Mastering Nutrition

This podcast discusses the interpretation of urinary organic acid tests, focusing on the citric acid cycle metabolites. It explores the chemistry behind the absence of oxaloacetate on these tests and teaches how to identify patterns related to energy overload, oxidative stress, and thiamine deficiency. The importance of NAD plus and NADH ratios, as well as the impact of oxidative stress on enzymes, is also examined.

This lesson looks at the fundamental principle that atomic oxygen is the limiting factor for the release of carbon dioxide in metabolism, and when we don’t have enough we take it from water. This will become very relevant when we cover fats versus carbohydrates, because they consume different amounts of water and release different amounts of carbon dioxide for this very reason. That, in turn, relates to a number of health endpoints such as the functions of vitamin K and biotin, delivery of oxygen to tissues, and the stress placed on the lungs during breathing. Here, we look at the principle in the citric acid cycle. In doing so, we see that, while textbooks only point to two water molecules consumed, a third water molecule is irreversibly consumed to donate oxygen to the cycle via phosphate. For the full lesson, go to chrismasterjohnphd.com/mwm/2/7 Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

This podcast explores the role of Coenzyme A in the citric acid cycle, discussing the formation of thioester bonds, resonance stabilization of chemical bonds, and how CoA helps with energy storage and release. It also delves into the function of succinyl-CoA synthetase in producing ATP or GTP based on tissue energy requirements.

This podcast explores the biochemistry and relevance of α-Ketoglutarate Dehydrogenase Complex. It covers topics such as energetic coupling, substrate channeling, oxidative stress, heavy metal poisoning, Alzheimer's disease, odd-chain fatty acids, heme synthesis, vitamins B12 and B6 deficiencies, and sideroblastic anemia.

Exploring the role of alpha-ketoglutarate dehydrogenase in the citric acid cycle and the significance of thiamine. Thiamine attracts carbon-containing molecules and facilitates decarboxylation reactions. Delving into the transfer process of hydrogen ions and electrons in the citric acid cycle, highlighting the role of enzymes and co-factors like thiamine, lipoate, and FAD.

Are you interested in working with me one-on-one so I can help you better meet your health goals? Good news! I’m now accepting new clients for both hourly consultations and health and wellness packages. Here are the core things I’m best at that I would love to do for you: Help you develop actionable priorities and an overall strategy for improving your health. Discuss your experiences with you and suggest useful tests that you could ask your doctor about. Analyze the results of genetic tests, digital food logs, and blood and urine measurements for markers of health and nutritional status. I can then use these analyses to suggest practical strategies that you could implement with proper supervision of a health care professional. If you want to want to read more about what I have to offer, head over to the main consultations page: Health and Wellness Consultations With Chris Masterjohn, PhD Although I have no plans to expire the offer, I suggest you act rather swiftly if you want to book sessions between now and February because the spots available from September through January are limited and will fill up fast. After February, my availability is much more open.  Once again, here are the links you may need: learn more about what I have to offer. Book an hourly session. Book a health and wellness package. Whether sooner or later, I look forward to working with you and helping you fulfill your health goals. If you have any questions about how this works, please do not hesitate to email me at chris [at] chrismasterjohnphd {dot} com.

If you develop dry skin on a low-fat diet, especially if you're eating egg whites and throwing out the yolks, it could be a biotin deficiency. Or, it could be an essential fatty acid deficiency. Either way, egg yolks and liver come to the rescue. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here.

This podcast delves into the isocitrate dehydrogenase in the citric acid cycle, its unique decarboxylation reaction without thiamine, and the implications for burning carbohydrate and fat for fuel. It also explores the interconversion of amino acids and citric acid cycle intermediates, the role of vitamin B6, and the use of transaminases to diagnose B6 deficiency and liver dysfunction.

Do you get dry skin when you put on muscle mass? It could be a zinc deficiency. Here's how to take care of it. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here.

This podcast explores the regulation of ATP production in cells. It covers the role of AMP kinase in promoting energy uptake when ATP levels are low. The chapters discuss the principles of reactant concentration, allosteric regulation, and the balance of ATP and other regulators in the citric acid cycle. It also explores how cells regulate ATP production based on their energy status, including the role of intermediates and AMP kinase.