
Harrison's PodClass: Internal Medicine Cases and Board Prep
Produced by McGraw Hill, Harrison's Podclass delivers illuminating and engaging discussions led by Drs. Cathy Handy Marshall and Charlie Wiener of The John Hopkins School of Medicine on key topics in medicine, featuring board-style case vignettes from Harrison's Review Questions and chapters from the acclaimed Harrison's Principles of Internal Medicine – available on AccessMedicine from McGraw Hill.
Latest episodes

Feb 27, 2025 • 6min
Ep 135: Elderly Couple Considering Home Renovations
In this episode, we discuss the impact of ambient and household air pollutants, which may significantly affect respiratory and cardiac health.See more on this topic on AccessMedicine.Harrison's Principles of Internal Medicine, 22nd Edition

Feb 20, 2025 • 8min
Ep 134: A 72-Year-Old Man with New-Onset Seizures
In this episode, we discuss a 72-year-old man with new-onset seizures, exploring potential etiologies and initial treatment.See more on this topic on AccessMedicine.Harrison's Principles of Internal Medicine, 22nd Edition

14 snips
Feb 13, 2025 • 8min
Ep 133: A 45-Year-Old with Difficulty Climbing Stairs
A young man struggles with shortness of breath, prompting an intriguing look into familial links to lung conditions. The case reveals a restrictive pulmonary defect while maintaining normal cardiac function, raising diagnostic challenges. The conversation shifts to the fascinating connection between interstitial lung disease and telomere length, highlighting its significance in prognosis. Finally, the hosts dive into telomere diseases, discussing their impact on organ function and the complexities surrounding lung fibrosis.

Feb 6, 2025 • 9min
Ep 132: A 72-Year-Old with Fatigue and Dyspnea on Exertion
A 72-year-old woman struggles with fatigue and respiratory distress following a blood transfusion. The discussion highlights the significance of cancer screening and regular medical check-ups for older adults. It dives deep into Transfusion-Related Acute Lung Injury (TRALI), examining its causes and management. The podcast also covers complications from blood transfusions, detailing citrate toxicity and the risks of massive transfusions. Listeners gain insights into the importance of pre-transfusion testing and supportive care in managing these complications.

Jan 30, 2025 • 7min
Ep 131: A 55-Year-Old with Differing Causes of Shortness of Breath
Discover how point-of-care ultrasound is revolutionizing bedside examinations. Learn about its evolution from bulky machines to portable devices, making patient assessments more efficient. The podcast dives into diagnosing shortness of breath using POCUS, showcasing its strengths and limitations. Explore how POCUS enhances diagnostic accuracy for respiratory conditions like pneumothorax and pleural effusions, ultimately improving patient care. This blend of technology and medicine illustrates a significant leap in clinical practice.

Jan 23, 2025 • 7min
Ep 130: A 27-Year-Old with Penicillin Allergy
A young woman with a history of penicillin allergy and an indication for penicillin treatment. The discussion focuses on mechanisms of penicillin allergy and the utility of desensitization.See more on this topic on AccessMedicineHarrison's Principles of Internal Medicine, 22nd Edition

Jan 16, 2025 • 9min
Ep 129: A 68-Year-Old with Lower Abdominal Pain
This episode talks about acute kidney injury, its complications, potential etiologies, and therapy.See more on this topic on AccessMedicineHarrison's Principles of Internal Medicine, 22nd Edition

Jan 9, 2025 • 5min
Ep 128: A 72-Year-Old with Elevated White Blood Cell Count
A fascinating case of a 72-year-old man reveals elevated white blood cell counts tied to his smoking habit. Symptoms like a new cough and weight loss raise critical questions. The discussion delves into granulocytosis and its surprising links to malignancies, especially lung cancer. Misconceptions are clarified, highlighting the importance of monitoring granulocytosis as a potential cancer indicator, but with a reassuring note that it often resolves with treatment.

Jan 2, 2025 • 7min
Ep 127: A 65-Year-Old Male with a Spot on His Foot
This episode presents a 65-year-old man with a new pigmented lesion on the sole of his foot. The discussion focuses on the differential diagnosis.See more on this topic on AccessMedicine.Harrison's Principles of Internal Medicine, 22nd Edition

Dec 26, 2024 • 8min
Ep 126: A 60-Year-Old with Fever, Purulent Sputum, and Chest Pain
This episode presents a 60-year-old man with acute respiratory symptoms and a cavitary lesion on chest CT. The discussion focuses on the likely etiology and appropriate therapy.Harrison's Principles of Internal Medicine, 22nd Edition