Healthcare Unfiltered

In this lively debate pertaining to all things multiple myeloma, Chadi hosts three guests with varying positions and viewpoints: Vincent Rajkumar, MD, Mayo Clinic; Manni Mohyuddin, MD, Huntsman Cancer Institute; and Cindy Chmielewski (@myelomateacher), patient research advocate. The group discuss the burning unanswered questions in multiple myeloma research and treatment – including problems related to clinical trial funding and design, control arms and “bad” trials, global disparities and drug access, standard-of-care changes during the course of a trial, and many more intricate dilemmas impacting the multiple myeloma world today.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Katie Coleman, a software engineer, joins the show to share her inspiring story of being diagnosed with a rare stage 4 kidney cancer at the end of 2020 and her journey through survivorship to the present day. Katie highlights the anxiety and guilt she experienced when moving through urgent care and the ER during the height of the pandemic, the struggles of not having family allowed in the room during her visits with oncologists or visits at home, the occurrences that led to eventual surgical removal, and what led to the decision to share her story on social media. Katie also built herself an app to keep track of her own medical records and made a career change to further build software to help other patients. You won’t want to miss this truly inspiring, incredible story.View Katie’s Youtube channel for more on her experiences.https://www.youtube.com/channel/UCcf5yVgHvI8-__g0RHjfrTwCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Ralph Weichselbaum, MD, the Daniel K. Ludwig Distinguished Service Professor of Radiation and Cellular Oncology at the University of Chicago, is the guest of honor on today’s show focusing on radiation oncology as a discipline: the changes that have occurred over the years, the state of the field today, and how the field projects over the next few years. Dr. Weichselbaum highlights the malignancies that are poised for improvements in radiation outcomes in the coming years, how little attention is paid to radiation oncology in medical school, the potential of proton therapy and the need for prospective randomized controlled trials in some diseases, and a Lancet Oncology paper he reacted strongly to on Twitter.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts Lars Andersen, MD, MPH, PhD, DMSc, Aarhus University Hospital (Denmark), to discuss an interesting, relatively unknown concept he recently explored in JAMA Guide to Statistics and Methods. Dr. Andersen introduces us to “collider bias” in research design and statistical analysis. He utilizes a few common examples to illustrate how collider bias can affect our interpretation of data, how it differs from confounding and information bias, and rates the quality of COVID-19 research with relation to collider bias. This is an important discussion that will alter how you assess the validity of data and results of published research.View Dr. Andersen’s paper “Collider Bias.”https://jamanetwork.com/journals/jama/fullarticle/2790247Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Amer Zeidan, MBBS (@Dr_AmerZeidan), MHS, associate professor of medicine, Yale University School of Medicine, joins the show to cover the latest exciting updates in the treatment landscapes for acute myeloid leukemia and myelodysplasia. The duo discuss the etiology of both malignancies, the intricacies of defining and diagnosing MDS, how patients become classified as either lower-risk or higher-risk MDS and the survival rates of both, concerns and consequences with iron overload during blood transfusions, and how transplant procedures have become safer for older patients. They then highlight the hot topics in MDS and AML as covered at the most recent ASH annual meeting.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

A familiar animated, jovial, Twitter-famed hematologist makes his return to the show to break down all of the most impactful hematology research of the past year, including what’s moving the needle in the CAR-T, DLBCL, non-Hodgkin lymphomas, Hodgkin lymphoma, AML, transplant, and multiple myeloma spaces. Who could the guest of honor be? Tune in to find out.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi’s guest Kashyap Patel (@KashyappatelMd), MD, president of the Community Oncology Alliance (COA), joins the show to give an update on the current initiatives and state of COA and community oncology as a whole. He chronicles his journey to becoming a medical oncologist at a small community center outside of Charlotte (SC) and how he became aware of the pain points of community oncology in the U.S. The conversation moved into the history and initial aim of COA to help community practices prepare to work with and have an identity when facing policymakers, how COA membership dues are put to use, the top five problems facing community oncology today, and why many community practices feel compelled to sell to large health systems. Dr. Patel also shares his vision as the president of COA and what he hopes to accomplish before his term ends.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Samarth Kulkarni, PhD, CEO of CRISPR Therapeutics, joins the show to chronicle his journey to CRISPR Therapeutics and to break down the ins-and-outs of the technology. He begins by sharing the evolution of CRISPR as a “molecular barcode” and its first viable indication; how he “bets” the technology will have a major footprint in the cancer, diabetes, and cardiovascular disease treatment landscape; shares strategies for shortening the potential time to market for some of the therapies; explains how AI is used in his line of work; and a variety of other topics.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Recurring guest Vincent Rajkumar (@VincentRK), MD, Mayo Clinic, provides his input on the complexities of randomized controlled trials. The conversation covers the ability of fellowship programs to train fellows in the nuances of clinical trials, how funding is divvied up for different kinds of trials, how trial design is often influenced by expected time for the new drug to get to the market, when the risk is worth taking with the accelerated approval pathway, how to reconcile study designs when studies with similar control arms are published throughout the world, and a whole lot more.Read Dr. Rajkumar’s spotlight piece in The Lancet.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)61801-1/fulltextCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi shifts gears this week to sit down with a renowned business leader: Samer Saab, founder and CEO of the experience management solution company Explorance. Samer sheds light on the challenges of starting and running a successful business, especially during a once-in-a-century pandemic, and the services Explorance offers. The Great Resignation, surveys given to healthcare workers, burnout, immigrant struggles, transparency and flexibility with employees, balancing personal lives with business lives as the leader of a company, lessons in leadership, business values, and a whole host of other topics are covered in this wide-ranging and inspiring interview.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA