
JAMAevidence The Rational Clinical Examination
Interviews with authors of Rational Clinical Examination systematic reviews in JAMA about the accuracy of the medical history, physical examination, and laboratory testing for the diagnosis of common medical conditions. JAMAevidence is an evidence-based medicine (EBM) resource created and maintained by JAMA Network to promote the use of EBM to improve patient care.
Latest episodes

Jun 6, 2019 • 10min
Does This Child Have Pneumonia? Interview with Dr Sonal Shah
Dr David Simel discusses Does This Child Have Pneumonia?

Feb 7, 2019 • 14min
Will This Hemodynamically Unstable Patient Respond to a Bolus of Intravenous Fluids? Interview with Dr Peter Bentzer
Dr. Peter Bentzer, an expert in hemodynamic responses in unstable patients, delves into the complexities of fluid management post-resuscitation. He discusses the potential risks associated with aggressive intravenous fluid therapy, highlighting increased mortality rates. Bentzer explains how about 50% of unstable patients may benefit from further fluid administration and explores challenges in assessing fluid responsiveness, particularly in mechanically ventilated cases. He also emphasizes practical bedside techniques like passive leg raising for evaluating fluid needs.

Sep 20, 2018 • 9min
Does This Man With Lower Urinary Tract Symptoms Have Bladder Outlet Obstruction? Interview with Dr Karen D’Silva
Jim Michalski discusses Does This Man With Lower Urinary Tract Symptoms Have Bladder Outlet Obstruction? with author Dr Karen D'Silva

Jun 7, 2018 • 20min
Does This Patient With Liver Disease Have Cirrhosis? Interview with Dr Cynthia Ann Moylan
Dr David Simel discusses Does This Patient With Liver Disease Have Cirrhosis? Interview with Dr Cynthia Ann Moylan

Jun 1, 2017 • 13min
Do Findings on Routine Examination Identify Patients at Risk for Primary Open-Angle Glaucoma? Interview With Dr Delan Jinapriya
Dr David Simel discusses Do Findings on Routine Examination Identify Patients at Risk for Primary Open-Angle Glaucoma? with Dr Delan Jinapriya.

Mar 2, 2017 • 33min
Does This Patient Have Infectious Mononucleosis? Interview With Dr Christina Minami
Dr Ed Livingston discusses Does This Patient Have Infectious Mononucleosis? with Dr Christina Minami.

Feb 7, 2017 • 8min
Does This Women Have an Ectopic Pregnancy? Interview With Dr John R. Crochet
Dr David L. Simel discusses Does This Woman Have an Ectopic Pregnancy with Dr John R. Crochet.

Nov 3, 2016 • 25min
Will Neuroimaging Reveal a Severe Intracranial Injury in This Adult With Minor Head Trauma? Interview With Dr Joshua S. Easter
Dr Ed Livingston discusses Will Neuroimaging Reveal a Severe Intracranial Injury in This Adult With Minor Head Trauma? with Joshua S. Easter, MD, MSc

Oct 6, 2016 • 8min
Does This Adult Patient Have Blunt Intra-abdominal Injury? Interview With Dr Daniel K. Nishijima
Dr David Simel discusses Does This Adult Patient Have Blunt Intra-abdominal Injury? with Daniel K. Nishijima, MD, MAS.

Sep 1, 2016 • 12min
Does This Adult Patient With Suspected Bacteremia Require Blood Cultures? Interview With Dr Bryan Coburn
Dr. Bryan Coburn, a medical expert in bacteremia and blood cultures, joins the discussion to dissect when blood cultures are essential for hospitalized patients suspected of bacteremia. He emphasizes that only about 15% of blood cultures provide true positives and highlights clinical signs, such as shaking chills, as crucial indicators. The conversation also uncovers the risks of routine testing, false positives, and the importance of rapid diagnostic advancements, advocating for a thoughtful approach to testing based on clinical context.
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