Unbiased Science

On this week's episode we discuss mutations, specifically in the context of SARS-CoV-2. We set the stage by describing what a mutation is and how this random process occurs in all organisms. We discuss the emergence of SARS-CoV-2 and a primer on zoonotic diseases before focusing on mutation rates of SARS-CoV-2, and comparison to another RNA virus, influenza virus. We talk about the key mutations of the variants of concern B.1.1.7, B.1.351, and P.1 and the spike antigen of the virus, and why these mutations have become more prevalent. We wrap up with a discussion on the implications of vaccine efficacy in light of these new variants, and underscore the need for rapid vaccination globally.PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this week's episode of the podcast, we discuss protections in place for human research subjects. To start the conversation, we discuss some infamous examples of past injustices conducted in the name of "research" and the regulations they prompted as a result. We highlight four cases: the Holocaust experiments, the Tuskegee Syphilis Study, the work of James Marion Sims, and the case of Henrietta Lacks. We spend some time detailing historical documents and regulations that were developed to protect human subjects that came out of these horrific historical blunders and atrocities. Next, we discuss in detail what "informed consent" means, the rigorous regulatory process for any research involving humans, and the modern-day Institutional Review Board (IRB). We recognize that there continues to exist distrust of science and the medical establishment, particularly among populations of color, and our hope is that this episode sets the stage for future conversations that are needed to address this complex issue.PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

This week we answer a commonly encountered question: "why were we able to develop a COVID-19 vaccine in less than a year, but don't have a vaccine for HIV?"We begin with the population health statistics of HIV globally to set the stage. We then do a primer on classification of viruses to underscore the fact that not all viruses are the same. We focus on SARS-CoV-2 and HIV specifically, and do a brief compare and contrast between the two viruses and virus families.We focus specifically on the challenges of vaccine development in the context of HIV: complexity of the virus itself, immune response to the virus, and disease pathology. We reiterate that the foundational research for the SARS-CoV-2 vaccine has actually been ongoing since 2002, and wrap up with our hope that someday we will be able to successfully develop an effective HIV vaccine.PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

This week on the pod we discuss something we hear about all the time: the alkaline diet and alkaline water. Promised to prevent cancer and other ailments, this diet claims to be able to alter the pH of your body. First we set the stage with a primer on what the pH scale is and how it relates to acidity or alkalinity of substances. We discuss the concept of homeostasis in the human body and how our organ and buffer systems ensure the pH of our blood and other compartments are tightly regulated. We continue with a summary on the history of the alkaline diet origins, and wrap up with a review of the health claims affiliated with the alkaline diet, and whether the data supports or refutes those claims.PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode, we discuss whether or not detox diets or juice cleanses have any evidence behind their claims. We start off with a summary of what is considered a detox or cleanse, and compare it with what is actually classified as medical detoxification. We discuss the differences between the appearance of efficacy and actual efficacy of these diets, as well as the marketing tactics of this massive industry and misleading claims made about these products. We discuss some popular "detox" diets such as the master cleanse, and the risks involved with no- or low-calorie diets that lack essential nutrients. We move the conversation to our bodies' incredible organ systems that actually keep us healthy-- specifically our kidneys, liver, and excretory system. We spend some time talking about the very popular celery juice cleanse, its origins, nutritional value, and potential risks. Finally, we try to arm listeners with tools to spot fad and pseudoscience diets and differentiate them from nutritionally and scientifically sound ones. We reiterate that detox diets and juice cleanses should not be taken lightly, and you should always consult with a medical professional before deciding to alter your diet significantly.PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

We are back at it again with part 2, discussing what the term organic means in the context of farming, produce, and consumer products. This week, after a recap, we continue our discussion, first focusing on environmental impact, and elaborate on a few fallacies that circulate with regard to organic products. Following that, we discuss the implications of hormones and antibiotics in rearing livestock in conventional farming, and debunk a few misconceptions with some data. We then discuss animal welfare on organic farms, a topic of great concern to many. Finally, we wrap up with a discussion of “the dirty dozen” a list claiming to be the most pesticide-laden produce products each year, and why the data doesn’t support that claim.PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this week's episode, we take a little break from COVID-19 to talk about organics! First, we refresh everyone’s memory from our GMO episodes, to clarify the difference between organic farming (a cultivation method) and GMO technology (a breeding method). We discuss what the organic label actually means and doesn't mean, and debunk the myth that organic products are pesticide-free. We talk about different examples of organic pesticides and how, at certain doses, they can actually be quite toxic (remember, the dose makes the poison)! We also discuss the differences between synthetic and organic pesticides, and some key factors to consider amongst the two. We briefly discuss the higher cost of organic products and whether it's justified. Finally, we spend some time discussing the evidence (or lack thereof) that organic foods have a higher nutritional value than their traditional counterparts, with a promise to continue this discussion on our next episode!PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

We are back again with the fourth (and final) episode in our series on debunking vaccine myths. In this week's episode, we focus specifically on the two COVID-19 vaccines (from Pfizer-BioNTech and Moderna). We kick things off with a discussion of the vaccine development timeline and address concerns that the vaccines were rushed; we break down the typical clinical trial timeline and how things are affected by the urgency of a pandemic. Next, we debunk the misconception that RNA vaccines are brand new by describing three decades worth of research that has gotten us to this point. We move on to squash the idea that animal trials were skipped (spoiler alert: they were not)! Next, we talk about why we shouldn't just get one dose of the vaccine. We discuss allergic reactions to the vaccine and that they are extremely rare. We also make a distinction between people with allergies versus those who are immunocompromised/immunosuppressed or have autoimmune disorders. And finally, we conclude by discussing why people who have previously had COVID-19 should still get the vaccine since vaccine-induced immunity may actually be more robust and last longer than natural immunity.PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, various vaccine myths are tackled, particularly misconceptions about adverse events and the safety of COVID-19 vaccines. The role of the Vaccine Adverse Event Reporting System (VAERS) is examined, discussing its usefulness and limitations. Discussions clarify that correlation does not equal causation. Myths around vaccines affecting DNA or causing infertility are debunked with scientific insights. Emphasis is placed on understanding the critical benefits of vaccination compared to rare risks.

Vaccine hesitancy remains a critical global health threat. The hosts debunk myths like vaccines causing autism and the belief that natural immunity outperforms vaccine-acquired immunity. They underscore the significance of herd immunity and how vaccination works in community health. There's a compelling discussion on the role of hygiene versus vaccines in disease reduction, alongside the dangers posed by dormant viruses. The importance of sticking to recommended immunization schedules is emphasized, reinforcing that vaccination is a communal responsibility.