Mastering Nutrition

Question: Are the concerns about cyanocobalamin exaggerated? I'm not sure what people have said about the dangers. I know that I have been a critic of cyanocobalamin relative to other forms of B12 and then, other people may have used something I said maybe in an exaggerated way. And then there might be just much marketing that I haven't actually been exposed to where people have come up with their own marketing claims around other forms of B12. So my opinion is basically as follows: number one, the amount of cyanide that would be released from taking even high doses of cyanocobalamin is very small. And so I don't think taking cyanocobalamin is dangerous in any context that I can think of so that's number one. But number two, one of our mechanisms for detoxifying cyanide, and it's not the only mechanism, but it's one of the key mechanisms is to join the cyanide, to cobalamin, to pee it out in the urine.Reference: https://www.sciencedirect.com/science/article/abs/pii/S0026049505001897?via%3Dihub If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: What's a better nasal spray, Sterimar or povidone-iodine? It's hard to say. So the Povidone-iodine obviously has some contraindications and it has contraindications mostly because it's been so commonly used in a medical setting and therefore has so much known about its safety and risk profile and I don't have any particular reason to think that the Sterimar is unsafe in any context. And I used it a lot. The only thing I can say anecdotally is I've used the Povidone-iodine intra nasally, and I've used the Sterimar spray intra nasally. And I feel like 0.5% Povidone-iodine is really powerful in wiping out anything we have going on in the nose. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: Do postmenopausal women need to worry about iron overload?Generally, it's not men who are necessarily predisposed to iron buildup. It's men with some genetic predisposition to that, so maybe less than 10% of men. But yeah, postmenopausal women with the same genetics will, like men, be vulnerable to that. When you stop menstruating, you essentially become like a man in terms of your ability to accumulate iron. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: Should NAC supplementation be pulsed?So, yes, boost glutathione. It might bring glutathione down. It's speculative that you could pulse it to avoid that. But even supplementing oral glutathione for 6 months was shown to not affect glutathione production. And certainly, oral glutathione is going to have more of a negative feedback loop than a glutathione precursor. So, I am not too worried about it. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: Why would my threonine levels be low? The two things I can think of are increased gluconeogenesis and increased conversion of methylglyoxal, both of which I would expect to be driven by a low carbohydrate diet. Then of course, it could also be not enough protein consumption. But if it's why threonine is being metabolized, I'm gonna be thinking of a low carbohydrate diet. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: What's the best alcohol to microdose? I prefer red wine on a taste, and tradition, and aesthetic basis. Just for background, I think Half a drink to a drink a day is probably the net maximal benefit for alcohol and that can be averaged. It doesn't have to be every day. And that's the main thing. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Explore how methylation can significantly influence mental flexibility and its connection to panic and anxiety. Discover the role of dopamine in regulating mental responses and enhancing resilience against anxiety. The discussion combines both nutritional and non-nutritional strategies, emphasizing a holistic approach to mental wellness. Listeners will gain insights into the best nutrients for managing anxiety while learning practical tips to improve their overall mental health.

Question: What determines the absorption of nutrients? This is a gigantic question because what determines the absorption of any given nutrient is independent for that nutrient. And so, it's different for every nutrient. And we just don't have that level of data to drive modeling of absorption of other nutrients in an accurate way. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: Do low serine levels require IV supplements?You're probably just depleting serine through the CBS pathway and just eat more protein and consider supplementing glycine or collagen along with it. I don't see why that would require IV supplements. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: How to fix high iron and calcium, low copper and magnesium, without blood donation? Your only options for decreasing iron levels are to eat a low meat vegetarian diet high in vegetables, nuts, seeds, and whole grains. That's probably your best bet. But the thing is, a very vegetable rich diet is gonna be pretty high in copper. And it's going to be high in iron too, but it's gonna be very poorly absorbable iron. And you know, especially if you eat a lot of whole grains, nuts, seeds, and legumes, you can get a lot of phytate. When doing that, you should probably supplement with zinc. You could consider supplementing with copper. The preferred copper for me would be liver or liver capsules, which I think provide copper way out sized to the iron that they provide. I think that's your best option when you don't have giving blood as an option to get rid of iron. If needed, you can do supplemental phytate, but I would use that as a last resort rather than a first one. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.