DDT Method Podcast

Drew Donaldson
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Nov 24, 2025 • 57min

The Truth About Peptides, EMFs, and Human Optimization

Kris Gethin, a competitive natural bodybuilder turned biohacking expert, shares his journey from mold toxicity to embracing peptides for performance and longevity. He explains why peptides, as signaling molecules, do not violate bodybuilding principles. Listeners learn about his optimized daily routine, which includes ice baths, red light therapy, and fasting techniques. He also highlights effective supplements, the risks of caffeine, and how to shift one’s nervous system toward relaxation. Additionally, Kris discusses strategies to mitigate EMF exposure, making it a must-listen for peak performance enthusiasts.
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Nov 17, 2025 • 1h 1min

This Therapy Supercharges Your Cells (Here’s How)

BloodworkWork with MeJoin my community of advanced biohackersPEMF therapy has been misunderstood as solely a pain management tool, but this episode reveals its profound potential as a performance enhancement technology. Andy Smith, founder of Celler8 and host of the PEMF Podcast, shares how pulsed electromagnetic field therapy works at the cellular level to recharge mitochondria, increase ATP production, and enhance every biohack from red light therapy to cold plunges.After surviving a near-fatal infection at age 25, Andy discovered PEMF's healing power and has spent 13 years educating others on this NASA-backed technology. Dive into the science behind frequency therapy, optimal protocols for athletes and biohackers, proper device selection based on intensity versus frequency, and how PEMF creates the cellular environment needed for supplements and peptides to work effectively. Whether you're an advanced optimizer or managing chronic conditions, this episode demonstrates why PEMF deserves a place in every performance enhancement protocol.Connect with Andy Smith:Instagram - https://www.instagram.com/andysmith_pemf/Podcast - @ThePEMFPodcastCompany - https://www.newmedltd.co.uk
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Nov 10, 2025 • 1h 8min

Complete Human Optimization: Biohacking U’s Blueprint for Cognitive and Physical Enhancement

Work with me!Join my Biohacking Group Real Primal Human - Coaching for Elite MenEpisode Summary:Brandon Eisenhower (@biohackingu) joins Drew to break down the complete optimization playbook for ambitious entrepreneurs and athletes who want peak performance in every domain. This isn't about taking one magic peptide - it's about understanding how to stack cognitive enhancers, physical performance compounds, and recovery protocols into a comprehensive system that actually works. The conversation dives deep into cognitive optimization, comparing long-term brain builders like Dihexa and Cerebrolysin versus short-term stimulant strategies. Brandon explains his controversial take on dopamine system restoration instead of chasing an "Adderall replacement." He shares why working through the serotonin system for anxiety is more sustainable than GABA-focused compounds.Lastly Brandon drops serious knowledge on TRT users missing neurosteroid production from skipping important polypharmacy, explaining the cognitive and sleep benefits most people don't realize they're missing. This episode delivers actionable protocols you can implement immediately while understanding the "why" behind every compound choice.TOP TAKEAWAYS:• Steps to take BEFORE optimizing with compounds • Short-term and long-term nootropic strategies • Dopamine system repair vs Adderall chasing • HCG for cognition • Mitochondrial optimization strategic layeringConnect with Brandon Eisenhower:Instagram: @biohackinguYouTube: @biohackinguWebsite: biohackingu.com
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Nov 4, 2025 • 57min

