Space Business Podcast

Mini-brains in space. Did you know that we can study something called brain organoids, effectively mini-brains, in the special conditions in space, on the International Space Station, and that such studies may help us with diseases like Alzheimers, Autism or Parkinsons? My guest this week is Prof. Alysson Muotri from the University of California San Diego. He and his team have flown such brain organoids to the ISS many times already. Don’t miss this episode on what I consider one of the most exciting intersections of space and biology, and ultimately a potential source of massive positive impact right here on Earth! 🕰️ Timestamps:  00:00 Intro 00:29 Alysson Muotri 02:12 Understanding Brain Organoids 03:49 Stem Cells and Brain Organoids 10:31 Accelerated Aging in Space 14:18 Challenges and Discoveries in Space Research 17:33 Applications and Future Research 26:43 Neurodegenerative Diseases 27:27 Brain Organoids in Computing 29:25 Ethical Considerations of Brain Organoids 31:32 Regenerative Medicine and Brain Organoids 34:39 Brain Evolution and Neanderthal Genes 39:21 Space Research and Future Prospects 43:58 Challenges and Opportunities in Space Biology 47:22 Science-Fiction   🔗 UCSD Sanford Integrated Space Stem Cell Orbital Research Center (ISSCOR) 🏠Website :  https://stemcells.ucsd.edu/centers/sanford-integrated-space-stem-cell-orbital-research-center/index.html   🔗 Follow us: 🏠Website : https://www.e2mc.space/ 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/

How can we make operating in space safe & sustainable for everyone? Given the risks we face up there, like space debris and adversarial actors. This is where a company like Slingshot Aerospace comes in with its sensors, data, and insights derived from that data. My guest this week is their CEO, Tim Solms. Enjoy! 🕰️ Timestamps:  00:00 Intro 01:44 Elevator Pitch 01:53 Founders and Mission of Slingshot Aerospace 03:28 Challenges in Space Operations 04:18 Situational Awareness in Space 05:41 Slingshot's Sensor Network and Data Collection 14:21 Data Sharing and International Collaboration 19:50 Autonomous Operations and Future Prospects 24:23 Avoiding Contact in Space 25:26 Understanding Space Traffic Management 25:46 Global Space Traffic Management 26:41 The Role of the Office of Space Commerce 30:28 Challenges of Space Debris 31:33 In-Orbit Refueling and Space Operations 35:40 Slingshot's Future 40:02 Tim's Background 42:48 Future of Commercial Space 44:22 Science Fiction   🔗 Slingshot Aerospace 🏠Website :  https://www.slingshot.space/   🔗 Follow us: 🏠Website : https://www.e2mc.space/ 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/    

Space & Biology – we have another episode on this exciting intersection of deep tech themes. My guest this week is Paul Kamoun from SpacePharma. He also organizes an entire conference on space bio, called “Health from Space” every year. We talk about what use cases he finds most exciting, and the opportunities and challenges on the road to scaling space biology into the next big thing. Enjoy! 🕰️ Timestamps:  00:00 Intro 00:17 Background on Paul Kamoun & SpacePharma 01:18 The Exciting World of Space Biology 04:37 Understanding the Role of Gravity in Biology 08:38 Applications and Use Cases in Space Biology 13:50 Challenges and Opportunities in Space Manufacturing 18:34 The Future of Space Life Sciences 37:15 Regulatory and Policy Considerations 40:51 Closing Thoughts and Science Fiction   🔗 Health from conference: 🏠Website : https://www.healthfromspace.com/en/   🔗 Follow us: 🏠Website : https://www.e2mc.space/ 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/  

Justin Stevens, founder and CEO of Overlap Holdings and a seasoned investor from Apollo Global Management, dives deep into the intricacies of space financing. He discusses why traditional investment methods may not support the space sector effectively. The conversation highlights the importance of balancing debt and equity in startup funding, the challenges of accessing government contracts, and emerging investment trends. Justin shares insights into the future of space ventures and the economic potential beyond Earth, blending finance with fascinating frontier technology.

My guest this week is Pierre Lionnet, Director of Research at Eurospace, who has followed the global space sector for over 30 years. We discuss a range of topics including e.g. SpaceX, the launch sector in general, and national space policies. Pierre is one of my favorite people to follow on space as he usually provides very frank and thought out opinions. I think this comes through in this episode - enjoy!   🕰️ Timestamps:  00:00 - Introduction  00:55 - Guest Introduction 01:34 - Day-to-Day Activities at Eurospace 03:15 - Challenges in the Space Sector 06:22 - SpaceX's Impact on the Space Industry 07:35 - Economic Contributions and Cost Structures 11:02 - Production and Market Segmentation in Space 21:44 - Institutional Programs vs. Commercial Ventures 27:40 - Starlink's Business Model and Future Prospects 35:12 - SpaceX's Dominance in Commercial Launch 35:56 - The Cost and Pricing of Space Launches 38:40 - Starship's Potential and Market Impact 40:51 - Challenges for New Market Entrants 43:25 - National Space Policies and Industrial Strategies 46:27 - Global Space Economy and Future Projections 55:16 - Advice for Emerging Space Nations 01:00:19 - The Future Structure of the Space Economy 01:05:13 - Science Fiction and Space 01:06:07 - Conclusion    📍 About the Guest: Pierre Lionnet is the Research and Managing Director at Eurospace, the trade organization of the European space industry). He labels himself a space economist, being an economist by training and being professionally involved in the analysis of space markets, space industry supply chains and space technology and innovation trends for the past 30 years   🔗 Connect with Pierre: 🤝 LinkedIn: https://www.linkedin.com/in/eurospacepierrelionnet/   🔗 Follow us: 🏠Website : https://www.e2mc.space/ 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/  

My guest this week is Sebastian Klaus, Co-Founder & CEO of Atmos Space Cargo, who discusses his company’s mission to unlock downmass logistics with an innovative and reusable space capsule, paving the way for in-space manufacturing, defense applications, and other applications. 🕰️ Timestamps:  00:00 - Introduction 00:59 - Elevator Pitch 02:07 - Importance of Returning Cargo from Space 04:24 - Challenges and Technologies in Space Re-entry 06:16 - Innovations in Heat Shield Technology 11:16 - Economic Impact and Reusability 13:12 - Mission Operations and Logistics 20:15 - Regulatory Considerations 22:33 - ATMOS Phoenix Capsule 23:36 - Impact of Starship on Space Logistics 25:13 - Space Stations and Free Flyers 27:22 - Market Segments in Space Logistics 30:35 - Defense Applications and Future Prospects 37:16 - Recent Test Flight and Future Plans 42:07 - Science-Fiction   📍 About the Guest: Sebastian Klaus holds a Master of Science in Aerospace Engineering with a focus on atmospheric re-entry and reusable rocket engines. He has more than a decade of leadership experience as a military officer, supplemented by business knowledge from an MBA program at ESB Business School Reutlingen. Sebastian has developed and submitted several patented technologies for entry and descent. With a commercial pilot license and unique knowledge about parachute systems, as well as passion for nature and spaceflight, he is determined to overcome existing and future challenges in life sciences research in space in order to benefit all of humanity. 🔗 https://atmos-space-cargo.com/   🔗 Follow us: 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC 🏠Website : https://www.e2mc.space/   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/  

My guest this week is Glen Martin, Co-Founder & CEO of Extraterrestrial Mining Company (XMC), discusses his company’s bold mission to mine Helium-3 on the Moon and its potential to revolutionize energy and tech on Earth.   🕰️ Timestamps:  00:00 - Introduction  01:36 - Elevator Pitch 03:42 - Understanding Helium-3 and Its Applications 11:59 - Tech Aspects of Lunar Mining 20:39 - Future Prospects and Initial Missions 23:31 - Energy Solutions for Lunar Operations 29:23 - Helium-3 Concentrations and Mining Challenges 32:09 - Lunar Data and Exploration Techniques 35:32 - Geopolitical Implications 40:33 - Transportation and Return Logistics 48:08 - Project Financing for Space Mining 51:28 - Personal Background and Career Path 56:14 Science Fiction   📍 About the Guest: Glen Martin, CEO of XMC, has over 30 years of experience in renewable energy and space infrastructure. Before founding XMC in 2023, he led companies like Hyox Inc., Infrastructure Energy, and Pod Generating Group, and co-founded ProtoStar Limited. He’s worked on projects spanning green hydrogen, solar PV, intelligent grids, and satellite systems. Early in his career, he contributed to the International Space Station at McDonnell Douglas. Glen holds a BTech in Aerospace Engineering from TMU and an MBA from USC.   🔗 Connect with Glen: 🤝 LinkedIn: https://www.linkedin.com/in/glen-martin-space-heavy-industrialist/   🔗 Follow us: 🏠Website : https://www.e2mc.space/ 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/

