Healthcare Unfiltered

Hosted by Ralph Weichselbaum, MD, Chair of the Department of Radiation and Cellular Oncology, University of Chicago, this episode tackles the burgeoning world of radiopharmaceuticals and features two radiation oncologists: Jeff Michalski, MD, MBA, Washington University in St. Louis and president of ASTRO, and Freddy Escorcia, MD, PhD, National Cancer Institute and National Institutes of Health. They kick it off by giving background context on isotope therapy and the current data for these therapies in different malignancies, including an update into peptides and SBRT; provide commentary on how randomized controlled trials account for the complexities of radiopharmaceuticals in their design (especially pertaining to selection criteria and dosage); and share how a radiation department is structured and staffed to account for all patient needs, including a push for a novel patient-centered approach that involves the nuclear medicine department.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Drs. Ross Levine, David Steensma, and a surprise recurring guest form a roundtable on today’s show to discuss making the career choice of a non-PhD lab-based scientist and what that entails on a day-to-day basis, how mentoring individuals in other labs is a rewarding and continuous process, what makes a good mentor, managing and securing grant funding for lab research (including the secrets of writing effective grants), making the transition from the clinic to industry and the day-to-day expectations in this environment, and misconceptions of the intentions and cultures of pharmaceutical companies. They wrap up the discussion with a commentary on the overabundance of medical meetings and how they are managing their conference travel schedules against their COVID wariness.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Jarushka Naidoo, MBBCH, MD, Chair of the Thoracic Oncology Division, Beaumont RCSI Cancer Centre (Dublin, Ireland), and Stephen Liu, MD, Director of Thoracic Oncology and Director of Developmental Therapeutics, Lombardi Comprehensive Cancer Center of Georgetown University, join the show to preview all of the important and exciting advancements in thoracic oncology leading up to the IASLC 2022 World Conference on Lung Cancer. The trio cover early-stage lung cancer, pathologic response as a surrogate endpoint for new clinical trials, promising new agents in development and testing, sequencing with immunotherapy, updates in data and targeted therapy for EGFR mutations, and a round-up of other studies highlighting different disease histologies.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts Dr. Neal Shore, a urologic oncologist who became heavily involved in GU oncology research – including trials that incorporate systemic chemotherapy. Dr. Shore has a unique practice where he and his staff deliver chemotherapy when appropriate. Chadi was intrigued by this setting as medical oncologists are the ones customarily delivering chemotherapy, and invited him to the show to share how this all started, its pros and cons, and the impact on patients.Dr. Shore explains how the field has seen drastic changes since the early 1990’s, why he decided to spearhead bringing clinical research into his community clinic, and how his clinic is staffed and structured to support a functioning and successful research hub. Then, the discussion pivots to his recently published clinical trial, ENACT, and the controversy surrounding use of enzalutamide monotherapy in low- or intermediate-risk prostate cancer. There’s been so much controversy and backlash about the ENACT trial that Chadi had to ask him about it and his reaction to what happened when the article was published.View Dr. Shore’s recently published ENACT study in JAMA Oncology. https://jamanetwork.com/journals/jamaoncology/fullarticle/2793567Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Returning guests Sanam Loghavi, MD, hematopathologist and molecular pathologist, University of Texas MD Anderson Center, and Aaron Goodman, MD, hematologist, University of California San Diego, break down the latest classification system updates in leukemia. They begin by explaining what triggers a new classification and why it is needed, how soon clinicians should adopt it, and the relationship as well as differences between the ICC and WHO classification systems. Then, the experts go into the details of the changes that have been made to AML and MDS diagnoses and how these are likely to impact clinical trials, among other important points.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

On this special episode, Chadi hosts three phenomenal physicians to help us better understand the complexity of designing and executing clinical trials. Hira Mian, MD, faculty of health sciences, McMaster University (Canada), and Murali Janakiram, MD, MS, assistant professor, City of Hope, both faced and continue to face challenges in bringing their clinical trial ideas to light. Saad Usmani, MD, MBA, FACP, chief of myeloma service, Memorial Sloan Kettering Cancer Center, joins as a senior investigator to shed light on the journey and to advise both junior faculty on what can be done next. The group reacts to trial ideas they’ve each had and continue to funding roadblocks. They consider how long down the road researchers should look when formulating a clinical trial design, how limited funding availability figures to be a lasting barrier for many important study ideas, how junior faculty members are vying for such funding to get published research under their belt and earn promotions, and so many more intricacies involved in the clinical trial landscape. This is a perfect episode for anyone interested in clinical trials and wanting to understand the role of a clinician investigator.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Joining Chadi on today’s show is Donald Harvey, PharmD, BCOP, FCCP, FHOPA, Winship Cancer Institute of Emory University. Dr. Harvey shares available career paths and how the pharmacist role has evolved over the years, how pharmacists continue to stay involved with patients after discharge, strategies he uses to help cancer patients adhere to oral oncolytics, and his “Call to Action” to improve such adherence – as co-planned by the FDA and ASCO and published in Journal of Clinical Oncology. The discussion is very detailed and enlightening; you won’t want to miss it!View Dr. Harvey’s publication “Call to Action for Improving Oral Anticancer Agent Adherence.”https://ascopubs.org/doi/10.1200/JCO.21.02529Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Christina Arnold, MD, gastrointestinal pathologist, University of Colorado, is today’s guest of honor discussing her unconventional career change to a full-time professional “life coach.” Dr. Arnold explains what inspired her to make this change, differentiates a life coach from a psychotherapist and how people should know which professional they need to see, reminds us how mental health is still under-resourced and forgotten among healthcare workers, shares her decision process for choosing a life coaching school and how long school took to complete, discloses typical payment and hours associated with the position, and a host of other discussion points.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Lee Shapiro, co-founder and managing partner at 7wireVentures, joins the show to discuss his unique journey through healthcare, entrepreneurship, and more. He begins by addressing broken business processes in healthcare as part of his early investment strategy, what he looks for in potential investment opportunities, how he forecasts investment in health technology in the coming years, past investment regrets (with a couple of specific company examples), his thoughts on PBMs, experiences taking his company public, and many more discussion points.Read more about Lee Shapiro.https://www.7wireventures.com/team/lee-shapiro/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts recurring guest Priya Sampathkumar (@PSampathkumarMD), MD, infectious disease specialist and hospital epidemiologist, Mayo Clinic, to provide the infectious disease profile of Mokeypox – the latest virus that is spreading globally and making its rounds in the media over the past few weeks. Dr. Sampathkumar highlights the virus’ symptom profile, differentiates it from Smallpox, explains the origins of infection in the US, shares theories for why the infection rate is increasing worldwide, speculates on whether it will develop into a pandemic, and covers all of the other important questions.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA