LONGEVITY with Nathalie Niddam

My guest this week is Ryan Smith, VP of Business Development at TruDiagnostic. In this episode, Ryan and I discuss how TruDiagnostic got started, the services they offer and more!   Learn more about TruDiagnostic at https://trudiagnostic.com/. Use promocode longevity12 for 12% off.   Ryan Smith attended Transylvania University and graduated with a degree in Biochemistry. After finishing all the educational curriculum and passing USMLE Step 1 he decided to leave and open up a pharmacy in the United States that focused on peptide synthesis and formulations for pharmaceutical preparations. That pharmacy, Tailor Made Compounding, became the 4th fastest growing company in healthcare in the US. Ryan exited Tailor Made in late 2020. Since then, Ryan has opened many businesses including TruDiagnostic, a company focusing on methylation array-based diagnostics for life extension and preventive healthcare. TruDiagnostic is a CLIA certified lab and health data company focused on serving integrative and functional medicine providers in the United States. TruDiagnostic has a commitment to research with over 21 approved clinical research studies investigating the epigenetic methylation changes of a variety of longevity and health interventions. Since Tru Diagnostics inception, they have created one of the largest private epigenetic health databases in the world with over 13,000 patients tested.   Follow Ryan Smith at TruDiagnostic https://trudiagnostic.com/ Instagram @trudiagnosticofficial Facebook  Youtube  Episode Sponsor: drinkHRW.com To get the most out of any therapy it is crucial to address the foundations of health.  Molecular Hydrogen addresses  these foundations through its ability to help to manage reactive oxygen species (ROS), inflammation and improve metabolic balance.  I drink molecular hydrogen water every morning before anything else and have my clients do the same.  Anecdotally we have seen improvements in blood sugar control, pain from arthritis and even cognitive function in a Parkinson’s patient.  Ongoing research is demonstrating the many ways that molecular hydrogen can support human health.      Use promo code longevity10 for 10% off at https://drinkhrw.com/   Episode Takeaways [07:30] How long have we been able to do epigenetic methylation testing for the average consumer?.. [08:40] What brought Ryan to where he is today?.. [13:47] What is epigenetics?  [16:15] What is the difference between the TruDiagnostic test and MTHFR genetic testing? [19:35] Establishing biological age vs chronological age... [23:26] The link between methylation and age.. [28:20] Dunedin Study.. [33:50] Is there anything you can do to slow the rate of aging or is it predetermined?.. [39:29] The impact of stress and cortisol on aging. Is DHEA the key to anti-aging?.. [41:35] Is higher growth hormone and higher IGF1 detrimental to aging or anti-aging? [46:40] The effect of a mothers stress on her fetus. How much of aging is genetic?.. [49:47] What are the different reports that TruDiagnostic offers? [55:00] Studies on the effect of COVID and the COVID vaccine on epigenetics.. [58:00] Smoking and drinking, how they affect epigenetics.. [64:00] Creating personalized plans based on epigenetics.. [68:53] Are there ways to reverse epigenetic aging caused by bad habits such as smoking?.. [72:02] Is TruDiagnostic tracking the effect of bioregulator peptides and other supplements on genes?.. [77:15] How does TruDiagnostic run their tests and how do they know if you are doing a good epigenetic test?.. Linkage https://trudiagnostic.com/   use promocode longevity12 for 12% off.     Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.

In this week’s episode, Nathalie talks to Dr. Sandy Kaufmann the seven tenets of aging, 3 of the amazing compounds she has included in her upcoming new book and how to stay young as you get older!   Meet This Week’s Guest Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master’s Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital, a nationally recognized center of excellence. Most recently, she was recognized as “Best in Medicine” by the American Health Council. Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging.   Episode Sponsor:  Oxford HealthSpan brings us Primeadine, the best formulated Spermidine supplement on the market!  What makes it stand out – it includes Spermine & Putrescine two other Polyamines that work hand in hand with Spermidine PLUS FOS, a prebiotic to feed the bacteria in your gut that make Spermidine!  I take Spermidine daily as do my family and my clients – it has become a solid member of my “foundation stack”.  Research has shown that Spermidine upregulates autophagy, helps the immune system to rejuvenate and it protects DNA – visible benefits experienced by myself and my clients include better sleep, hair, skin and nails!  If you haven’t tried it yet go to Primeadine.com and use promo code BIONAT15 to save 15%.   Key Takeaways [03:40] About Dr. Kaufmann... [06:20] The seven tenets of aging: Information Systems (DNA), Cellular Energy, Cellular Pathways, Quality Control, Immune System, Individual Cells, Waste Management… [14:07] Should you do an aggressive heavy metal detox?.. [16:21] Should we all be taking prenatal vitamins?.. [19:28] The ranking system of the seven tenets of aging covered in the Kaufman Protocol [24:28] About the Kauffmann protocol app… [27:30] Should you stay on supplements indefinitely or cycle them?.. [28:35] What supplements are the foundational supplements most people should be on?.. [38:12] Thoughts on vitamin D3?.. [38:46] Teaser of Dr. Kaufmann’s second book. How is the book organized? Can you use the book like a health encyclopedia?.. [42:00] Ecklonia cava, the key to weight loss, healthy skin and hair?.. [53:30] Reishi mushrooms, the key to immortality? [62:00] Spermidine, the one of a kind supplement that fills in all the gaps [74:00] What are the best brain supplements? [78:55] What are the best antiaging tips that do not involve supplements?   Linkage: Website: https://kaufmannprotocol.com/ Instagram: @Kaufmannantiaging     Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.    

In this week’s episode, Nathalie chats with Jean-François Tremblay start the conversation with  LL37 – a powerful antimicrobial peptide naturally synthesized in humans.  They then move on to a new hybrid peptide bringing Thymosin Alpha 1 and LL37 – designed to potentially mitigate the natural cytotoxic effects of LL37.   They then move on to the synthetic versions of the bioregulator peptides produced by CanLab and correct a commonly held misconception about proper dosing levels.  The good news is that Bioregulators just became a lot more affordable!  We then move on to GHK…and much much more!   Meet This Week's Guest Jean-Francois Tremblay is the owner of CanLab, a Montreal based company that specializes in synthesizing and manufacturing peptides. Jean-François Tremblay is a regular guest on this podcast.  Jean-Francois studied Exercise Physiology, Biochemistry, and Pharmacy at UQAM.  He has been researching (in theory and in practice) peptides and SARMS since the 90’s and has been studying the theoretical basis of what peptides are and their practical applications in sports performance, anti-aging, and health in general.    Episode Sponsor:  drinkHRW.com To get the most out of any therapy it is crucial to address the foundations of health.  Molecular Hydrogen addresses  these foundations through its ability to help to manage reactive oxygen species (ROS), inflammation and improve metabolic balance.  I drink molecular hydrogen water every morning before anything else and have my clients do the same.  Anecdotally we have seen improvements in blood sugar control, pain from arthritis and even cognitive function in a Parkinson’s patient.  Ongoing research is demonstrating the many ways that molecular hydrogen can support human health.     Use promo code Longevity10 to save 10% off your purchase at drinkHRW.com    Key Takeaways [03:35] Ll-37 can it possibly play a role in dealing with the current crisis? [07:13] Ll-37 to treat HIV… [08:00] Cytotoxicity (the dying of good cells) with ll-37. How can we mitigate that reaction? [09:08] Vitamin D levels and immunity; genetic variations that inhibit vitamin D conversion [11:23] How does air pollution effect health and natural ll-37 levels? [15:30] Ll-37/TA1 hybrid peptide.. What can it treat? Why does it work? [22:27] Dosing of ll-37/TA1 [28:00] Let’s talk bioregulator peptides.. Synthetic vs natural? Oral vs injection? [33:15] Dosing of synthetic vs natural bioregulator peptides [41:00] Is Epitalon an anti-cancer compound? [43:23] Bioregulator peptides and their effects on other organs… [47:30] Thymosin beta 4’s use in anti-aging and heart treatment... [51:00] Mots-C for energy and chronic fatigue.. [54:14] GHK and it’s effect on genetics, skin and more… What is the best protocol for GHK?.. [60:01] Insulin pumps for peptides?.. Check out https://canlabsciences.com/ and use Promocode OSP15 for your purchase   Linkage: Study discussed re Human Cathelicidin (LL37) & Covid19 Insulin Pump   DISCLAIMER:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.  Most peptides are classified as research chemicals and are not intended for human use – this podcast in no way is promoting or endorsing the personal use of peptides beyond research purposes.