Building the Perfect Enhancement Protocol for High Performers

Elite Men's Coaching - https://the.realprimalhuman.com/learn-more-hereJoin the Member's Community! Dosing, Protocols and More - https://www.skool.com/ddtmethodEpisode Summary:Chris Duffin sits down with Drew to share decades of practical peptide experience working with elite Bollywood action stars, high-performing executives, and world-class athletes. As the only human to squat and deadlift 1,000 pounds for reps, Chris brings unique insight into optimizing performance at the highest levels. He reveals why fixing dysfunction comes before optimization, explaining his "house building" analogy for understanding how BPC-157, TB-500, GHK-Cu, and KPV work together to create the proper terrain for cellular signaling.The conversation explores Chris's controversial take on popular peptides - why he prefers CJC-1295 over Tesamorelin, his concerns about MK-677, and the IGF-1 protocols that built his legendary strength. Chris breaks down how blood flow restriction training triggers the same angiogenesis and mitochondrial biogenesis signals as peptides, revealing protocols that combine BFR with AMPK-driving compounds for time-efficient muscle building. Drew and Chris compare notes on their current SS-31 and MOTC stacks, discussing optimal timing and why creating cellular responsiveness matters more than adding another compound.Chris shares his foundation supplement stack including fatty-15, TUDCA, ALCAR, and phosphatidylserine - the raw materials cells need before peptides can work properly. From PEMF mats to red light therapy to shockwave, he explains which recovery modalities actually move the needle and how they stack with peptide protocols. Whether you're healing a Bollywood star's staph infection or helping an executive perform at peak capacity while building muscle, this episode delivers battle-tested protocols you won't find anywhere else.CHAPTERS:0:00 - Introduction2:27 - Background & Journey to Human Optimization12:19 - Starting Point: Fixing Dysfunction Before Optimization16:00 - The "Glow Blend" Protocol: BPC, TB500, GHK & KPV18:08 - Understanding Peptide Signaling20:00 - Power Grid Optimization: PEMF, Shockwave & Red Light Therapy23:11 - Training Modalities: BFR, Flywheel & Metabolic Stress25:31 - Blood Flow Restriction: IPC vs Myorep Methods27:04 - The Missing Link in Modern Training30:31 - Peptides for Mass Gainin36:12 - Stacking Modalities for Stem Cell Proliferation36:25 - Growth Hormone Peptide Overview39:27 - Why Chris Avoids MK-677 & Tesamorelin40:00 - Mitochondrial Optimization: SS-31 & MOTS-C Deep Dive43:08 - Drew's Updated Mitochondria Protocol44:08 - Carbon 60: When & Why to Use Antioxidants47:29 - Five Amino 1MQ & TUDKA: NAD Recycling Over Supplementation49:05 - Essential Supplements: Building Cellular Resilience52:02 - The Foundation: Raw Materials, Training & Cellular Health54:05 - Jedi Mastery: Combining Peptides, Training & Biohacking54:35 - Where to Find Chris Duffin & Closing RemarksConnect with Chris Duffin:Instagram: https://www.instagram.com/mad_scientist_duffinYouTube: https://www.youtube.com/user/kabuki07Website: https://www.chrisduffin.com/Free Education Platform: https://www.skool.com/endless-evolution-8560/aboutPaid Education: https://chrisduffin.myshopify.com/pages/community
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Oct 27, 2025 • 1h 8min

LIVE BUILDING My New Protocol with Anthony Castore pt 2

Elite Men's Coaching - https://the.realprimalhuman.com/learn-more-hereJoin the Member's Community! Dosing, Protocols and More - https://www.skool.com/ddtmethodDisclaimer:Since this podcast was recorded some information regarding the initial testing on bioglutide was made public and Anthony has released this statement - https://www.skool.com/castore-built-to-adapt-7414/statement-from-anthony-castore-and-alchemiq-on-the-bioglutide-biomed-situation?p=5245589aEpisode Summary:Drew and Anthony are back with part two, and this one's packed with protocols you can actually use. The big topic? Bioglutide - the newest GLP that's orally available and might be the answer to muscle loss concerns everyone's been talking about. It hits four different pathways including IGF-1, which changes the game for recovery and building muscle while staying lean.Anthony walks through exactly how to transition off retatrutide without losing progress, including the math on half-lives and strategic timing. Drew shares his personal plan for coming off after nearly a year of use, stacking bioglutide with MOTC, SS-31, and growth hormone for a recomp phase. This isn't theory - it's what they're actually doing.The conversation shifts to cellular health foundations that most people skip. Anthony breaks down his daily supplement stack and explains why plasmalogens, phosphatidylcholine, and TUDCA matter more than adding another peptide. They cover senolytic protocols using FOXO-4 to clear out damaged cells, strategic NAD optimization with 5-Amino-1MQ and 1-MNA, and why your membranes need repair before anything else works optimally.Whether you're deep into enhancement protocols or just trying to understand how to support what you're already doing, this episode delivers actionable information you won't find anywhere else.TOP TAKEAWAYS:• Bioglutide as a game-changing quad-agonist• Strategic GLP transitioning - Reta to Bioglutide• FOXO-4 senolytic protocol strategic timing• Plasmalogens the essential cellular membrane building blocks • Build your cellular foundation before advanced protocolsCHAPTERS:0:00 - Introduction 2:13 - Introduction to GLP-1 Agonists & Fat Loss2:58 - Understanding Bioglutide: The Quad Agonist Breakthrough10:40 - IGF-1 Modulation: How Bioglutide Differs from Injectable IGF14:27 - Transitioning Strategies to Bioglutide: Drew's Protocol Plan24:07 - Incorporating MOTS-c for Fuel Switching27:02 - Five Amino 1MQ: NAD Optimization & Fat Cell Reduction30:16 - Senolytic Protocols: FOX04 DRI for Cellular Cleanup38:44 - Introduction to Plasmalogens: The Building Blocks of Cell Membranes54:03 - Essential Supplement Stack: The Foundation for Optimization1:04:52 - Where to Find Anthony Castor & AlchemIQ Labs ProductsConnect with Anthony Castor:Anthony Castor's Community & Resources:Castor Built to Adapt - Free Skool Community - https://www.skool.com/castore-built-to-adapt-7414 Instagram: https://www.instagram.com/anthonycastore/?hl=en
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Oct 20, 2025 • 59min

Minimal Effective Dose: Getting Maximum Results with Less Peptides

DDT Method Experimentation Club - http://bit.ly/3KSdGxnReal Primal Human (RPH) Coaching Program - http://bit.ly/4nl1W3PIn this advanced peptide discussion, Drew Donaldson sits down with human optimization specialist Anthony Castor to decode the controversial SLU-PP-332 dosing debate. While the internet argues between 100 micrograms and 400+ milligrams, Anthony breaks down the science-backed approach to finding your minimal effective dose. This conversation dives deep into mitochondrial function, explaining why overdosing SLU can cause brain fog, insulin resistance, and long-term health issues despite short-term fat loss results.Anthony reveals why most people don't need massive doses of SLU-PP-332, introducing the concept of mitochondrial optimization through strategic stacking with urolithin A. He explains the electron transport chain, mitochondrial fission and fusion, and why supporting your body's natural cleanup processes (mitophagy) is crucial for sustainable results. Drew shares his personal experience titrating from 100 micrograms to 4 milligrams, discovering that 2mg was his sweet spot when supported with proper substrate availability.The episode announces two major launches: the DDT Method exclusive members group for advanced peptide protocols and detailed PED education, plus Real Primal Human (RPH) coaching program featuring elite trainers specializing in human optimization. This is part one of a two-part series delivering actionable protocols for experienced lifters who've plateaued and want to push their physique and performance to the next level through science-backed enhancement strategies.TOP TAKEAWAYS:• Start with minimal effective dosing • Support mitochondrial health with Urolithin A • High doses can backfire • Individual response varies dramatically • Build a stable foundation first CHAPTERS:0:00 - Introduction & Podcast Overview0:53 - Announcements: DDT Method Exclusive Members Group & Real Primal Human Coaching2:29 - Welcome Back: Deep Dive into Peptides with Anthony Castor3:47 - The SLU Dosing Debate: Finding the Right Amount6:04 - Measuring SLU Effectiveness: Objective & Subjective Markers9:08 - Foundation First: Why Starting Dose Matters11:21 - Understanding Dosing Philosophy & Individual Response15:34 - The Problem with Animal Studies & Human Conversion18:01 - Comparing SLU to Known Compounds: The Clenbuterol Analogy20:31 - The Massive Dosage Discrepancy: Micrograms vs Milligrams23:37 - Potential Risks of High-Dose SLU25:09 - Mitochondrial Function & Organ Impact28:04 - Drew's Personal SLU Experience: Testing Different Doses33:01 - Understanding the Brain Fog Effect38:46 - Breaking Down Energy Creation: The Electron Transport Chain Explained47:22 - The Educator's Responsibility in the Modern PED Era48:28 - Introducing Urolithin A: The Missing Piece50:39 - Mitophagy Explained: Fission, Fusion & Cellular Cleanup56:02 - Why Urolithin A + SLU is the Optimal Combination
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Oct 13, 2025 • 1h 3min