This episode kicks off a new series on in-space R&D and manufacturing, exploring its potential (e.g. for sectors like pharma and semiconductors), its current status, and its challenges, among other topics. At the end of this episode, Raphael highlights the recent launch of the Orbital Edge accelerator to support startups in this emerging sector.   Orbital Edge Accelerator: https://orbitaledge.techconnect.org/   🕰️ Timestamps:  00:00 - Introduction  02:23 - Why research and manufacture in Space? 10:28 - How to research and manufacture in Space, in practice? 22:35 - How can be build a thriving in-space R&D and manufacturing sector? 28:45 - Conclusion    🔗 Follow us: 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓https://www.edx.org/course/new-space-economy Space Business Newsletter 📬 https://spacebusiness.substack.com/

My guest this week is Adel Haddoud, Founder & CEO of Infinite Orbits, a French in-orbit servicing company. We discuss their technology, business model, and vision, as well as the broader market for satellite servicing and space sustainability. Enjoy! 🕰️ Timestamps:  00:00 - Introduction 01:04 - Elevator Pitch  03:30 - Origin Story 04:51 - Technological Innovations 07:35 - Core of the Company 09:15 - Computing Hardware in Space 12:47 - Market Segments and Competition 18:38 - Life Extension in Space 23:49 - Unit Economics  26:13 - Life Extension and Docking 30:22 - OrbitGuard and Defense  31:06 - European vs. U.S. Space Market Dynamics 33:10 - Technological Advances and Future Prospects 42:06 - The Future of Space Servicing 45:00 - Interesting Developments in the Industry 45:55 - Sci-Fi Favorites   📍 About the Guest: Adel Haddoud is the Founder & CEO of Infinite Orbits, a Toulouse-based space company pioneering in-orbit services like satellite inspection and life extension. In 2024, the company raised €12 million from private and public investors, following the successful 2023 test of its OrbitGuard1 nanosatellite—the world’s first geostationary nanosatellite. Founded in 2017, Infinite Orbits has developed an innovative space rendezvous solution using in-orbit image recognition. Adel previously had a career as an entrepreneur and manager, including a stint in Silicon Valley. 🔗 Connect with Adel: 🤝 LinkedIn: https://www.linkedin.com/in/adelhaddoud/   🔗 Follow us: 🏠Website : https://www.e2mc.space/ 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/  

Asteroid mining is making a comeback. It may sound futuristic, but some startups are betting on a viable and economic path to making it a reality and investors are taking notice. One of those companies is Karman+, and this week, I’m joined by its Co-Founder, Daynan Crull. Enjoy!   🕰️ Timestamps:  00:00 - Introduction 01:13 - Elevator Pitch 04:18 - Vision and Challenges of Asteroid Mining 06:07 - Recruitment and Team Building 07:44 - Origin Story and Motivation 12:35 - Market Timing and Investor Sentiment 19:49 - Technological and Logistical Challenges 26:12 - Geopolitical and Legal Considerations 32:11 - Mission Timeline and Milestones 36:53 - Economic Viability of Asteroid Mining 41:16 - Future Missions and Scaling Operations 45:19 - Interesting Developments in the Industry 46:15 - Sci-Fi Favorites   📍 About the Guest: Daynan Crull is the Co-Founder and Mission Architect at Karman+, leading efforts to mine Near-Earth Asteroids for sustainable energy and resources. Previously, he was a Senior Data Scientist at New Light Technologies and the World Bank. From 2018 to 2020, he held data science roles at GeoPhy. Before transitioning to tech, he served in strategy and policy roles at the NYC Mayor’s Office and the Department of Information Technology & Telecommunications. Earlier, he worked at Blue State Digital and the NYC Council. Crull holds an M.S. in Urban Informatics from NYU Tandon and a B.A. from DePauw University. 🔗 Connect with Daynan: 🤝 LinkedIn: https://www.linkedin.com/in/daynan/   🔗 Follow us: 🏠Website : https://www.e2mc.space/ 🤝🏻LinkedIn : https://www.linkedin.com/company/space-business-podcast/ 🌐Socials: https://linktr.ee/spacebusinesspodcast     🔗 Follow Raphael: 🔷LinkedIn -  https://www.linkedin.com/in/raphaelroettgen 🌐Instagram - https://instagram.com/raphael_space/  ◇  Twitter/X - https://x.com/RaphaelE2MC   To Learn more about Space & the Space Economy: "To Infinity" – Raphael’s Revised Introduction to the Space Economy This book provides an insightful look into the space economy, its current trends, and future opportunities. 📚 https://a.co/d/6jIQ2LO  edX/EPFL's Space Economy MOOC This course offers a detailed understanding of the New Space Economy, covering key concepts and market developments. 🎓 https://www.edx.org/course/new-space- Space Business Newsletter 📬 https://spacebusiness.substack.com/