Night Science

Albert-László Barabási is a distinguished professor at Northeastern University in Boston. In this episode, he tells us how he established the field of network science. He explains the expert’s fallacy and why it’s time to move to another field once you become afraid to break things. He tells about his strategies to select research projects with his students, and that the science only really starts after the first draft has been written. He also tells us how the crucial skill to make discoveries is to sense which idea’s time has come, and how to move into a field when you think that you can bring something all of your own to the table.For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Doing science reminds Stuart Firestein of an old saying: “It’s very difficult to find a black cat in a dark room. Especially when there is no cat.” Before studying biology and becoming a professor at Columbia University in New York, Stuart worked for many years in the theater. In this episode, he talks about how he doesn’t miss the creativity or the spirit of the theater, as he finds all of that in science. For Stuart, ignorance and creativity are two horses pulling the same wagon of science, and lab meetings are center stage for both. To make progress, Stuart finds pluralism of enormous value – and crucial to pluralism is the ability to fail. For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Galit Lahav, Chair of the Systems Biology Department at Harvard Medical School, discusses her innovative approach to scientific creativity. She emphasizes the importance of vulnerability and incubation periods for fostering new ideas. Lahav advocates for the concept of Night Science Tuesday, arguing that dedicated time away from routine can enhance deep thinking. The conversation also touches on balancing motherhood with academia and the emotional challenges of abandoning projects, highlighting the need for collaborative support in research.

Eric Topol, a prominent cardiologist and founder of the Scripps Research Translational Institute, dives into the transformative impact of AI in medicine. He advocates for creative, counterintuitive thinking, revealing how innovative applications of AI, like predicting heart disease from retinal images, could revolutionize healthcare. The discussion highlights the importance of interdisciplinary collaboration and encourages scientists to embrace bold ideas and experiment with unconventional approaches. Topol emphasizes a mindset shift for young professionals to prioritize imaginative research.

Aviv Regev is what anyone would call a true science hero. She is not only a pioneer of single-cell genomics and systems biology, but also a great mentor. In 2020, she moved from her professorship at MIT and the Broad Institute to the biotech company Genentech, where she is Executive Vice President and Head of Research and Early Development. We talked with her about the advantages of setting ideas free and about how to be a generous collaborator. Aviv told us how creativity can arise from a deep frustration, and how time elasticity can help achieving it. She proposes that the scientific process involves going with the flow, but that your personal taste may channel that flow into directions that are most interesting to you.For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Cassandra Extavour is a Professor of developmental and evolutionary biology at Harvard University, and she is an Investigator at the prestigious Howard Hughes Medical Institute. Cassandra’s pioneering research focuses on how germ cells – those immortal cells that form the next generation – are specified in different animals. Cassandra is a champion for diversity and inclusivity, helping to found the Pan-American Society of Evolutionary Developmental Biology. Cassandra has a second, part-time job as a professional soprano, singing opera and Baroque music with professional ensembles around the world, and we talked with her about how creativity in science and music is similar. Our conversation with Cassandra led us to discuss how reading broadly across fields and generations forms the substrate for new ideas, and how speaking the “languages” of different fields can stimulate ideas. For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Daniel Kahneman won the Nobel Prize for Economics – as a psychologist. His fundamental work in behavioral economics revealed our cognitive biases, such as loss aversion – the fact that we react much more strongly to losses than to gains. Danny’s popular science book “Thinking, Fast and Slow” is a highly influential bestseller; Itai and Martin consider it the operating manual for the human brain. In this conversation, Danny tells us how his creative process is driven by a lack of content with what has already been achieved. Other topics we talk about include the suspension of critical weapons, why anthropomorphisms are valuable, how to give the mind something to work on while asleep, and Danny’s innovation of the ‘adversarial collaboration’.For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Peer Bork is a legendary scientist, and these days he’s also the Director of Scientific Activities at the European Molecular Biology Lab (EMBL) in Heidelberg. Among his many accolades, Peer was recently honored by the International Society for Computational Biology for "Tremendous contributions to bioinformatics on a plethora of fronts within the field". As a highly interdisciplinary scientist, Peer tells us how his team moves into new fields, adapting tools and creating new ones, and trusting their own data more than common wisdom. Peer also talks about how to hunt for nuggets of discoveries in huge datasets. His advice for starting investigators may help to build motivated and diverse teams that persevere in the face of setbacks. For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Edward Tufte, a data visualization guru and author, shares insights from his latest book, emphasizing the concept of the 'thinking eye'—the art of observing data with fresh, unfiltered curiosity. He introduces 'vacation eyes,' the idea of seeing environments anew to unlock unique perspectives. Tufte discusses his observations of heart surgeries, blending medicine and tech innovations. He also highlights the critical role of graphical representation in bridging art and data, advocating for transparency in research practices to combat publication biases.

Shafi Goldwasser received the Turing Award – the “Nobel Prize of Computing” – in 2012. She needs no introduction to anyone working in computer science or cryptology, a field she essentially founded as a theoretical discipline. Shafi is a professor at both MIT and the Weizmann Institute in Israel, as well as being the director of the Simons Institute for the Theory of Computing at Berkeley. In this episode, Shafi tells us how her favourite scientific ideas are akin to a good joke: they catch you off guard with something unexpected. We discuss how even the most abstract work almost always starts from a concrete example, and how feeling comfortable expressing your ideas is the basis of good collaborations.For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .