Dr. Charles Brenner, an expert on NAD metabolism and longevity supplements, joins the conversation to break down the science behind NAD and NMN. He explains how NAD coenzymes are crucial for energy metabolism and discusses their decline with age. The chat dives into the misconceptions surrounding these supplements and critiques popular longevity claims made by figures like Andrew Huberman and Peter Atiyah. Brenner emphasizes the importance of a healthy lifestyle over reliance on unproven treatments, making it clear that foundational health practices are essential.

Drs. Karl and Spencer chat with Dr. Fatima Cody Stanford all about obesity, genetics, and her appearance on 60 minutes.Does Dr. Sanford believe lifestyle doesn't matter for obesity?Find out by listening!Watch Dr. Stanford's 60 minute clip Join Dr. Spencer's Obesity Clinic

Drs. Karl and Spencer chat about the new Lancet Commission's report on Clinical Obesity along with the new study on high dosed Wegovy. Learn:How 7.2 mg of Wegovy (semaglutide) compares to 2.4 mgWhat the proposed definitions of clinical and preclinical obesity areClick here to join Dr. Spencer's new online clinic

This week, Alexandra Sowa, author of "The Ozempic Revolution," joins to discuss groundbreaking GLP-1 medications and their impact on weight management. She sheds light on why she wrote her book and shares crucial tips for those considering these treatments. The conversation also tackles the societal stigmas associated with obesity, revealing the psychological hurdles patients face. With laughter and insightful dialogue, they explore the evolution of obesity medicine and the importance of education in combating misinformation.

Delve into the intriguing concepts of microdosing GLP-1 receptor agonists and the latest results from a new weight loss drug. Discover the balance between ethical medication access and corporate practices in healthcare. Hear about the eccentric quest for longevity and the disparities in medication availability. Explore the implications of microdosing terzepatide on inflammation versus weight loss. Unpack the ethical concerns surrounding cosmetic weight loss medications and the importance of responsible pharmaceutical practices.

Dr. Lauren Colenso-Semple, a PhD researcher specializing in exercise and menstrual cycles, shares her expertise on how menstrual phases should influence workout plans. She discusses the impact of hormone fluctuations on resistance training and the need for customized approaches as women experience their cycles differently. Myths surrounding hormonal contraceptives are debunked, while the significance of strength training for women is emphasized. Dr. Colenso-Semple advocates for more tailored fitness regimens that consider these unique physiological changes.

The podcast dives into the results of the Surmount 5 trial, comparing Zepbound and Wegovy for weight loss. The discussion highlights the benefits of these medications, including cardiovascular effects and safety profiles. A fascinating study on GLP-1 medications revealing reduced alcohol consumption adds an intriguing angle. The risks of misusing compounded GLP-1s are also examined, drawing attention to patient safety and regulatory issues. Finally, there’s a lighthearted critique of societal attitudes towards obesity treatment and the role of big pharma.

Dr. Shivani Misra, a metabolic specialist physician researcher from the UK, dives deep into the complexities of diabetes classifications. She discusses the intricate types of diabetes, including monogenic forms, and the challenges in diagnosing lean individuals. The conversation addresses the usefulness of Continuous Glucose Monitors (CGMs) and the potential benefits of low-carb diets for certain patients. With insights on managing diabetes beyond lifestyle factors, Dr. Misra emphasizes the need for personalized treatment strategies.

Josh Umbehr, a physician and expert in direct primary care, shares fascinating insights on revolutionizing healthcare delivery. He highlights how cutting out middlemen can significantly reduce costs for lab tests and medications. The discussion dives into the inefficiencies of traditional insurance models, advocating for a more direct doctor-patient relationship. Umbehr emphasizes the benefits of simplified pricing and the need for innovative solutions to improve chronic disease management, making healthcare both affordable and effective.

Discover the latest three-year study on tirzepatide, revealing its impact on weight loss and the challenges of maintaining it long-term. Dive into the side effects like nausea and pancreatitis, but see how they taper off over time. Uncover the potential of semaglutide in easing knee pain for those with osteoarthritis. Enjoy some humorous political musings, imagining a 'buff doctor' running for office while blending health and society's perceptions. It's a mix of science, laughter, and insights into modern weight management!