Bodybuilding Without Breaking Your Body: Health-First Approach to Extreme Muscle

Pro bodybuilder Dusty Hanshaw joins the DDT Method podcast to share his journey from average genetics to earning his pro card through relentless dedication and smart training. In this comprehensive discussion, Dusty breaks down his experience with DC training and progressive overload protocols, explaining how he maximized his genetic potential by focusing on what he could control rather than lamenting his structural limitations. The conversation covers critical topics including training intensity versus volume, individualized nutrition approaches, and the importance of health monitoring for enhanced athletes.Dusty and host Drew also share remarkably similar near-death experiences involving esophageal ruptures from years of forced feeding, offering a candid look at the often-overlooked risks of extreme bodybuilding practices. The discussion explores how these experiences shaped their current approaches to training, nutrition, and life priorities. Dusty emphasizes the importance of mastering fundamental training and nutrition principles before adding advanced protocols like peptides, and explains why different body parts may require completely different training approaches based on individual response and genetics.TOP TAKEAWAYS:Master the fundamentals first - Progressive overload, consistent nutrition, and proper training intensity matter far more than advanced peptides or supplements. Don't add complexity until you've maximized the basics.Let your body dictate your approach - Pay attention to how your body responds to training and nutrition rather than forcing a one-size-fits-all protocol. Different body parts may require completely different training styles based on your individual response.Health monitoring is non-negotiable - Regular blood work and health screening isn't optional for enhanced athletes. It's okay to lose a competition if your health markers indicate you need to back off, but it's never okay to ignore warning signs.There's no single "right" way to train - The intensity, frequency, and volume debate exists because all three matter, but they can be balanced in different ways. Find what works for your body, recovery capacity, and lifestyle rather than arguing about methods.Hidden dangers exist beyond drugs - Forced feeding and ignoring digestive issues like acid reflux can cause life-threatening complications. Pay attention to seemingly minor symptoms and address them before they become catastrophic.Connect with Dusty Hanshaw:Instagram - @dustyhanshaw08 Email - dusty@dustyhanshaw.comNote: This episode contains important discussions about health risks in bodybuilding. Both host and guest emphasize the critical importance of monitoring health markers and not ignoring warning signs, regardless of competitive goals.
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Oct 6, 2025 • 1h 14min

The Missing Link in Modern Fitness: Core Stability Myths Exposed

David Weck, inventor of the BOSU ball and pioneer of the rope flow movement, joins the DDT Method podcast for an explosive conversation about the fundamental flaws in modern fitness training. Weck shares his journey from Division 3 football player to movement revolutionary, explaining how chronic back pain led him to discover the stability ball and eventually challenge the entire fitness industry's understanding of core stability and human locomotion.In this wide-ranging discussion, Weck dismantles the "core stability equals spinal stiffness" narrative that dominated exercise science in the 2000s, revealing how this flawed approach has created an epidemic of non-contact injuries and limited athletic potential. He introduces the concept of "force transmission" as the true foundation of athletic performance, explaining why balance and fluid movement patterns trump raw strength alone. From his work with world champion long drive golfer Justin James to his revolutionary approach to deadlifting, Weck provides practical insights for advanced athletes looking to break through plateaus while maintaining joint health and movement quality.The conversation covers rope flow origins, the importance of rotational training, the "perfect poise to pounce" single-leg balance position, and Weck's vision for a paradigm shift in human movement understanding. Whether you're a competitive athlete, serious lifter, or movement enthusiast, this episode challenges everything you think you know about training the human body for optimal performance.TOP TAKEAWAYS:Force transmission is king, strength is queen - You can sacrifice some strength but never balance. Without proper force transmission through skeletal alignment, raw strength becomes useless and even dangerous for long-term athletic performance.The "perfect poise to pounce" position - Master single-leg balance by differentiating one side (tying shoulder to hip as tightly as possible) while lengthening the opposite side to optimize polarity, creating instant readiness without fatigue.Rope flow trains systemic beat before syncopation - Unlike jump rope which creates syncopated movement (hands down, feet up), rope flow without jumping teaches rotational rhythm and full-body integration, providing superior carryover to athletic movement.The Weck Method 45 deadlift setup - Feet close together, balanced on fourth and fifth metatarsals with heels hovering, creates pure vertical pull by keeping spine and shin angles congruent while allowing the skeleton to self-adjust for individual imbalances."Sagittalitis" is limiting your potential - Most gym training focuses exclusively on forward-backward and up-down planes while neglecting rotational and lateral movement patterns essential for real-world athletic performance and injury prevention.Connect with David Weck:Website - weckmethod.com Instagram - @thedavidweck X/Twitter - @thedavidweck YouTube - David Weck (coming soon with long-form content)
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Sep 29, 2025 • 1h 5min

Building Your First PED Course: Assessment, Drug Selection & Dose Response Curves

