available for CME but #208 through #247 are available for CME/MOC at curbsiders.vcuhealth.org for free! Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Producer: Chris Chiu MD, FACP, FAAP Written by: The Curbsiders Team Show Notes: Matthew Watto MD, FACP Cover Art: Chris Chiu MD, FACP, FAAP Hosts: Chris Chiu MD, FACP, FAAP, Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Editor: Matthew Watto MD (written materials); Clair Morgan of nodderly.com Sponsor: Panacea Financial This episode is supported by Panacea Financial, digital banking built for doctors, by doctors. At Panacea Financial you can have your own free personal banker and a support team that works around the clock- just like you do. Open your free checking account today at panaceafinancial.com Panacea Financial, a Division of Sonabank, Member FDIC

Dr. Jorge Castillo from Harvard and Dana Farber joins the hosts to discuss topics such as immunology basics, limitations of the SPEP, when to suspect MGUS and myeloma, and how to talk to patients about these conditions. They also touch on Waldenstrom's and amyloidosis, providing valuable clinical insights and diagnostic frameworks. Tune in to learn more about these fascinating topics in internal medicine.