#281 Hypercalcemia: Calci-fun! with Dr. Carl Pallais
Jun 28, 2021
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Dr. Carl Pallais discusses the management of hypercalcemia in this entertaining podcast. Topics covered include the importance of assessing lab results for calcium levels, interpreting calcium levels in the ambulatory setting, causes and effects of hypercalcemia, and the treatment of hypercalcemia including the use of medications and specific therapies. Stay tuned for interesting insights!
Hypercalcemia can be categorized into PTH-dependent and PTH-independent causes, with primary hyperparathyroidism being the most common cause of PTH-dependent hypercalcemia and hypercalcemia of malignancy being the main cause of PTH-independent hypercalcemia.
When evaluating a patient with hypercalcemia, repeat labs, including calcium, albumin, phosphate, PTH, and 25 OH vitamin D, are essential to determine the underlying cause and severity of the condition.
Management of hypercalcemia involves considering medications that may contribute to elevated calcium levels, evaluating lifestyle factors like calcium and vitamin D supplementation, and maintaining adequate hydration to prevent complications.
Deep dives
Classification of hypercalcemia
Hypercalcemia can be categorized into PTH-dependent and PTH-independent causes. Primary hyperparathyroidism is the most common cause of PTH-dependent hypercalcemia, while hypercalcemia of malignancy is the main cause of PTH-independent hypercalcemia.
Evaluation and Symptoms of Hypercalcemia
When evaluating a patient with hypercalcemia, repeat labs, including calcium, albumin, phosphate, PTH, and 25 OH vitamin D, are essential. Symptoms of hypercalcemia can vary depending on the severity and acuity of the condition, ranging from bone pain and kidney stones to gastrointestinal upset and even psychiatric symptoms like confusion or delirium.
Factors Affecting Treatment Decision
Factors that can influence the decision for surgical intervention in primary hyperparathyroidism include age less than 50, high calcium levels, renal dysfunction, history of kidney stones, and presence of asymptomatic stones. Imaging studies, such as renal ultrasound, can help detect asymptomatic kidney stones.
Considerations for Medications and Lifestyle
When managing hypercalcemia, it is important to consider medications that may contribute to elevated calcium levels, such as lithium and thiazide diuretics. Lifestyle factors like calcium and vitamin D supplementation should be evaluated and adjusted accordingly. Adequate hydration is crucial to prevent complications associated with hypercalcemia.
Importance of Assessing for Asymptomatic Kidney Stones and Bone Loss
When evaluating patients, it is crucial to assess for asymptomatic kidney stones and bone loss. For kidney stones, a renal ultrasound is recommended to look for asymptomatic stones. Similarly, for bone loss, a bone density test should be performed, including an assessment of the wrist, in addition to the spine and hip. The goal is to identify and treat these conditions early to prevent further complications.
Managing Hypercalcemia: Fluids and Medications
In cases of severe hypercalcemia, prompt action is essential. Normal saline or lactated Ringer's solution can be used to provide volume and promote calcium excretion through the kidneys. Loop diuretics may be considered to enhance fluid removal, but caution should be exercised to avoid dehydration. Specific treatments, such as calcitonin and antiresorptive medications like zoledronic acid or denosumab, can be used to target calcium release from bones. For cases related to malignancy, further workup and tailored treatments may be necessary.
Absorb all (but not too much) of the Calcium for your brain hole as Dr. Carl Pallais (Brigham and Women’s Hospital) walks us through his approach to Hypercalcemia. We learn about how tightly our body regulates calcium, and what to do when that regulation goes awry. Not to mention that, at the end of the day, PTH is the name to remember (and phosphorus, if you need a quick stand-in while that PTH is pending).
CME Partner: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org .
Show Segments
Intro, disclaimer, guest bio
Dr. Pallais One-Liner
Case from Kashlak
Definitions: What’s a Normal Calcium Level, and how to adjust for Albumin
Causes of hypercalcemia
How Lithium works!
Testing for Hypercalcemia: Get that PTH, and that phos
Symptoms of Hypercalcemia, and Questions on History
Indications for Surgery for Parathyroidectomy
Management of Hypercalcemia and Hypercalcemic Emergency
Outro
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