Mastering Nutrition

This podcast explores the regulation of glycolysis and its key enzymes. It discusses how energy status governs the burning of glucose for energy, the role of the pentose phosphate pathway, and the storage of excess glucose as glycogen. The regulation of pyruvate kinase is also highlighted, along with the balance between glycolysis and gluconeogenesis.

This podcast explores beta-oxidation, comparing it to carbohydrate oxidation and explaining the steps involved. It also discusses the role of NAD+ and FAD in the process and the formation of acetyl-CoA. Learn more about fatty acid oxidation and access premium features.

This podcast explores the process of glycolysis, diving into the energy investment and energy generation phases, substrate-level phosphorylation, ATP production, and water consumption. It delves into the misleading stoichiometry of glycolysis and explains why glycolysis is net water-neutral. Find out more about this fascinating process by accessing the full episode and premium features on chrismasterjohnphd.com.

Can fat fuel intensity in a competitive athlete? This lesson takes a critical look at the commonly cited evidence in favor of a neutral or beneficial effect of low-carbohydrate or ketogenic diets on sports performance, as well as key pieces of conflicting evidence. Bottom line? Fat can fuel duration, but probably can never fuel your peak intensity, just as the physiology would predict. For the full episode, go to chrismasterjohnphd.com/mwm/2/18 Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

Can athletes fat-adapt their workouts? This lesson lays down the principles of exercise biochemistry and physiology needed to understand the importance of the three energy systems supporting energy metabolism in skeletal muscle: the phosphagen system (ATP and creatine), anaerobic glycolysis (dependent on carbs), and oxidative phosphorylation (dependent on carbs, fat, or protein). We discuss why maximal intensity always depends on carbs if the intensity and duration are sufficient to deplete phosphocreatine concentrations, and clarify the window of time and intensity that can be fat-adapted. This sets the foundation for the next lesson, which looks at the evidence of how carbohydrate restriction and ketogenic diets impact sports performance. For the full episode, go to chrismasterjohnphd.com/mwm/2/17 Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

This podcast explores the concept of anaplerosis and its importance in the citric acid cycle. It discusses how carbs and protein are the primary sources of anaplerosis, and how carbs can spare the need for protein. The podcast also delves into the limited contribution of fatty acids in anaplerosis compared to carbs and protein. Furthermore, it explores the role of carbohydrates, fat, and anaplerosis in energy metabolism, including the importance of protein goals in a ketogenic diet.

This podcast discusses the importance of lactate in energy production, the relationship between ADP and NAD+ in glycolysis, the production of lactate and the Cori Cycle, and the liver's role in providing energy through anaerobic glycolysis. It also explores the role of carbohydrates in supporting these processes.

Thiamin deficiency can be caused by the environment, including thiamin-destroying amoebas, bacteria, and fungi. Thiamin supplementation may help with glucose intolerance. Ketogenic diets spare thiamin and can treat neurological disorders. Fat contains little thiamin, so caution must be exercised on ketogenic diets. The podcast explores the link between thiamin, glucose tolerance, and neurological conditions.

This podcast explores the pyruvate dehydrogenase complex and its role in energy metabolism, highlighting the differences between carbohydrate and fat metabolism. It discusses the similarities between alpha-ketoglutarate dehydrogenase complex and pyruvate dehydrogenase complex, emphasizing the importance of thiamine in these processes. The chapter also explores vulnerabilities to oxidative stress and heavy metal toxicity, and discusses low carbohydrate diets and thiamine supplementation.

This podcast discusses the differences in carbon dioxide and water production between carbohydrate and fat metabolism. It explores how these differences affect lung function and healing, and highlights the benefits of a high fat, low carbohydrate diet. Additionally, the podcast delves into the importance of carbon dioxide in supporting various bodily functions and delivering oxygen to muscles during exercise.