
Literally! With Rob Lowe
This is literally a podcast where people I love, admire, and know well will be in a safe space to really let their hair down (assuming they have any). I will cover the thoughtful to the extremely random. So join me and my guests from the world of movies, TV, sports, music, and culture for fun, wide-ranging, free-wheeling conversations.
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Latest episodes

Jun 26, 2025 • 49min
Larry Charles: Jake and the Fatman
Rob and Larry are comedy nerds. Larry Charles, the director of “Borat” and “Curb Your Enthusiasm,” joins Rob Lowe to discuss working with Bob Dylan and Larry David, the experience of shooting “Borat,” their mutual friend Arsenio Hall, his new memoir, and much more.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Jun 19, 2025 • 48min
Sir Jonathan Pryce: Playing Animal
Rob is Sir Jonathan Pryce’s biggest fan! The legendary actor joins Rob Lowe to discuss how the late Pope Francis inspired his performance in “Game of Thrones,” acting lessons from Al Pacino, his favorite theaters to perform in, how the loss of his father inspired him to take on “Hamlet,” the new season of “Slow Horses,” and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Jun 12, 2025 • 45min
Ralph Macchio: Johnny & Sodapop
Ralph and Rob are “Outsiders” for life. Ralph Macchio and Rob Lowe reunite in the studio to discuss “Karate Kid: Legends” (in theaters now), their memories from shooting “The Outsiders,” Ralph's star on the Hollywood Walk of Fame, the global legacy of “Karate Kid,” and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Jun 5, 2025 • 58min
Rhett & Link: Uni Milkshakes
Rhett McLaughlin and Link Neal, the dynamic duo behind Good Mythical Morning, dive into their hilarious journey in digital media. They share stories about their rise from local commercials to YouTube fame, highlighting the joy of culinary adventures and their love for cherry pie. Discover how they've adapted to new content strategies while maintaining their originality amidst fame. From uni milkshakes to heartfelt memories of North Carolina, their banter is both entertaining and nostalgic, showcasing the fun side of their creative process.

May 29, 2025 • 49min
Patrick Schwarzenegger: Mr. Zeitgeist
Rob and Patrick are practically family! The “White Lotus” star joins Rob Lowe to discuss his father Arnold's softening with age, his experiences at the Met Gala and the Cannes Film Festival, bonding with his family on "White Lotus," and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 22, 2025 • 50min
Ike Barinholtz: Wahlberg Adjacent
Rob and Ike are the biggest Kate Hudson fans! Actor Ike Barinholtz (The Mindy Project, The Studio, Running Point) joins Rob Lowe to talk about their mutual friends Kate Hudson and Amy Poehler, the time Ike ate the coconut cake Tom Cruise gifted to Mindy Kaling, Rob’s look-a-like in the Lakers organization, doing improv in Amsterdam with Seth Meyers, and much more.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 15, 2025 • 50min
Penn Jillette: Dice Stacking
Penn and Rob wish they were invited to "We Are the World!" Magician, television presenter, and author Penn Jillette (of Penn & Teller) joins Rob Lowe to discuss his surprising favorite magic trick, the genius of Bob Dylan, 50 years of “Penn & Teller,” and his new novel.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 8, 2025 • 42min
Kelsey Grammer: A Brother Remembers
Kelsey Grammer returns to "Literally” for a moving episode. The "Frasier" and "Cheers" star joins Rob Lowe to discuss his deeply cathartic new book, "Karen: A Brother Remembers," the tragic loss of his sister, his return to the world of "X-Men" and Marvel, why he still finds joy in acting, and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 1, 2025 • 49min
Chelsea Handler: International Boyfriend
It’s always outrageous when Rob and Chelsea Handler get together! Comedian, writer, and host of the “Dear Chelsea” podcast Chelsea Handler joins Rob Lowe to discuss their perspectives on aging, the ski season, what she’s looking for in an “international boyfriend,” Rob’s early days of sobriety, and much more.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Apr 24, 2025 • 1h 10min
Filmmaker Gavin O’Connor: Theatre Rat
Gavin O'Connor, a notable filmmaker behind hits like Miracle and The Accountant, joins the conversation. He shares fascinating stories about casting Kurt Russell and highlights his collaborative journey with Ben Affleck. O'Connor reflects on his theater roots, the art of storytelling, and the significant performances that influenced him. He also discusses his latest project, The Accountant 2, and the challenges of navigating creativity in today's film industry. Prepare for an engaging dialogue full of cinematic insights and personal anecdotes!