Osterholm Update

<p>In "H5N1 Uncertainty," Dr. Osterholm and Chris Dall discuss the latest national COVID trends, a recent study on Paxlovid, and H5N1 avian flu virus infection in cattle. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews two members of the podcast team.</p> <p>Please fill out our <a href="https://redcap.ahc.umn.edu/redcap/surveys/?s=DKAXDYKTDXCN4HLT">Listener Feedback Survey</a>!</p> <p><a href="https://www.cidrap.umn.edu/covid-19/swedish-study-suggests-link-between-long-covid-and-severity-illness">Swedish study suggests link between long COVID and severity of illness</a>&nbsp;(Stephanie Soucheray,&nbsp;<em>CIDRAP News</em>)</p> <p><a href="https://www.cidrap.umn.edu/covid-19/study-long-covid-affects-8-those-covid-19-more-common-women">Study: long COVID affects 8% of those with COVID-19, is more common in women</a> (Stephanie Soucheray,&nbsp;<em>CIDRAP News</em>)</p> <p><a href="https://www.cidrap.umn.edu/covid-19/new-neurologic-issues-less-likely-after-severe-covid-flu-research-suggests">New neurologic issues less likely after severe COVID than flu, research suggests</a> (Mary Van Beusekom,&nbsp;<em>CIDRAP News</em>)</p> <p><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2309003">Nirmatrelvir for vaccinated or unvaccinated adult outpatients with COVID-19</a> (Hammond et al.,&nbsp;<em>New England Journal of Medicine</em>)</p> <p><a href="https://www.nejm.org/doi/full/10.1056/NEJMe2402224">Treating acute COVID-19 — final chapters still unwritten</a> (Gandhi &amp; Hirsch,&nbsp;<em>New England Journal of Medicine</em>)</p> <p><a href="https://www.cidrap.umn.edu/osterholm-update">More episodes</a></p> <p><a href="cidrap.umn.edu/support">Support this podcast</a></p>

<p>In "Good News in a COVID-Indifferent World," Dr. Osterholm and Chris Dall discuss the national and international COVID trends, the latest research on long COVID, and antibiotic-resistant <em>Shigella</em>. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews members of the podcast team.&nbsp;</p> <ul> <a href="https://doi.org/10.1038/s41590-024-01754-8">Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19</a> (Hanson et al.,&nbsp;<em>Nature Immunology</em>)<br> <a href="https://www.pewresearch.org/science/2024/03/07/how-americans-view-the-coronavirus-covid-19-vaccines-amid-declining-levels-of-concern/">How Americans view the coronavirus, COVID-19 vaccines amid declining levels of concern</a> (Tyson &amp; Pasquini,&nbsp;<em>Pew Research Center</em>)<br> <a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/spike-extensively-drug-resistant-shigella-cases-reported-uk-europe">Spike in extensively drug-resistant Shigella cases reported in UK, Europe</a> (Dall,&nbsp;<em>CIDRAP News</em>)<br> <a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/cdc-warns-increase-extensively-drug-resistant-shigellosis">CDC warns of increase in extensively drug-resistant shigellosis</a> (Dall,&nbsp;<em>CIDRAP News</em>)<br> <a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/superbugs-you">Superbugs &amp; You podcast</a> — new episode&nbsp;coming 3/26!<br> <a href="https://www.theguardian.com/society/2020/may/26/last-iron-lung-paul-alexander-polio-coronavirus">The man in the iron lung</a> (McRobbie, <em>The Guardian</em>)<br> <a href="https://www.cidrap.umn.edu/osterholm-update">More episodes</a><br> <a href="cidrap.umn.edu/support">Support this podcast</a> </ul>

Dr. Osterholm discusses new CDC COVID isolation guidelines, a measles outbreak in Florida, avian influenza news, and updates on influenza and RSV cases in the U.S. He stresses the importance of accurate information during the pandemic and shares insights into public health history.

<p>In this episode, Dr. Osterholm and Chris Dall discuss COVID isolation guidelines, the BA.2.87.1 variant, and the importance of measles and other rare public health threats.&nbsp;</p>

<p>In "A Family Discussion," Dr. Osterholm and Chris Dall discuss the latest SARS-CoV-2 variant, consider the current and future challenges accessing Paxlovid, and explore new long COVID research. Dr. Osterholm also revisits last episode's discussion on changing public health guidelines and celebrates some canine heroes in the "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="https://www.pnas.org/doi/10.1073/pnas.2300644120">Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes</a> (Yue Zhang,&nbsp;<em>PNAS</em>)<br> <a href="https://www.startribune.com/minnesota-hospitals-say-65000-days-of-care-were-avoidable-if-patients-had-somewhere-to-go/600340025/">Minnesota hospitals say 65,000 days of care were avoidable if patients had somewhere to go</a>&nbsp;(Jeremy Olson,&nbsp;<em>Star Tribune</em>)<br> <a href="https://www.health.state.mn.us/diseases/coronavirus/paxrx.pdf">Have a Paxlovid Prescription? Low Cost Options Available</a> (Minnesota Department of Health)<br> <a href="https://treatments.hhs.gov/">Find COVID-19 Medications</a> (Administration for Strategic Preparedness and Response, HHS)<br> <a href="https://www.washingtonpost.com/lifestyle/2024/01/31/shelter-dog-rescue-homeless-fayetteville/">Homeless man leaves puppies at N.C. shelter with heart-tugging note</a> (Cathy Free,&nbsp;<em>Washington Post</em>) </ul>

<p>In "A Period of Transition," Dr. Osterholm and Chris Dall discuss the latest COVID-19 trends in the U.S. and around the world, a recent study on long COVID, and the rise of measles cases in the United States. Dr. Osterholm also provides an update on influenza and RSV cases in the U.S. and shares the latest "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="https://www.science.org/doi/10.1126/science.adg7942">Persistent complement dysregulation with signs of thromboinflammation in active long COVID</a> (Cervia-Hasler et al.,&nbsp;<em>Science</em>)<br> <a href="https://erictopol.substack.com/p/lighting-up-long-covid">Lighting up long COVID</a> (Eric Topol,&nbsp;<em>Ground Truths</em>)<br> <a href="http://tinyurl.com/LCEditorial">Follow up, funding critical on long COVID</a> (Jill Burcum,&nbsp;<em>Star Tribune</em>)<br> <a href="https://www.cidrap.umn.edu/covid-19/does-paxlovid-prevent-long-covid-maybe-experts-suggest">Does Paxlovid prevent long COVID? Maybe, experts suggest</a> (Stephanie Soucheray,&nbsp;<em>CIDRAP News</em>) </ul>

<p>In "No Time to Quit," Dr. Osterholm and Chris Dall discuss the JN.1 variant, Paxlovid uptake, and COVID-19 vaccine disinformation. Dr. Osterholm also provides an update on influenza and RSV transmission and shares the latest "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="https://www.latimes.com/opinion/story/2024-01-04/covid-2024-flu-virus-vaccine">Opinion: The U.S. is facing the biggest COVID wave since Omicron. Why are we still playing make-believe?</a> (Eric Topol, <em>LA Times</em>)<br> <a href="https://www.nytimes.com/2024/01/04/health/paxlovid-covid-treatment.html">Paxlovid Cuts Covid Death Risk. But Those Who Need It Are Not Taking It</a> (Christina Jewett,&nbsp;<em>New York Times</em>)<br> <a href="https://www.cidrap.umn.edu/covid-19/commentary-what-can-masks-do-part-1-science-behind-covid-19-protection">COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection</a> (Brosseau et al.,&nbsp;<em>CIDRAP</em>) </ul>

<p>In this episode, Dr. Osterholm and Chris Dall discuss the JN.1 variant, the rising levels of SARS-CoV-2 in wastewater, and the low uptake of the COVID-19, RSV, and influenza vaccines. Dr. Osterholm also shares his thoughts on hospital capacity issues in the U.S. and shares the latest "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="cidrap.umn.edu/support">Support this podcast</a> </ul>

<p>In "A Seasonless Virus," Dr. Osterholm and Chris Dall discuss the latest COVID-19 trends in the U.S. and around the world, provide an update on influenza and RSV activity, and review two recent studies on long COVID. Dr. Osterholm also answers a listener question on fomite transmission of SARS-CoV-2 and celebrates a recent event in public health history.&nbsp;</p> <ul> <a href="https://www.cidrap.umn.edu/covid-19/report-underscores-financial-pressure-long-covid-families">Report underscores financial pressure of long COVID on families</a> (CIDRAP News)<br> <a href="https://www.cidrap.umn.edu/covid-19/5-covid-infected-us-veterans-still-had-symptoms-1-year-later">5% of COVID-infected US veterans still had symptoms up to 1 year later</a>&nbsp;(CIDRAP News) <p><a href="https://www.nature.com/articles/s41467-021-25156-8">SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters</a> (<em>Nature Communications</em>, Port et al)</p> <p><a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/high-prevalence-multidrug-resistant-infections-reported-ukraine-hospitals">High prevalence of multidrug-resistant infections reported in Ukraine hospitals</a> (CIDRAP News)</p> </ul> <p>As we near the end of the year, please consider CIDRAP in your charitable giving. To contribute to this podcast and everything we do here at CIDRAP,&nbsp;visit&nbsp;<a href="https://www.cidrap.umn.edu/support">CIDRAP.umn.edu/support</a>.</p>

<p>In "The Hospital Capacity Crisis," Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and around the world, the reclassification of the BA.2.86 variant as a variant of interest, and the surge in pediatric pneumonia hospitalizations in China. Dr. Osterholm also provides an update on influenza and RSV in the U.S. and shares a moment of joy from one of our listeners.&nbsp;</p> <ul> <a href="https://www.cdc.gov/respiratory-viruses/whats-new/covid-19-variant-update-2023-11-27.html#print">Update on SARS-CoV-2 Variant BA.2.86 Being Tracked by CDC</a><br> <a href="https://www.covid.gov/tests">Free at-home COVID tests</a><br> <a href="https://www.nytimes.com/2023/11/13/upshot/long-covid-disability.html">Can’t Think, Can’t Remember: More Americans Say They’re in a Cognitive Fog</a> (Francesca Paris,&nbsp;<em>New York Times</em>) </ul>