In this week’s episode, Nathalie chats with Greg Kelly the director of product development at Neurohacker Collective. Their main focus is on the eyes, how modern life and the past year in particular have exerted an undue amount of pressure on visual health.   Enter Qualia Vision the latest entry in the impressive Neurohacker collection of formulas, we go through the science of protecting your eyes and what this formula has to offer.  We also touch on NAD and Qualia Life (how could we not!?) and Qualia Night – a nighttime nootropic for your brain, what he thinks is going on with the FDA regarding NAC and more!   To try any of the Qualia Products go to Neurohacker.com and use promo code NN15 to save 15%.   Meet This Week's Guest  Dr. Greg Kelly is a Naturopathic Doctor and the Director of Product Development at Neurohacker Collective, where he oversees development, research, and scientific support of supplement formulations.  He is an author and speaker in areas related to nootropics, biohacking, anti-aging, sleep, stress, weight management, exercise, and brain performance.Greg is an expert on nutrition, wellness, and preventive medicine, with a solution-minded approach to problems and a broad scope of experience, including clinical practice, nutraceutical research & formulation, classroom and online education, medical writing and publication, corporate wellness, medical claims’ analysis, and development of IT solutions.   Episode Sponsor Oxford HealthSpan brings us Primeadine, the best formulated Spermidine supplement on the market!  What makes it stand out – it includes Spermine & Putrescine two other Polyamines that work hand in hand with Spermidine PLUS FOS, a prebiotic to feed the bacteria in your gut that make Spermidine!  I take Spermidine daily as do my family and my clients – it has become a solid member of my “foundation stack”.  Research has shown that Spermidine upregulates autophagy, helps the immune system to rejuvenate and it protects DNA – visible benefits experienced by myself and my clients include better sleep, hair, skin and nails!  If you haven’t tried it yet go to Primeadine.com and use promo code BIONAT15 to save 15%.   Key Takeaways [02:50] How did Greg get to where he is today?.. [09:57] Is NAC a drug? Is the FDA really taking it off the market? [20:10- 36:00] Greg and Nathalie talk about everything eyes! Supplements for eyesight? How common is myopia? What is the best solution for myopia? What is the effect of technology and blue light on eyesight?.. Is beta carotene good for the eyes?.. [36:05] Qualia vision, what is in the product and why? [48:08] Could you use eyedrops as a supplement instead of an oral product for eye health? [50:50] Things you can do to mitigate stress on the eyes from screen time [57:15] More about Qualia vision. How many pills are needed per day? What testing is behind the product?.. [59:15] Qualia Life supplement for better aging. The active ingredients AND the ingredients that were left out and why [69:06] Studies on Qualia Life product [79:40] Greg and Nathalie touch on the Qualia Night the “nighttime nootropic” to wrap things up!   Linkage: Website: https://neurohacker.com Instagram: https://www.instagram.com/neurohacker/     Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.

In this week’s episode, Nathalie talks to Carlee Hayes the lead Dietitian at NutriSense about how CGM’s and the Nutrisense app can support individuals to personalize their diet and reach their goals.    We talk about the value, strengths and weaknesses of continuous glucose monitors.   And, how this app and strategy can support people trying to lose body fat as well as athletes and people trying to gauge their glycemic response to various foods.     Meet This Week's Guest Carlee is a Registered Dietitian Nutritionist (RDN) who specializes in bariatric nutrition therapy and weight loss. She graduated from Western Illinois University and has worked as a nutritionist at MultiCare Health Systems and Veterans Affairs.   Episode Sponsor:   drinkHRW.com – I drink molecular hydrogen water every morning before anything else and have my clients do the same.  Anecdotally we have seen improvements in blood sugar control, pain from arthritis and even cognitive function in a Parkinson’s patient.  The research on the many ways that molecular hydrogen can support human health continues to come in as evidence mounts on this important signaling molecule.  A human clinical *trial showed that drinking hydrogen water daily for 8 weeks had a positive impact on lipid and glucose metabolism in patients with T2D and Impaired Glucose Tolerance… important metrics in maintaining healthy weight.   Use promo code Longevity10 to save 10% on your purchase.   