Mastering Nutrition

I'm not sure what the best dosing is given that it hasn't actually been studied fully, but I believe that it was estimated that in the people who have the highest collagen waste during collagen turnover that they can run short of glycine about 60 grams a day whereas I believe the more conservative estimate of glycine requirements based on people that turnover collagen much more efficiently.I would say that as a general rule, you should assume that you want something spread out as much as possible rather than the reverse if you don't have the data showing that it’s okay or better to have it all at once because wherever there is data or wherever there is a plausible rationale, it's almost always the case that it's better to have it spread out. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations  DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Where should I buy my chicken products? You may have local options. And a good place to look for local options would be eatwild.com. I’m assuming it’s still up. That was a great database and probably still is a great database of pasture-raised products of any type. Not just chicken. And then of course, there are the mail order companies that I have exclusive discounts with inside the Masterpass program, most of which sell chicken products. So, White Oak Pastures, North Star Bison who focuses on bison but I believe they have chicken also. And U.S. Wellness whereas  chicken might not be their main thing, I’m pretty sure they have chicken. Generally those companies, even if they don’t advertise themselves as mainly being about chicken, they usually will have some chicken. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations  DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

I don't usually interview people on my podcast, but this is an important exception and I'd appreciate it if you'd share it far and wide. Here's the YouTube version: COVID Conversations: Gabriela Gomes on Herd Immunity Gabriela Gomes is Professor of Mathematics and Statistics at University of Strathclyde Glasgow and corresponding author of the recent paper, "Herd immunity thresholds for SARS-CoV-2 estimated from unfolding epidemics," one of the papers arguing that the herd immunity threshold is on the order of 10-20% in the European communities they studied rather than the 60-80% more commonly cited, and she's here to talk about herd immunity and COVID-19. Here's a list of topics we covered: 00:00:01 Introduction 00:01:28 Gabriela's body of research showing the importance of individual variation in susceptibility to infectious diseases. 00:04:25 Conventional models that don't take into account individual variation overestimate the size of epidemics and overestimate the effect of interventions. 00:05:21 How has her research been received by her colleagues? 00:09:30 The evolution of immunity has to be through the action of natural selection on variation, making it logically necessary that variation exists. 00:11:54 Nutrition scientists underestimated variation in nutritional requirements but have been much more receptive than infectious disease epidemiologists to incorporating it into their models. 00:15:51 The ability to identify a single necessary factor in infectious disease spread has biased the field toward a ground-up mechanistic model to vet the inclusion of variables. 00:22:34 What is herd immunity? 00:26:11 Tuberculosis disappeared because socioeconomic conditions improved. 00:29:06 Until the vaccine, measles cycled in and out of herd immunity as new infants entered the susceptible population. 00:31:13 Measles is much more transmissible than SARS-CoV-2. 00:32:21 SARS was contained before it had a chance to spread. 00:34:08 Herd immunity is not the end of concern about a disease. 00:34:33 The herd immunity threshold for COVID will be crossed many times, but crossing it the first time is the end of the "pandemic phase." 00:39:16 The seasonality of the flu is influenced not only by weather and social patterns that influence transmissibility, but also by cyclically crossing in and out of herd immunity. Viral mutations can be the trigger to temporarily cycle out of herd immunity. 00:46:57 Why conventional herd immunity threshold calculations say the threshold is 60-80% for COVID, but why Gabriela's model says 10-20%. 00:51:45 How do we know what the degree of variation is? 00:54:56 Gabriela's conclusions are similar to those reached by other researchers when looking at NYC and Chicago. 00:56:48 As long as susceptibility is correlated to infectiousness, natural infections will remove the most infectious people early on. 01:01:26 Is it possible that lockdowns and social distancing are solely responsible for everything we attribute to herd immunity? 01:08:30 How likely is it that fading immunity and reinfection would render the herd immunity model useless? 01:11:19 What does the New York City data tell us about herd immunity and reinfection? 01:15:32 What does Spain's second wave tell us? 01:19:21 We discuss Harvard Professor Miguel Hernán's suggestion on Twitter that NYC is doing so much better than Madrid because NYC had superior testing, contact tracing, and phased reopening. 01:23:16 Misunderstanding herd immunity has huge economic consequences. 01:25:13 Should we be looking at cases, hospitalizations, deaths, or seroprevalence as our primary metric? 01:35:28 We discuss University of Minnesota epidemiologist Michael Osterholm's suggestion that scientists modeling a 20% herd immunity threshold are "not connected with real-world thinking" and that the much higher infection rates in prisons and a South Korean call center show that the herd immunity threshold cannot be anywhere near as low as 20%. 01:41:05 Gabriela is hoping to find more collaborators to extend the modeling to more communities. 01:41:55 Why approaching herd immunity rapidly allows you to massively overshoot the threshold 01:46:10 How has her research been received by peer review, the press, and her colleagues? 01:49:00 What developments will she be looking for that would falsify her model? 01:50:39 What are the policy implications of her research? Here's how you can share this on social media: Retweet it on Twitter Heart it on Instagram Share it on Facebook Stay safe and healthy, Chris

Read the written version here, with links to the original references: https://chrismasterjohnphd.com/covid-19/are-we-already-reaching-herd-immunity Sign up for the free newsletter: https://chrismasterjohnphd.com/covid19-updates  Discuss this in the Masterpass Free Forum at https://chrismasterjohnphd.com/discuss  Discuss this in the Coronavirus Forum when you purchase the guide, pre-order my upcoming book, or join the CMJ Masterpass. Support the service by purchasing a copy of The Food and Supplement Guide for the Coronavirus: https://chrismasterjohnphd.com/coronavirus  Get the guide for free when pre-ordering my Vitamins and Minerals 101 book: https://chrismasterjohnphd.com/book  Get the guide for free and get 30-50% off the pre-orders of my book when you sign up for the CMJ Masterpass: https://chrismasterjohnphd.com/masterpass  DISCUSS! Here are three ways to discuss this topic, including asking me questions and getting a response: The Masterpass FREE Forum. This forum is free and open to anyone to participate. Anything related to health and nutrition, including all aspects of the coronavirus, is welcome. I will do my best to participate several times a week, though I expect this to eventually be very large and may at some point have to participate on a weekly basis if it starts to take on a life of its own. Join for free at chrismasterjohnphd.com/discuss The Coronavirus Forum. This is for anyone who purchases The Food and Supplement Guide for the Coronavirus, pre-orders my upcoming Vitamins and Minerals 101 book, or joins the CMJ Masterpass (if you join, use the coupon code COVID19 for 10% off the membership price). This forum is dedicated specifically to the coronavirus, has subsections based on topics (nutrition, medicine, lifestyle, mechanisms of disease), and has a section where the archive version of this newsletter is directly linked and each newsletter can be discussed as an individual thread. I consistently participate in this forum 3-5 times a week. Purchase the guide at chrismasterjohnphd.com/coronavirus The Masterpass Discussion Group. Preserved for those who join the CMJ Masterpass, it's the best place to ask me questions in a fairly intimate environment and get a rapid response. All topics I cover are fair game, and I consistently participate approximately five times per week. The Masterpass also has monthly live Zoom Q&As that are even more intimate. Join the Masterpass at chrismasterjohnphd.com/masterpass SUPPORT These research updates are made possible by purchases of The Food and Supplement Guide to the Coronavirus. The guide contains my most up-to-date conclusions about what we should be doing for nutritional and herbal support on top of hygiene and social distancing for added protection. Due to the absence of randomized controlled trials testing nutritional or herbal prevention, these are my best guesses for what is likely to work without significant risk of harm, based on the existing science. By purchasing the guide, you are enabling me to continue devoting my skills to the most important issue we now face. I am genuinely grateful for your contribution. You can purchase a copy at chrismasterjohnphd.com/coronavirus You can get the guide for free if you pre-order my upcoming book, Vitamins and Minerals 101: How to Get the Nutrients You Need on Any Diet (to be released when the COVID-19 crisis subsides). You can pre-order it at chrismasterjohnphd.com/book You can also get the guide free when you join the CMJ Masterpass, which is meant to help people with significant health and wellness expenditures consistently save money by returning marketing cost of the companies involved back to the members as rebates. A membership also saves you 30% on pre-orders of the paperback and 50% on pre-orders of the digital versions of my book. You can sign up at chrismasterjohnphd.com/masterpass SUBSCRIBE This series is based on my free daily newsletter, COVID-19 Research Updates. As a result of the time it takes to produce an video or podcast from a newsletter I wrote up, there's a slight delay between when I publish the newsletter and when you watch or listen to this. When you subscribe to the newsletter, you get the latest of my research every single day as soon as it's ready to come out. You get references and links to the sources for all the information, and you immediately get an archive of all the past issues. You can sign up at chrismasterjohnphd.com/covid19-updates DISCLAIMER I am not a medical doctor and this is not medical advice. I am also not an infectious disease epidemiologist and I am not speaking on behalf of infectious disease epidemiologists. I have a PhD in Nutritional Sciences and my expertise is in conducting and interpreting research related to my field. Please consult your physician before doing anything for prevention or treatment of COVID-19, and please seek the help of a physician immediately if you believe you may have COVID-19. STAY SAFE AND HEALTHY!

