Mastering Nutrition

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: Protein and Longevity  Why is an IV more hydrating than salted water? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn’t win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn’t hydrate, tics and Tourette’s, recalcitrant homocysteine, fraud and corruption in scienctific research. Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august Access the show notes, transcript, and comments here.

I am done with my work on COVID vaccines, at least until I finish my Vitamins and Minerals 101 Book, so I am now making my scientific review on the likely causes of COVID vaccine side effects public. This is an excerpt of pages 19-52 of my Healing From COVID Vaccine Side Effects guide (free to Masterpass members here). You can read the written version on Substack using this link, which contains 139 of the 221 references. It does not contain the protocol, but rather the scientific review used to judge the mechanisms most likely underlying the side effects. Since I am no longer working on this, I hope it proves useful to anyone doing further work on the topic. This was originally published on August 10, 2022. The science described is not intended to be comprehensive. Rather, emphasis is placed on what is likely to provide insights into the mechanisms of side effects. Please visit the Substack version to like it, comment on it, and share it: COVID Vaccine Side Effects: What Causes Them? Join the Next Live Q&A Have a question for me? Ask it at the next Q&A! Learn more here. Join the Masterpass Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Learn more about the Masterpass here. Take a Look at the Store At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements, MASA chips. Find more affiliates here. For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science. For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick. For $10, you can purchase Healing From COVID Vaccine Side Effects for yourself or a loved one if dealing with this issue. It also contains an extensive well-referenced scientific review, so you can also use this just to learn more about my research into the COVID vaccines. For $15, you can pre-order a single format of my Vitamins and Minerals 101 book, my complete guide to nutrition, which I am currently working full-time on finishing. For $25, you can pre-order a digital bundle of my Vitamins and Minerals 101 book. For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork. For $35, you can pre-order a complete bundle of my Vitamins and Minerals 101 book. For $250-$1499.99, you can work one-on-one with me.

Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of protein or calories might otherwise provide, and a high protein intake supports bone mass, muscle mass, and the detoxification of carcinogens, all of which are important to longevity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: How to Increase or Decrease SHBG?  Why is an IV more hydrating than salted water? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn’t win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn’t hydrate, tics and Tourette’s, recalcitrant homocysteine, fraud and corruption in scienctific research. Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august Access the show notes, transcript, and comments here.

Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal What is my favorite web site for finding enzymatic cofactors Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won’t go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3 Access the show notes, transcript, and comments here.

The podcast discusses the three phases of fasting and the transition from a fasted state to a fed state. It explores the depletion of liver glycogen and the shift to using ketones as fuel. The role of body signaling in transitioning between fasting states is also explained, along with the importance of preparatory signals when consuming food. The different stages of fasting and the changes that occur in the body during each phase are highlighted, including hepatic glycogen, gluconeogenesis, and ketones.

Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don’t at doses used. Human effect on PSA is vulnerable to regression to the mean and thoroughly unconvincing.   This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the June 16, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included: What to do about persistent SIBO? Are there toxicity concerns for intravenous B vitamins? Should zinc be taken apart from oral rehydration salts? Why would magnesium cause erratic heartbeat, bad dreams, and tinnitus? How do you know if you have low stomach acid? What is a good sweetener to replace granulated sugar? Do I need to eat foods with calcium every day? What bread do I eat? Should you take vitamin D for COVID prevention if you have a history of hypercalcemia? What to do about extreme CFS, depression, anxiety, and brain fog when nothing seems to work. Why balance K2 with vitamin E rather than K1? Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june Access the show notes, transcript, and comments here.

Short answer: Trust the CGM. HbA1c is confounded by red blood cell turnover and fructosamine 3-kinase activity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the June 16, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included: What to do about persistent SIBO? Are there toxicity concerns for intravenous B vitamins? Should zinc be taken apart from oral rehydration salts? Why would magnesium cause erratic heartbeat, bad dreams, and tinnitus? How do you know if you have low stomach acid? What is a good sweetener to replace granulated sugar? Do I need to eat foods with calcium every day? What bread do I eat? Should you take vitamin D for COVID prevention if you have a history of hypercalcemia? What to do about extreme CFS, depression, anxiety, and brain fog when nothing seems to work. Why balance K2 with vitamin E rather than K1? Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june Access the show notes, transcript, and comments here.

My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new tortilla chip that launches today! MASA chips are made from organic corn from small New England farms. The corn is nixtimalized, which frees the niacin, makes it more digestible, and eliminates 97-100% of the mycotoxins (based on studies with aflatoxin). Then they are fried in grass-fed beef tallow! They are full-bodied and feel nourishing, and they are the perfect saltiness. That is, I do not feel like a company has tagged me as eating a low-salt diet just because I want a healthy chip. The bulk of your diet should be unprocessed and minimally processed foods, but there is an important place for health snacks! Get your MASA chips today at https://chrismasterjohnphd.com/masa and use the code MASTERJOHN for 10% off. I will get a small commission at no extra cost to you. You will rarely ever find me promoting a chip, but this is one I endorse!

Nick Hiebert and I debate the value of ancestral health as a framework for approaching health in the modern era. For my summary of and reflections on the debate, as well as time stamps, relevant links, and a transcript, head to: https://chrismasterjohnphd.substack.com/p/the-ancestral-health-debate If you found this valuable, please like, share, and comment on the Substack version to get it before more eyeballs.

In this interview, Mathew Crawford walks me through his slide presentation of data showing that, at some point between 2020 and 2021, the 2016-2019 data from the US Military’s health database was altered in a way that hides the explosion of poorly-defined illness among troops that happened in 2021 as the COVID vaccines were rolled out. For the video with the slides, a more complete summary, and a transcript, head over to Substack with this link: https://chrismasterjohnphd.substack.com/p/mathew-crawford-fraud-in-the-militarys If you find this valuable, please like, share, and comment on the Substack video to help me promote this before more eyeballs by leveraging the Substack algorithm. Please need to see this!