The Dr. Layne Norton Podcast

Layne Norton
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Oct 26, 2026 • 60min

Insulin: An Undeserved Bad Reputation

Is insulin truly the villain behind weight gain? This discussion explores insulin’s real metabolic roles, the carbohydrate-insulin model of obesity, and what metabolic ward trials, feeding studies, meta-analyses, population data, and DIETFITS reveal about low-carb versus low-fat diets. It also examines overfeeding, type 2 diabetes, and why GLP-1 medications complicate the insulin-centered story.
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48 snips
Oct 12, 2026 • 30min

Overrated/Underrated: Longevity & Biohacking Edition

Which longevity trends deserve attention, and which are mostly hype? This evidence-focused discussion weighs VO2 max, grip strength, muscle mass, steps, Zone 2 cardio, cold plunges, sauna, sleep trackers, fasting, biological age tests, full-body MRI, ApoB, blood work, and stress management.
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30 snips
Sep 28, 2026 • 1h 18min

The Science of Fitness Misinformation: Why Smart People Believe Dumb Things

Why do detoxes, seed oils, cortisol, sweeteners, and hormone claims spread so easily? This deep dive explores the psychology behind fitness misinformation, from fear-based marketing and algorithmic outrage to anecdotes, confirmation bias, and identity protection. It also examines evidence hierarchies, replication, survivorship bias, and a practical checklist for separating credible health claims from viral nonsense.
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36 snips
Sep 14, 2026 • 36min

AMA 6 - Weight Loss, Genetics, Muscle Confusion, Who To Trust, and More

A lively listener Q&A tackles training to failure, the myth of muscle confusion, muscle mass and longevity, and why tracking beats intuition during fat loss. It also explores ultra-processed foods, metabolic adaptation, trustworthy fitness advice, wearable recovery scores, genetics, and adapting workouts to life’s changing demands.
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76 snips
Aug 31, 2026 • 36min

Overrated/Underrated: Muscle Building Edition

Which muscle-building strategies deserve the hype? This evidence-based ranking tackles training intensity, failure, volume, rep ranges, range of motion, exercise variety, frequency, protein, carbs, calorie surpluses, nutrient timing, creatine, and testosterone boosters. Expect myth-busting on muscle confusion, the anabolic window, and the idea that more training always means more growth.
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19 snips
Aug 17, 2026 • 2h 21min

The Ketogenic Diet with Dr. Dominic D'Agostino

Dominic D'Agostino, a researcher and professor known for ketogenic diet and metabolic therapy work. He discusses ketone mechanisms, seizure protection, ketone esters, and potential therapeutic uses for dementia and cancer. Practical considerations, protein and micronutrient needs, and how keto compares for fat loss, performance, and long‑term adherence are also covered.
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82 snips
Aug 3, 2026 • 40min

Overrated/Underrated: Fat Loss Edition

A data-driven ranking of common fat-loss tactics, separating hype from what evidence supports. Topics include fasting, low-carb vs low-fat, whole foods, carb timing, cardio and resistance training, circuit classes, diet breaks, protein, meal timing, artificial sweeteners, regular weighing, GLP-1 drugs, and the truth about fat-burner supplements.
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57 snips
Jul 20, 2026 • 2h 1min

Sports Nutrition & Performance with Dr. Mike Ormsbee

Dr. Mike Ormsbee, Professor and Director at FSU’s Institute of Sports Science and Medicine, blends athletic roots with pragmatic research. He dives into resistance training versus endurance for fat metabolism. He explains pre-sleep protein, recovery, and sleep effects. He debates collagen, talks research limits and bias, and emphasizes practical, evidence-based approaches to performance.
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72 snips
Jul 6, 2026 • 1h 16min

Metabolic Adaptation

A clear breakdown of metabolic adaptation and why fat loss often slows down. Short explanations of how BMR, NEAT, exercise energy, and TEF change with dieting. A tour of hormonal shifts like leptin and ghrelin and brain responses that drive hunger. Discussion of adipose changes, rapid refeeding effects, and practical, research-backed strategies to limit these adaptations.
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34 snips
Jun 22, 2026 • 57min

AMA 05 - Creatine, Plant Protein, Collagen, Fiber, GLP1s and More

A rapid-fire Q and A on supplements, protein sources, cholesterol, weight-loss meds and more. Creatine forms, plant versus animal protein counting, and collagen’s limits get tackled. Safety questions on ashwagandha and fiber tips for health are covered. LDL particle debates and practical guidance on GLP-1 medications and preserving muscle during weight loss are discussed.

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