Question: Why would blood glucose go up on a low-carb diet? When you're adapted to low insulin levels with lower GLUT expression, but you want to get glucose into muscle, you're going to need higher blood glucose levels to do it. I think elevated blood glucose is sufficiently known to be pathological that it would be unwise to assume the sort of more generous interpretation of that as a physiological response. I think it would be a much better approach to do what you need to do to get your blood glucose levels into the healthy range. Otherwise, I think it's quite a gamble to presume innocence of that elevated blood glucose. This Q&A can also be found as part of a much longer episode, here. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. There are two ways to discuss this episode: Discuss it in The Masterpass FREE Forum, which is freely open to everyone, at https://chrismasterjohnphd.com/discuss If you’re a Masterpass member, discuss it in the Masterpass Discussion Group, found in your dashboard. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Why do thyroid levels drop on a low-carb diet? So insulin and leptin are both positive regulators of thyroid hormone, production, and conversion. And generally I do think there's probably a larger effect from thyroid production than peripheral conversion. I'm not too sure about that, but insulin does directly regulate thyroid. It has TSH-like effects on the thyroid gland. It doesn't replicate all of TSH's effects, but it does replicate a portion of them. So basically, more or less, have like TSH amplification with insulin. This Q&A can also be found as part of a much longer episode, here. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. There are two ways to discuss this episode: Discuss it in The Masterpass FREE Forum, which is freely open to everyone, at https://chrismasterjohnphd.com/discuss  If you’re a Masterpass member, discuss it in the Masterpass Discussion Group, found in your dashboard. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Sign up for the free newsletter: https://chrismasterjohnphd.com/covid19-updates  Discuss this in the Masterpass Free Forum at https://chrismasterjohnphd.com/discuss  Discuss this in the Coronavirus Forum when you purchase the guide, pre-order my upcoming book, or join the CMJ Masterpass. Support the service by purchasing a copy of The Food and Supplement Guide for the Coronavirus: https://chrismasterjohnphd.com/coronavirus  Get the guide for free when pre-ordering my Vitamins and Minerals 101 book: https://chrismasterjohnphd.com/book  Get the guide for free and get 30-50% off the pre-orders of my book when you sign up for the CMJ Masterpass: https://chrismasterjohnphd.com/masterpass  DISCUSS! Here are three ways to discuss this topic, including asking me questions and getting a response: The Masterpass FREE Forum. This forum is free and open to anyone to participate. Anything related to health and nutrition, including all aspects of the coronavirus, is welcome. I will do my best to participate several times a week, though I expect this to eventually be very large and may at some point have to participate on a weekly basis if it starts to take on a life of its own. Join for free at chrismasterjohnphd.com/discuss The Coronavirus Forum. This is for anyone who purchases The Food and Supplement Guide for the Coronavirus, pre-orders my upcoming Vitamins and Minerals 101 book, or joins the CMJ Masterpass (if you join, use the coupon code COVID19 for 10% off the membership price). This forum is dedicated specifically to the coronavirus, has subsections based on topics (nutrition, medicine, lifestyle, mechanisms of disease), and has a section where the archive version of this newsletter is directly linked and each newsletter can be discussed as an individual thread. I consistently participate in this forum 3-5 times a week. Purchase the guide at chrismasterjohnphd.com/coronavirus The Masterpass Discussion Group. Preserved for those who join the CMJ Masterpass, it's the best place to ask me questions in a fairly intimate environment and get a rapid response. All topics I cover are fair game, and I consistently participate approximately five times per week. The Masterpass also has monthly live Zoom Q&As that are even more intimate. Join the Masterpass at chrismasterjohnphd.com/masterpass SUPPORT These research updates are made possible by purchases of The Food and Supplement Guide to the Coronavirus. The guide contains my most up-to-date conclusions about what we should be doing for nutritional and herbal support on top of hygiene and social distancing for added protection. Due to the absence of randomized controlled trials testing nutritional or herbal prevention, these are my best guesses for what is likely to work without significant