
Literally! With Rob Lowe
This is literally a podcast where people I love, admire, and know well will be in a safe space to really let their hair down (assuming they have any). I will cover the thoughtful to the extremely random. So join me and my guests from the world of movies, TV, sports, music, and culture for fun, wide-ranging, free-wheeling conversations.
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Latest episodes

Jun 5, 2025 • 58min
Rhett & Link: Uni Milkshakes
Rhett McLaughlin and Link Neal, the dynamic duo behind Good Mythical Morning, dive into their hilarious journey in digital media. They share stories about their rise from local commercials to YouTube fame, highlighting the joy of culinary adventures and their love for cherry pie. Discover how they've adapted to new content strategies while maintaining their originality amidst fame. From uni milkshakes to heartfelt memories of North Carolina, their banter is both entertaining and nostalgic, showcasing the fun side of their creative process.

May 29, 2025 • 49min
Patrick Schwarzenegger: Mr. Zeitgeist
Rob and Patrick are practically family! The “White Lotus” star joins Rob Lowe to discuss his father Arnold's softening with age, his experiences at the Met Gala and the Cannes Film Festival, bonding with his family on "White Lotus," and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 22, 2025 • 50min
Ike Barinholtz: Wahlberg Adjacent
Rob and Ike are the biggest Kate Hudson fans! Actor Ike Barinholtz (The Mindy Project, The Studio, Running Point) joins Rob Lowe to talk about their mutual friends Kate Hudson and Amy Poehler, the time Ike ate the coconut cake Tom Cruise gifted to Mindy Kaling, Rob’s look-a-like in the Lakers organization, doing improv in Amsterdam with Seth Meyers, and much more.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 15, 2025 • 50min
Penn Jillette: Dice Stacking
Penn and Rob wish they were invited to "We Are the World!" Magician, television presenter, and author Penn Jillette (of Penn & Teller) joins Rob Lowe to discuss his surprising favorite magic trick, the genius of Bob Dylan, 50 years of “Penn & Teller,” and his new novel.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 8, 2025 • 42min
Kelsey Grammer: A Brother Remembers
Kelsey Grammer returns to "Literally” for a moving episode. The "Frasier" and "Cheers" star joins Rob Lowe to discuss his deeply cathartic new book, "Karen: A Brother Remembers," the tragic loss of his sister, his return to the world of "X-Men" and Marvel, why he still finds joy in acting, and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

May 1, 2025 • 49min
Chelsea Handler: International Boyfriend
It’s always outrageous when Rob and Chelsea Handler get together! Comedian, writer, and host of the “Dear Chelsea” podcast Chelsea Handler joins Rob Lowe to discuss their perspectives on aging, the ski season, what she’s looking for in an “international boyfriend,” Rob’s early days of sobriety, and much more.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Apr 24, 2025 • 1h 10min
Filmmaker Gavin O’Connor: Theatre Rat
Gavin O'Connor, a notable filmmaker behind hits like Miracle and The Accountant, joins the conversation. He shares fascinating stories about casting Kurt Russell and highlights his collaborative journey with Ben Affleck. O'Connor reflects on his theater roots, the art of storytelling, and the significant performances that influenced him. He also discusses his latest project, The Accountant 2, and the challenges of navigating creativity in today's film industry. Prepare for an engaging dialogue full of cinematic insights and personal anecdotes!

Apr 17, 2025 • 56min
Jason Isaacs: TV Dad
Jason Isaacs and Rob Lowe are fighting over Patrick Schwarzenegger! The “White Lotus" and "Harry Potter" actor joins Rob Lowe to discuss his brushes with injury on the set of “White Lotus,” the Duke University controversy, his belief in ghosts, TV kids vs. your real-life kids, and much more.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Apr 10, 2025 • 54min
Fortune Feimster: Oktoberfest with Arnold
Fortune wants to enjoy some cigars with Rob and Arnold! Comedian, actress, and "Handsome" co-host Fortune Feimster joins Rob Lowe to discuss their mutual friend Arnold Schwarzenegger, the North Carolina accents in “White Lotus,” her hilarious (and disastrous) marriage proposal, why she has no interest in mixing comedy and politics, and much more.Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Apr 3, 2025 • 51min
Titus Welliver: Save the Robots
Harry Bosch himself, actor Titus Welliver (star of the hit shows “Bosch” and “Bosch: Legacy”), joins Rob Lowe to discuss the glory days of New York City nightlife, singing with John Lennon as a kid, the time Titus almost left acting, watching your children find their passions, and how a bit of luck led him to the iconic role of Harry Bosch. Plus, Rob tries to convince Titus to write a memoir!Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!