Key Takeaways [01:00] About Carlee Hayes… [04:30] What are CGM’s (continuous glucose monitors) and why are they useful?.. [08:09] Is traditional HbA1C testing flawed?.. [11:46] What is the value of CGM’s? Using CGM’s to find out how YOUR individual body adapts to different foods and activities… [14:33] What diet is right for me? How CGM’s can help you figure that out… [18:39] How much information does the NutriSense give you? Can it teach you how to eat based on the data you input?.. [21:47] Is blood sugar response different at different times of day? Is late night snacking that big of a deal?.. [24:27] Tracking blood sugar for better sleep?.. [32:00] Using CGM’s to optimize athletic performance… [38:35] What can you do to alter the way your body reacts to certain foods? Should you worry about blood sugar if weight is not an issue for you?.. [41:00] Are CGM’s inaccurate for some people? Can you be too thin to use a CGM? What is being done to ensure the most accuracy?..  [45:30] Is the NutriSense device painful? How do you apply it? [50:58] Carlee’s three biggest pieces of advice to get the most out of your blood sugar… [58:30] The effect of COVID on blood sugar…   Visit https://www.nutrisense.io/ to learn more about the NutriSense device!   Linkage Website: https://www.nutrisense.io/ Facebook: https://www.facebook.com/carlee.hayes57 Instagram: @carleeohayes LinkedIn: https://www.linkedin.com/in/carlee-hayes-rdn-cd-b64b65b1/   Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.

In this week’s episode, Dr Elizabeth Yurth is back on the podcast talking about fat loss in particular for stubborn cases where people just seem to get stuck…we talk about some of the newer options on the market including Semaglutide (Ozempic) and how an immune peptide – Thymosin Alpha 1 – may also play a role.  We also explore unconventional applications for various compounds including how a medication developed to treat arthritis might actually help with weight loss and how Semaglutide might also play a role in brain health.   As always, Dr. Yurth and Nathalie cover a lot of ground, enjoy the episode!   Meet This Week’s Guest Dr. Elizabeth Yurth is the Co-Founder and Medical Director of Boulder Longevity Institute. Dr. Yurth obtained her Medical Degree from the University of Southern California Keck School of Medicine and completed her residency at the University of California. Along with her 25 + years as a practicing orthopedist specializing in sports, spine, and regenerative medicine, Dr. Yurth is double-Board Certified in Physical Medicine & Rehabilitation and Anti-Aging/Regenerative Medicine. She has a Stanford-affiliated Fellowship in Sports and Spine Medicine, and a dual-Fellowship in Anti-Aging and Regenerative Medicine and Anti-Aging, Regenerative and Functional Medicine through the American Academy of Anti-Aging Medicine. Dr. Yurth has also completed a Fellowship in Human Potential and Epigenetic Medicine, is part of the first cohort of providers to receive the A4M National Peptide Certification, and is a faculty member and national lecturer for both A4M and the International Peptide Society.  She is a member of IPS’s very first Peptide Mastermind Group, comprised of a small elite group of national peptide experts. Dr. Yurth has completed over 500 hours of Continuing Medical Education (CME) training in the areas of Longevity, Epigenetics, Nutrition, Bioidentical Hormone Replacement Therapy, Regenerative Peptide Treatments, and Regenerative Orthopedic Procedures. As an athlete herself who has dealt with numerous injuries, Dr. Yurth is thrilled to share with her clients all the innovative, life-changing treatments that are on the cutting-edge of medicine.    Episode Sponsor:   drinkHRW.com – I drink molecular hydrogen water every morning before anything else and have my clients do the same.  Anecdotally we have seen improvements in blood sugar control, pain from arthritis and even cognitive function in a Parkinson’s patient.  The research on the many ways that molecular hydrogen can support human health continues to come in as evidence mounts on this important signaling molecule.  A human clinical *trial showed that drinking hydrogen water daily for 8 weeks had a positive impact on lipid and glucose metabolism in patients with T2D and Impaired Glucose Tolerance… important metrics in maintaining healthy weight.   Use promo code Longevity10 to save 10% on your purchase.   Key Takeaways [07:00] Using GLP-1 agonist’s for fat loss and obesity… [9:00] Semaglutide (Ozempic) may be the most effective GLP-1 antagonist - how does it work exactly? [14:00] Can Semaglutide help with brain health and even treat Alzheimer’s?  What are the mechanisms at play? [20:42] Optimizing digestion in order to increase results with GLP-1 agonist’s. Is digestion the key to improving a host of health issues? [25:33] Options for those people who truly cannot lose weight.  [29:35] Amlexanox the arthritis drug for weight loss – what gives? [31:40] Using Thymosin Alpha 1 for weight loss patients [36:38] Improving performance with Viagra and leucine [43:20] Fine-tuning dosage of GLP-1’s  for fat loss   Linkage: To connect with Dr Yurth: https://boulderlongevity.com To learn more about the courses she offers including “What to Fix First”: https://bli.academy/courses/ Instagram: https://www.instagram.com/dryurth/   Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.   *Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008 Mar;28(3):137-43. doi: 10.1016/j.nutres.2008.01.008. PMID: 19083400.

