
Harrison's PodClass: Internal Medicine Cases and Board Prep
Produced by McGraw Hill, Harrison's Podclass delivers illuminating and engaging discussions led by Drs. Cathy Handy Marshall and Charlie Wiener of The John Hopkins School of Medicine on key topics in medicine, featuring board-style case vignettes from Harrison's Review Questions and chapters from the acclaimed Harrison's Principles of Internal Medicine – available on AccessMedicine from McGraw Hill.
Latest episodes

15 snips
May 8, 2025 • 12min
Ep 145: A 45-Year-Old Snorer
A 45-year-old man's struggle with worsening snoring highlights the serious world of sleep apnea. The podcast dives into the differences between obstructive and central sleep apnea, exploring diagnostic criteria and treatment options. Key discussions include the importance of polysomnography for diagnosis and the interplay between obesity and sleep apnea. The impact of sleep apnea on cardiovascular health is emphasized, along with lifestyle changes and the effectiveness of CPAP therapy in improving quality of life.

7 snips
May 1, 2025 • 8min
Ep 144: A 35-Year-Old with Burning Abdominal Pain
A fascinating case of a 35-year-old man with burning abdominal pain reveals the complexities of Helicobacter pylori infection. The discussion dives into its global prevalence, treatment options, and the connection to chronic gastritis and gastric ulcers. Listeners learn about the critical need for post-treatment confirmation of H. pylori eradication, highlighting the importance of tailored approaches to therapy. The episode concludes with insights into the broader implications of H. pylori on gastrointestinal health and cancer risks.

Apr 24, 2025 • 6min
Ep 143: 5 Cases for Antibiotic Prophylaxis
Explore the intriguing complexities of antibiotic prophylaxis through five real-life case studies. Delve into guidelines for various clinical scenarios, including meningococcal contacts and dental procedures. Understand the vital role of prophylactic antibiotics in surgery, with a focus on proper timing and administration of IV cefazolin. The discussion sheds light on the critical balance needed to prevent complications while combating antibiotic resistance.

Apr 17, 2025 • 8min
Ep 142: Infertility in a Couple of Reproductive Age
In this episode, we explore the causes of infertility and the recommended initial evaluation.Harrison's Principles of Internal Medicine, 22nd Edition

26 snips
Apr 10, 2025 • 9min
Ep 141: A 51-Year-Old with Stage 3 Breast Cancer
A patient with a history of stage 3 breast cancer develops new mid-back pain, sparking a deep dive into diagnosis. The discussion highlights distinguishing her symptoms from typical discomfort and includes potential causes like spinal metastasis. The hosts explore the critical nature of recognizing compressive lesions and the importance of timely treatment. MRI's role in identifying spinal metastases is emphasized, along with the unique challenges posed by metastatic breast cancer lesions in imaging and management.

Apr 3, 2025 • 9min
Ep 140: A 45-Year-Old Man with Confusion After Running
This episode discusses a patient with an elevated body temperature and explores heat-related illnesses.See more on this topic on AccessMedicineHarrison's Principles of Internal Medicine, 22nd Edition

Mar 27, 2025 • 9min
Ep 139: First Time Visit for a 73-Year-Old Man
This episode reviews primary care principles for caring for older adults.See more on this topic on AccessMedicine.Harrison's Principles of Internal Medicine, 22nd Edition

Mar 20, 2025 • 7min
Ep 138: A 67-Year-Old Male After ICD Firing
This episode covers implantable cardiac defibrillators and their management.See more on this topic on AccessMedicine.Harrison's Principles of Internal Medicine, 22nd Edition

Mar 13, 2025 • 8min
Ep 137: A 21-Year-Old with Vaginal Discharge
Dive into the intriguing case of a 21-year-old college student facing a persistent malodorous vaginal discharge. The discussion highlights the importance of STI testing while dissecting common culprits like trichomonas and bacterial vaginosis. The complexities of diagnosing infections are explored, with a sharp focus on physical examination findings. Additionally, the risks associated with bacterial vaginosis, including complications during pregnancy, are thoroughly examined. Learn about diagnostic criteria and treatment options while busting common myths surrounding these conditions.

Mar 6, 2025 • 7min
Ep 136: A 71-Year-Old Man with Prostate Cancer
A 71-year-old man's participation in a prostate cancer trial reveals fascinating insights about the placebo effect. The discussion delves into ethical considerations and informed consent, enhancing our understanding of clinical trials. It then unpacks how patient expectations inform their responses, supported by psychological studies and neuroimaging. Misconceptions about placebo controls are addressed in an engaging format, making complex concepts accessible and intriguing.