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What's Your Problem?

Latest episodes

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Jun 5, 2025 • 37min

Teaching Robots How to Do Everything

Chelsea Finn, a Stanford professor and co-founder of Physical Intelligence, dives into the fascinating world of teaching robots to perform everyday tasks. She discusses the current limitations of AI in manipulating objects, even for simple chores like laundry folding. Chelsea emphasizes the complexities of training AI models, mentioning a case study on the Pi 0.5 model for household tasks. The conversation also covers the delicate balance between generalist and specialized robots, the ethics of robotics, and the importance of tactile feedback in robot design.
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May 29, 2025 • 38min

Making a Universal Flu Vaccine

Jacob Glanville is a bioengineer and immunologist, and the founder of Centivax, on a mission to create a universal flu vaccine. They dive into the urgency of developing a vaccine that can protect against all flu strains, even future mutations. Glanville discusses innovative research techniques and collaborative efforts to tackle the challenges in vaccine technology. He also highlights the potential impacts on global health and the broader fight against pandemics, sharing insights on fundraising hurdles faced in the biotech industry.
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15 snips
May 22, 2025 • 36min

Teaching Computers to Smell

Alex Wiltschko, co-founder and CEO of Osmo, started out as an AI researcher at Google before combining his childhood passion for perfume with cutting-edge technology. He discusses how Osmo is teaching computers to smell, with potential applications in diagnosing diseases and enhancing security. The conversation also delves into the exciting fusion of AI and fragrance creation, highlighting the innovative perfume line, Generation. Wiltschko shares personal scent experiences and the emotional intricacies linked to our olfactory preferences.
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28 snips
Apr 24, 2025 • 46min

Can a Chatbot Treat Depression?

Nick Jacobson and his team at Dartmouth medical school spent over 100,000 hours trying to build an AI chatbot that can serve as a safe, effective therapist. After a few false starts, they seem to be on to something.Note: This episode contains references to self harm. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.com/plusSee omnystudio.com/listener for privacy information.
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8 snips
Apr 23, 2025 • 47min

Will AI Radically Change the World by 2027?... from Risky Business

This week, Nate and Maria discuss AI 2027, a new report from the AI Futures Project that lays out some pretty doom-y scenarios for our near-term AI future. They talk about how likely humans are to be misled by rogue AI, and whether current conflicts between the US and China will affect the way this all unfolds. Plus, Nate talks about the feedback he gave the AI 2027 writers after reading an early draft of their forecast, and reveals what he sees as the report’s central flaw. Enjoy this episode from Risky Business, another Pushkin podcast. The AI Futures Project’s AI 2027 scenario: https://ai-2027.com/ Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.com/plusSee omnystudio.com/listener for privacy information.
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6 snips
Apr 17, 2025 • 41min

Is the Future of Flight Supersonic?

Blake Scholl, Founder and CEO of Boom Supersonic, dives into the ambitious quest to create a commercial supersonic airplane. He shares insights on the historical journey of air travel speed, tackling the lessons learned from the Concorde and Apollo missions. Blake humorously navigates the challenges of designing such aircraft, discussing engine advancements, funding strategies, and regulatory hurdles. He emphasizes how faster travel can strengthen human connections, along with reflecting on the exhilarating challenges of entrepreneurship and innovation in aviation.
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5 snips
Apr 10, 2025 • 25min

The Secrets of Silk

Fiorenzo Omenetto, a Tufts University Professor and director of Silklab, dives into the intriguing world of silk innovation. He reveals how this ancient material can revolutionize modern medicine, from silk-based microneedle patches for vaccine delivery to breakthroughs in tissue engineering. The conversation also touches on silk's role in food preservation and its transformative applications in technology. Discover how this age-old fiber is reshaping diverse industries while weaving together science, entrepreneurship, and cultural reflections.
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Apr 8, 2025 • 33min

Infiltrating an International Ransomware Gang

Jon DiMaggio, Chief Security Strategist at Analyst One, dives into the dark underbelly of the LockBit ransomware gang he infiltrated using wartime spy tactics. He shares gripping insights on their recruitment strategies and motivations, including shocking attacks like the one on Sick Kids hospital. DiMaggio discusses how international governments countered this menace, using innovative methods to take down their operations. His tale challenges perceptions of cybercriminals, highlighting an unexpected friendship with one, offering a complex view of human connection amidst chaos.
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Apr 3, 2025 • 55min

Preparing for the Future of War

Christopher Kirchhoff, a key figure behind the Defense Innovation Unit, discusses the military's struggle to adapt to rapid technological changes. The conversation explores drone warfare innovations in Ukraine and how they defy traditional military strategies. Kirchhoff emphasizes the need for the U.S. military to update outdated procurement processes and embrace AI, while also reflecting on how autonomous technologies can shift global power dynamics. The urgency for transformation to keep pace with modern threats shares the spotlight with tales of ingenuity in conflict.
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Mar 13, 2025 • 28min

Stopping HIV Without a Vaccine

Jared Baeten is senior vice president in virology at Gilead Sciences. Jared's problem is this: In a world without a vaccine, how do you make a medicine that people will actually take to help prevent HIV?There’s already a daily pill that reduces the risk of getting HIV, but a majority of people who are at high risk are unwilling or unable to take it.So Jared and his colleagues are developing a new drug, lenacapivir, designed to be given as a shot once every six months. Note: The views and opinions expressed in this episode are those of the guest and do not necessarily reflect the views or positions of any entities they represent. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.com/plusSee omnystudio.com/listener for privacy information.

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