Are you looking to achieve metabolic flexibility? This is the episode for you then!   In this week’s episode, Nathalie talks to Daniel Tal about the Lumen device. Lumen measures metabolism in a single breath, in less than a minute, instead of an hour-long test in a lab. The technology uses CO2 from the breath to calculate whether the user is burning fats, carbs or some combination of the two – it then interfaces with an app to provide guidance and feedback with the goal of supporting users in developing “metabolic flexibility”. This is the perfect episode for those who are health focused, but don’t want to do a hardcore diet like Keto.   Meet This Week's Guest Daniel Tal! Daniel is a seasoned entrepreneur, co-founder, and CEO of Lumen, a company developing consumer nutrition management platform, based on a small device that measures metabolism in a single breath and provides personalized food, lifestyle, and health recommendations.   Episode Sponsor:  Oxford Healthspan manufactures the top Spermidine Supplement on the market – Primeadine.  Primeadine is a food-based supplement with an extremely high safety profile that halts 6 of the 9 hallmarks of aging.  It is the purest in the market, with zero fillers and a formulation that also supports the endogenous production of spermidine through a prebiotic. The visible results that I have experienced and observed in my clients include – better deep sleep, better hair, skin and nails – but all these pale in comparison to the benefits you don’t see – the DNA protection, autophagy upregulation, improved cellular communication and much much more.  To try Primeadine for yourself go to Primeadine.com and use promo code BIONAT15 to save 15% off your purchase.   Key Takeaways [00:50] About Daniel Tal.. [02:40] What about this product made Daniel want to create a business with this product?.. [06:52] When did Lumen come to the market?.. [08:55] Who is Lumen appropriate for?.. [13:19] What would be the ideal day for your metabolism according to the Lumen device?... [17:44] Metabolic flexibility, the key to a balanced and healthy body.. [19:50] Customization with the Lumen and how that is done… [26:27] Integration of other devices with the Lumen… [31:45] What should you do to prepare for the Lumen device reading?..  [35:32] Lumen is constantly improving the technology with more data. The more people use it the better the device works. The more you use it the better the device learns you… [40:24] Different devices and the metrics they use to measure metabolism… How Lumen uses carbon dioxide to measure metabolism.. [49:30] Daniel touches on Lumen’s evolution and how Lumen is a company devoted to continually learning and improving their product.    To purchase Lumen you can visit https://www.lumen.me/ and use Promo Code BIONAT to save $25 off your purchase.   Linkage: https://www.facebook.com/groups/lumen.me Instagram: @lumen.me Twitter: @LumenMetabolism     Disclaimer: This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.