Episode Summary:Performance enhancement specialist Broderick Chavez joins the DDT Method Podcast for an extensive conversation about building effective PED protocols using scientific frameworks rather than cookie-cutter approaches. With nearly 40 years of experience starting as a teenage bodybuilder in the competitive 1980s, progressing through elite powerlifting and strongman, and learning from legends like Dr. Fred Hatfield and Tom Platz, Broderick breaks down his systematic methodology for designing personalized drug courses. This episode covers the critical importance of unified language in enhancement (why "course" beats "cycle"), the steroid family tree classification system (testosterone base, DHT derivatives, and 19-nors), and why growth hormone deserves consideration as foundational infrastructure rather than an advanced addition. Broderick explains how water retention actually builds muscle, why trenbolone's reputation is partially misunderstood through improper context, and the dose-response relationship between body weight and drug selection.The conversation emphasizes assessment-first methodology, examining training history, past drug responses, body composition, and individual goals before selecting compounds. Broderick challenges common industry myths including the overuse of "optimization," the false distinction between "side effects" and "effects," and assumptions about mandatory on-the-fly adjustments versus strategic pre-planning. He provides practical frameworks for understanding why different drug families (DHT for strength with less water, 19-nors for fullness and volume, testosterone derivatives for broad-spectrum effects) serve different physique needs. This episode delivers actionable insights on strategic compound selection, proper dosing escalation, and the often-overlooked importance of building orthopedic infrastructure through growth hormone before accumulating massive muscle mass and training volume.TOP TAKEAWAYS:Language Creates Framework: Using "course" instead of "cycle" fundamentally changes your approach from circular repetition to strategic navigation The Steroid Family Tree: Understanding PED classification - testosterone base, DHT derivatives, 19-norsAssessment Before Protocol: Why effective courses require detailed examination of Athlete’s HistoryGrowth Hormone Infrastructure: How GH develops orthopedic framework and recovery systems, making it more valuable early in enhancement journeys rather than as advanced addition.Effects, Not Side Effects: Every drug produces multiple effects—some desired, some not, depending on context.Connect with Broderick Chavez:Team Evil GSP Member Site - members.teamevilgsp.comInstagram - @teamevilgspFacebook - Team Evil GSP
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Sep 15, 2025 • 1h 10min

The Science of Bridging Bodybuilding Extremes with Optimal Health

Former IFBB Pro Steve Kuclo, who placed 6th at Mr. Olympia and 3rd at Arnold Classic, shares his journey from extreme bodybuilding to functional medicine and longevity optimization. As founder of Upgraded Human Wellness, Steve bridges the gap between performance enhancement and health optimization, revealing advanced protocols for those who want to push limits while maintaining long-term wellness.Steve discusses the critical importance of comprehensive testing, liver health optimization, and smart enhancement strategies that minimize health risks. He reveals how he reversed hypothyroidism naturally, the truth about testosterone dosing, and why most people use far more compounds than necessary. The conversation covers cutting-edge peptide protocols, omega-3 optimization, estrogen management, and the emerging field of longevity medicine that's revolutionizing how athletes approach performance and health.This episode provides actionable insights for both competitive athletes and health-conscious individuals seeking to optimize performance while prioritizing long-term wellness through science-based protocols and comprehensive health monitoring.TOP TAKEAWAYS:• Less is more with enhancement protocols - most people use 2-3x more testosterone and compounds than necessary for optimal results while creating unnecessary health risks• Comprehensive testing including liver enzymes, omega-3 index, and genetic testing reveals long-term damage and optimization opportunities that standard blood panels miss• Liver health is the foundation of all enhancement protocols - NAC and glutathione supplementation can dramatically improve compound metabolism and overall health outcomes• Estrogen management requires precision - both too high and too low estrogen cause serious issues, with natural compounds like DIM often being more effective than harsh AI protocols• Recovery peptides like BPC-157 and TB-500 should be cycled strategically rather than used year-round to maintain effectiveness and avoid potential long-term risksCHAPTERS:00:00 - Introduction: Bridging Bodybuilding and Longevity 03:01 - From Firefighter to IFBB Pro: Steve's Journey 05:54 - The Information Overload Problem in Health 08:26 - Transitioning from Competition to Optimization 11:28 - Testing and Reversing Bodybuilding Damage 14:34 - Natural Thyroid Recovery Protocol 17:27 - Can You Reverse Enhancement Consequences? 21:20 - Smart Enhancement for Young Athletes 25:48 - Testosterone Dosing: Why Less is More 31:08 - Liver Health and Detoxification Protocols 35:05 - Estrogen Management and AI Dangers 39:03 - Hematocrit Management Strategies 42:15 - Omega-3 Optimization and Testing 48:33 - Peptide Protocols for Performance and Recovery 58:53 - Mitochondrial and Longevity Peptides 01:02:14 - Steve's Current Enhancement Protocol 01:06:05 - Working with Upgraded Human WellnessConnect with Steve Kuclo:Instagram - https://www.instagram.com/stevekuclo/Upgraded Human Wellness - https://www.upgradedhuman.comFacebook - https://www.facebook.com/stevekuclo/ TikTok - https://www.tiktok.com/@stevekuclo

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