risk of harm, based on the existing science. By purchasing the guide, you are enabling me to continue devoting my skills to the most important issue we now face. I am genuinely grateful for your contribution. You can purchase a copy at chrismasterjohnphd.com/coronavirus You can get the guide for free if you pre-order my upcoming book, Vitamins and Minerals 101: How to Get the Nutrients You Need on Any Diet (to be released when the COVID-19 crisis subsides). You can pre-order it at chrismasterjohnphd.com/book You can also get the guide free when you join the CMJ Masterpass, which is meant to help people with significant health and wellness expenditures consistently save money by returning marketing cost of the companies involved back to the members as rebates. A membership also saves you 30% on pre-orders of the paperback and 50% on pre-orders of the digital versions of my book. You can sign up at chrismasterjohnphd.com/masterpass SUBSCRIBE This series is based on my free daily newsletter, COVID-19 Research Updates. As a result of the time it takes to produce an video or podcast from a newsletter I wrote up, there's a slight delay between when I publish the newsletter and when you watch or listen to this. When you subscribe to the newsletter, you get the latest of my research every single day as soon as it's ready to come out. You get references and links to the sources for all the information, and you immediately get an archive of all the past issues. You can sign up at chrismasterjohnphd.com/covid19-updates DISCLAIMER I am not a medical doctor and this is not medical advice. I am also not an infectious disease epidemiologist and I am not speaking on behalf of infectious disease epidemiologists. I have a PhD in Nutritional Sciences and my expertise is in conducting and interpreting research related to my field. Please consult your physician before doing anything for prevention or treatment of COVID-19, and please seek the help of a physician immediately if you believe you may have COVID-19. STAY SAFE AND HEALTHY!

Question: Is hydrogen sulfide produced in the gut a bad thing, and what to do about it?I agree that most people that have this problem have some kind of deranged sulfur metabolism, but I don't see why that makes it a physiological adaptation rather than a pathological condition. The correlation is probably a direct result of the predominance of sulfur-metabolizing bacteria in the gut, which is a bad thing that is actually causing the derangement of sulfur metabolism. Well, you could go the antibiotic route. And I think metronidozole, and let me see if I can dig this up quickly because I have done a lot of research on this issue for one of my clients. Okay. So from the research I was looking at, metronidozole is very effective against sulfur-metabolizing bacteria. But isn't that reliably delivered to the stool and maybe could be used as an enema. But I think generally, it is used. And then I think there's one other one that's sometimes used. I forgot what the other one is. I think it's... Okay. I can't find it. Anyway, you can go the antibiotic route under the guidance of a prescribing specialist. This Q&A can also be found as part of a much longer episode, here. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. There are two ways to discuss this episode: Discuss it in The Masterpass FREE Forum, which is freely open to everyone, at https://chrismasterjohnphd.com/discuss  If you’re a Masterpass member, discuss it in the Masterpass Discussion Group, found in your dashboard. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: What if low-carb makes me wake up to pee?  I would start by looking at your blood sugar. So I do think it's possible that if your blood sugar. Second of all, it's stimulated by salt. So salt at night might help. Third of all, in order to make it you need copper, vitamin C, and zinc. And then, fourth of all, you need, going past that, I also suggest trying to get deeper sleep. You might want to look at the quality of your sleep. So, I do think generally carbs help people get better sleep, but I do think that a ketogenic diet elevates GABA. And so I think there's a subset of people who would get better and deeper sleep on keto because of the increased brain GABA.This Q&A can also be found as part of a much longer episode, here.  If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. There are two ways to discuss this episode: Discuss it in The Masterpass FREE Forum, which is freely open to everyone, at https://chrismasterjohnphd.com/discuss  If you’re a Masterpass member, discuss it in the Masterpass Discussion Group, found in your dashboard. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Watch the YouTube video to see the slides: https://youtu.be/Az0f6VPaEAA Sign up for the free newsletter: https://chrismasterjohnphd.com/covid19-updates  Discuss this in the Masterpass Free Forum at https://chrismasterjohnphd.com/discuss  Discuss this in the Coronavirus Forum when you purchase the guide, pre-order my upcoming book, or join the CMJ Masterpass. Support the service by purchasing a copy of The Food and Supplement Guide for the Coronavirus: https://chrismasterjohnphd.com/coronavirus  Get the guide for free when pre-ordering my Vitamins and Minerals 101 book: https://chrismasterjohnphd.com/book  Get the guide for free and get 30-50% off the pre-orders of my book when you sign up for the CMJ Masterpass: https://chrismasterjohnphd.com/masterpass  DISCUSS! Here are three ways to discuss this topic, including asking me questions and getting a response: The Masterpass FREE Forum. This forum is free and open to anyone to participate. Anything related to health and nutrition, including all aspects of the coronavirus, is welcome. I will do my best to participate several times a week, though I expect this to eventually be very large and may at some point have to participate on a weekly basis if it starts to take on a life of its own. Join for free at chrismasterjohnphd.com/discuss The Coronavirus Forum. This is for anyone who purchases The Food and Supplement Guide for the Coronavirus, pre-orders my upcoming Vitamins and Minerals 101 book, or joins the CMJ Masterpass (if you join, use the coupon code COVID19 for 10% off the membership price). This forum is dedicated specifically to the coronavirus, has subsections based on topics (nutrition, medicine, lifestyle, mechanisms of disease), and has a section where the archive version of this newsletter is directly linked and each newsletter can be discussed as an individual thread. I consistently participate in this forum 3-5 times a week. Purchase the guide at chrismasterjohnphd.com/coronavirus The Masterpass Discussion Group. Preserved for those who join the CMJ Masterpass, it's the best place to ask me questions in a fairly intimate environment and get a rapid response. All topics I cover are fair game, and I consistently participate approximately five times per week. The Masterpass also has monthly live Zoom Q&As that are even more intimate. Join the Masterpass at chrismasterjohnphd.com/masterpass SUPPORT These research updates are made possible by purchases of The Food and Supplement Guide to the Coronavirus. The guide contains my most up-to-date conclusions about what we should be doing for nutritional and herbal support on top of hygiene and social distancing for added protection. Due to the absence of randomized controlled trials testing nutritional or herbal prevention, these are my best guesses for what is likely to work without significant risk of harm, based on the existing science. By purchasing the guide, you are enabling me to continue devoting my skills to the most important issue we now face. I am genuinely grateful for your contribution. You can purchase a copy at chrismasterjohnphd.com/coronavirus You can get the guide for free if you pre-order my upcoming book, Vitamins and Minerals 101: How to Get the Nutrients You Need on Any Diet (to be released when the COVID-19 crisis subsides). You can pre-order it at chrismasterjohnphd.com/book You can also get the guide free when you join the CMJ Masterpass, which is meant to help people with significant health and wellness expenditures consistently save money by returning marketing cost of the companies involved back to the members as rebates. A membership also saves you 30% on pre-orders of the paperback and 50% on pre-orders of the digital versions of my book. You can sign up at chrismasterjohnphd.com/masterpass SUBSCRIBE This series is based on my free daily newsletter, COVID-19 Research Updates. As a result of the time it takes to produce an video or podcast from a newsletter I wrote up, there's a slight delay between when I publish the newsletter and when you watch or listen to this. When you subscribe to the newsletter, you get the latest of my research every single day as soon as it's ready to come out. You get references and links to the sources for all the information, and you immediately get an archive of all the past issues. You can sign up at chrismasterjohnphd.com/covid19-updates DISCLAIMER I am not a medical doctor and this is not medical advice. I am also not an infectious disease epidemiologist and I am not speaking on behalf of infectious disease epidemiologists. I have a PhD in Nutritional Sciences and my expertise is in conducting and interpreting research related to my field. Please consult your physician before doing anything for prevention or treatment of COVID-19, and please seek the help of a physician immediately if you believe you may have COVID-19. STAY SAFE AND HEALTHY!