In this week’s episode, Nathalie talks to Matt Gallant CEO of BiOptimizers. They go deep into many of the top BiOtpimizers supplements including Magnesium Breakthrough - what makes it stand out in a sea of Magnesium, Masszymes  - how this 17 (!) enzyme formula goes beyond helping you digest your food, P3OM a fresh take on probiotics and the lab in Bosnia that is the key to developing these new and innovative formulas.  And then we talk about Matt’s new venture into Customized Nootropics – Nootopia.  Nootropics – supplements that enhance cognitive function have been a hot topic for years in the Biohacking community but people are often disappointed that what worked wonders for their BFF did nothing for them or worse, turned them into a hot mess.   The fact is that our brain chemistry is unique to each of us so customizing formulas and stacks make all the sense in the world…Nootopia is bringing us the opportunity to access and refine formulas while tapping into experts in the field….as of the time of this writing Nathalie is 3 days into her personalized Nootropic Stack and loving it!     Meet This Week's Guest Matt Gallant is the CEO of BiOptimizers and has a bachelor’s degree in Kinesiology. He’s been a strength and conditioning coach for multiple pro-athletes, a self-defense instructor, and has over 10 years experience formulating supplements.  Matt’s passion and purpose for helping others started when he helped his best friend lose 191 lbs in 18 months.  He watched his friend’s entire life transform as a result.  He went from never having a girlfriend to being married in just a couple of years.     Key Takeaways [01:50] How Matt got to where he is today… [05:05] Masszymes, using it to help make the most of your food, help with digestion and more!.. [8:32] What is the optimal dosing of Masszymes?.. [11:09] BiOptimizers partnership with a research lab and what makes them special.. [12:12] Protein Breakthrough, vegan protein product that doesn’t taste like dirt… [14:21] Using Enzymes to resolve food poisoning… [15:39] Using biofilms in probiotics.. Are biofilms good or bad?.. [18:40] What is Matt’s favorite BiOptimizer product?.. [18:58] Being trapped in fight or flight mode and how it limits your potential… [22:36] Let’s talk magnesium. When is the best time to take it? What is the best type to take? What are cofactors to take with magnesium? Can you take too much?.. [40:30] What are mitochondria? What can we do for mitochondria and what do they have to do with our health?.. What supplements help with mitochondria?.. [52:40] Nootropics and the need to customize them for the individual… [59:09] Matt’s nootropic products… How they work, who is helping him formulate them and more!.. [63:03] Should we be worried about flow agents and the buildup of excipients when it comes to supplements?.. What is BiOptimizers doing to limit our exposure to excipients, gums and flow agents?..   Products can be purchased at https://bioptimizers.com/ or https://nootopia.com/. Use discount code Longevity10.   Linkage Website: https://bioptimizers.com/ Facebook: https://www.facebook.com/BiOptimizers/ Instagram: https://www.instagram.com/bioptimizers/ Youtube: https://www.youtube.com/user/BiOptimizers     Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.    

Biohackers often ask: How long do I need to fast before I am in autophagy?  The answers come back fast and furious and it appears that nobody can agree – 16 hours?  24 hours? 72 hours?  It turns out that the answer is frustratingly: “it depends”…it depends on you, your metabolic flexibility and more…the Biosense device is here to help individuals answer this burning question for themselves. In this week’s episode Nathalie talks to Jim Howard from Readout Health about the Biosense Breath Ketone Monitoring device – a revolutionary method of measuring ketones more precisely without spilling a single drop of blood!  We talk about the ketones, fasting and a new feature on the Biosense App that will help users to tap into their body’s innate mechanisms of repair and renewal – cellular autophagy - by honing in on their individual response.   Meet This Week's Guest Jim Howard is a 27-year medtech executive focused on value creation with novel approaches to patient care. Jim came to Readout as CEO from his EIR position at venture capital firm, BioGenerator, an initial investor in Readout. He is a co-founder and initial CEO of Washington University spinout SentiAR, the first AR platform for interventional procedures, currently in clinical trials. Jim led a team of 50 as VP of Sales in CareFusion’s respiratory business unit through the acquisition by Becton Dickinson in 2016. He is a board director at POC medical device company, MagBiosense, and is an active mentor to new CEO’s in the St. Louis healthcare ecosystem. Jim is passionate about behavioral changes in chronic diseases, putting the healthcare in the hands of patients. He has an MBA from University of Missouri-St.Louis and remains active in collaborations with Washington University researchers.   Episode Sponsor: drinkHRW: This episode is sponsored by drinkHRW.com  manufacturers of the best molecular hydrogen supplements on the market.   For the past 4 years I have been using molecular hydrogen tablets every single day for dozens of reasons including mitigation of oxidative stress, to support my mitochondria and metabolic health, to help me recover from my workouts.  I am such a fan that I have every one of my clients using drinkHRW tablets as a foundation supplement in their stacks whether their goals are healthy aging or increased performance (or both). Check out the amazing products at drinkHRW.com and use promo code Longevity10 to get 10% off your purchase!   Key Takeaways [01:14] About Jim and how he got to run this cool company… [05:13] The ketogenic diet, metabolic flexibility and IM fasting in the reversal of disease… [09:32] What is being measured when using the Biosense?... [12:20] Do the numbers on the Biosense mean the same thing for everyone?.. [15:17] Are continuous glucose monitors accurate?.. [17:52] The effect your microbiome has on your body’s response to sugar… [21:21] Precision fasting, the direct way to get to autophagy… [24:14] Redox potential, the ability of the body to store less BHB over time due to your body becoming more efficient… [27:35] Precision Fast, an actual fasting wheel with precise actual levels of ketosis… [28:59] How long does it take to get into ketosis, autophagy, ect? Is it the same time for everyone?.. [33:33] Tracking metabolic flexibility and ketone production with the Biosense in order to know your individual reactions to foods and exercise so that you can modify behaviors… [36:26] The fast mimicking diet, is it good or bad?.. [45:47] What apps can you sync with Biosense?..   You can purchase the biosense at https://mybiosense.com with promo code Longevity20 to save $20!   Linkage: Website: https://mybiosense.com Instagram: @mybiosense     Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.

