Jonathan Downar, a psychiatrist and neuroscience expert who co-authored the textbook 'Brain and Behavior,' joins the discussion on depression's complexity. He delves into how depression can be an evolutionary survival mechanism and the intriguing connections between brain function, emotional resilience, and societal influences. The conversation also covers innovative treatments like transcranial magnetic stimulation (TMS), challenging traditional views on serotonin, and the need for a holistic approach to mental health, much like addressing social issues linked to tuberculosis.

Explore the fascinating nature of perception and how it varies between individuals. Discover why some sounds can be heard differently based on the words we focus on. Delve into the brain's role in creating rich visual experiences, even with eyes closed. Learn about the mysterious cases of fake crosswalk buttons and how our past experiences shape what we see. From 'The Dress' to auditory puzzles, uncover the intricate relationship between expectation and reality.

The podcast dives into how extreme fear influences our perception of time, often making moments feel longer. It features thrilling anecdotes and a bold experiment where volunteers are dropped from a tower to test this phenomenon. Discover how the amygdala shapes our temporal experiences and the intriguing link between stress and memory density. Additionally, learn how to enhance your awareness and make time feel richer by disrupting daily routines, plus a fun exploration of horror in film and its ties to historical anecdotes.

Marilu Henner, an actress renowned for her role in 'Taxi,' shares her experience as one of the few individuals with highly superior autobiographical memory. She discusses the fascinating yet challenging aspects of her extraordinary recall, answering whether it's a blessing or a burden. Henner delves into how remembering every detail from the past shapes her identity. The conversation also touches on memory's role in resilience and personal growth, alongside unique techniques for enhancing one's recollection and mindfulness in everyday life.

In this insightful discussion, cognitive neuroscience professor Joel Pearson explores the intriguing spectrum of mind's eye, mind's ear, and mind's tongue. He dives into aphantasia and hyperphantasia, revealing how these conditions uniquely shape perception and creativity. Pearson shares captivating insights on how artists with aphantasia navigate their craft without mental imagery. He also discusses individual memory strategies, the effects of sensory differences on emotional engagement, and the broader implications for understanding consciousness. A fascinating look at our internal worlds!

Jeff Hawkins, a renowned theoretician and author known for his insights into intelligence, joins the discussion to explore the complexities of brain function. He reveals how the neocortex processes sensory input and dynamically shifts neuron roles. The conversation dives into his revolutionary Thousand Brains Theory, where multiple cortical models collectively create our perception of reality. Hawkins contrasts these biological processes with AI's limitations, shedding light on how our brains uniquely construct a cohesive understanding of the world.

David Eagleman hosts Sara Walker, a theoretical physicist from Arizona State University and author of "Life as No One Knows It." Together, they dive into the perplexing definitions of life and what distinguishes the living from the inanimate. The conversation flirts with ancient philosophies, assembly theory, and the hypothetical discovery of a cell phone on Mars. They explore the complexity of potential extraterrestrial life and the nuances between human intelligence and AI, ultimately challenging listeners to redefine their understanding of existence.

In this discussion, David Eagleman, a renowned neuroscientist specializing in brain science and decision-making, explores the mind's intricate processes when faced with choices. He delves into how conflicting neural networks influence even simple decisions and examines how past experiences and prediction errors shape our actions. Eagleman links cognitive biases to societal events like the 2008 economic crash and advocates for understanding addiction through impulse control rather than legal punishment, emphasizing rehabilitation over retribution.

Explore the fascinating world of decision-making and how our brains juggle options, from choosing a meal to monumental life choices. Discover the role of emotions and logic in our thought processes, and learn about the competition between neural networks when faced with conflicting options. Delve into how technology influences our decision-making, and see how past experiences like brain injuries impact our choices. The podcast intertwines ancient philosophy with modern neuroscience, making for a captivating journey into how we decide.

Explore the fascinating interplay between the brain and humor. Discover why laughter triggers rapid breathing and how other animals express joy. Delve into the secrets behind jokes and the common threads linking comedians, magicians, and mystery novelists. Uncover the evolutionary significance of humor and how it evolves in different cultures. Investigate whether AI can truly be funny, and see how surprise shapes our laughter, creating a unique bonding experience across social groups.