In this week’s episode, Nathalie talks with Phil Micans about bioregulator peptides; which ones to take, how long to take for, and more. He also makes the generous offer to send your bioregulator questions to Nathalie and they will do a Q & A in the future answering as many as possible!   Listen up so you know what questions haven’t been asked so far!   Meet This Week's Guest Phil Micans, MS, PharmB - Phil Micans has qualifications (including Masters and Bachelors degrees) from the UK and the USA in Food & Vitamin Technology, Pharmacy and Biochemistry. He has been actively involved in antiaging medicine since the late 1980’s and has contributed to numerous books, magazines, radio and TV shows on various subjects connected to healthy aging. Currently, he is the Editor-in-Chief of the Aging Matters™ Magazine, the Assistant Editor to the Lifespan Medicine Journal (founded by Thierry Hertoghe, M.D.) and Director to the British Longevity Society (founded by Marios Kyriazis, M.D.). He also advises the Stromboli conference on cancer and aging (founded by Walter Pierpaoli, M.D.) and the London Antiageing Conference. In 1991 he was a cofounder of the IAS Group (International Antiaging Systems), an organisation dedicated to the dissemination of preventative and regenerative medicine information and the supply of hard-to-obtain health products.   Bioregulator peptides can be purchased here or at Profound-Health.com save 15% off your first purchase with promo code Longevity15   Episode Sponsor: drinkHRW This episode is sponsored by drinkHRW.com  manufacturers of the best molecular hydrogen supplements on the market.   For the past 4 years I have been using molecular hydrogen tablets every single day for dozens of reasons including mitigation of oxidative stress, to support my mitochondria and metabolic health, to help me recover from my workouts.  I am such a fan that I have every one of my clients using drinkHRW tablets as a foundation supplement in their stacks whether their goals are healthy aging or increased performance (or both). Check out the amazing products at drinkHRW.com and use promo code Longevity10 to get 10% off your purchase!   Key Takeaways [1:30] How Phil got to where he is today… [11:12] Are there peptides in vegetables like there are in meat?.. [13:37] Military secrets and medical breakthroughs… The start of many medical discoveries… [17:23] Peptide bioregulator study in Siberia and the effects on mortality and morbidity… [19:32] The pineal peptide, the little pea sized gland that runs the show… [24:51] Using the Horvath Clock for measuring biological age… Is it the best measurement?.. [29:19] Stress, the biggest factor of aging… [33:48] What bioregulators should you use and in what order?.. [37:09] Using the ovarian peptide for hormone dysregulation and estrogen dominance… [38:30] Why is estrogen dominance so common now days and what can people do about it?..  [45:19] How does the thyroid bioregulator work? Will it help convert T4 to T3?.. [48:05] TRH, is it a bioregulator?.. [59:31] Closing conversations about the less popular peptides such as the lung and bladder bioregulators… [61:02] Silica and the effects on Alzheimer’s…  [68:00] Does the bone marrow bioregulator have the potential to increase stem cells?.. [69:00] How often do bioregulators need to be taken to see changes?.. [71:00] Use of bioregulator peptides in Olympic gymnasts…   Bioregulator peptides can be purchased at https://naturesmarvels.com  save 15% off your first purchase with promo code Longevity15   Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.