Healthcare Unfiltered

In this pivot episode, James Winterman, Vice President of Scientific Marketing at Caris Life Sciences, joins Chadi as a citizen of England to discuss and reflect on the passing of the late Queen Elizabeth II. He begins with a condensed history lesson of the United Kingdom, how the healthcare system differs slightly across the UK and how it compares to that of the US, and where government power rests. Then, he delves into the royal family and their position in all of this. What social and political roles do individuals in the royal family have? How and why does the royal family bring the people of England together? James answers these questions and more, along with a detailed explanation of how the Queen has had a more profound impact on his life than he had known before her passing.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Stacie Dusetzina, PhD, Professor of Health Policy, Ingram Professor of Cancer Research, Vanderbilt University Medical Center, makes her long-awaited return to the show to cover all things related to pharmacy benefit managers. Stacie talks about the good, the bad, and the ugly, starting with the history of the PBMs and how they grew within the healthcare industry. What exactly is the role of the PBMs and why do they exist? Have they helped in reducing cost of care, and if not, why? Why are they heavily criticized? Stacie, as always, articulates the facts and separates the signal from noise.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Tiffany McConathy, an oncology nurse practitioner in Arkansas, tells the sombering story of her infant daughter’s battle with pediatric brain and spinal cancer. She details Nora’s course of events, including the long pathology and diagnosis journey, the decision to move forward with treatment, and the months of good responses that followed prior to her passing. Tiffany also shares how Nora’s COVID-19 diagnosis during treatment pushed back her transplantation and eventual autopsy, just 9 days before her passing. This deeply saddening discussion will inspire you to think differently about pediatric cancers, just as the experience has inspired Tiffany to create the non-profit organization “Princess Nora’s Warrior Foundation.”Read about and donate to this foundation.https://noraswarriors.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Kyle Kiser, CEO of Arrive Health, joins the show to highlight his company’s unique approach to lowering costs of prescription drugs for patients in the US. He explains how physicians often make changes to their prescription recommendations based on Arrive Health’s presence as an “invisible component within the EMR,” how they aggregate data to generate clinical alternatives and relevant alternatives to payer preferences, how they maneuver around prior authorizations, the need (or lack thereof) of intermediaries like PBMs, and much more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts a duo of Canadiens to discuss quality of life and patient-reported outcomes in clinical trials: Christopher Booth, MD, and Michael Brundage, MSc, FRCPC, MD, both of Queen's University. They begin by pontificating on whether quality of life is a “must” endpoint in designing interventional clinical trials today, the timeline of how “PROs” came to be a term and an important component of clinical trials, how PRO measures should differ across disease types and trials, and how PROs should be approached from an organizational and operational standpoint. Then, they discuss and use examples to illustrate how practical it is for providers to regularly measure quality of life and PROs, how payers should be approached for discussion on PRO measures, whether toxicity of therapies are underestimated by providers, and a whole lot more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Mike Rucker, PhD, a behavioral scientist and organizational psychologist, joins the show to discuss his writing and publishing of the book “The Fun Habit: How the Pursuit of Joy and Wonder Can Change Your Life.” Dr. Rucker explains how you can build having fun into an “actionable and effortless habit” and simultaneously reduce burnout. He shares why Americans have a difficult time enjoying themselves outside of work, what it means to “stop chasing happiness and start having fun,” what kind of societal reset is needed to change the work culture mindset in the US to lead to more productivity, how to “expand your fun file,” and why friendship is the “glue” to good mental hygiene.Read more about Mike Rucker.https://michaelrucker.com/bio/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

How do you design clinical trials in the era of precision oncology? Are prospective randomized controlled trials necessary anymore? Drs. Ray Kurzrock, Vivek Subbiah, and Christopher Booth drop the gloves and debate these questions - beginning with the definition of “precision oncology,” what phase the trials should be when initially designing, and whether accelerated approval and surrogate endpoints are truly helping patients in the precision oncology era. The group also analyzes specific examples of approved drugs and whether randomized controlled trials were and would have been good ideas prior to approval.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In a change-of-pace episode, Chadi has the tables turned on him as he is interviewed by two supporters and reviewers of his new book “Toxic Exposure: The True Story behind the Monsanto Trials and the Search for Justice.” Kelly Ryerson, MBA, GlyphosateGirl.com, and Mikkael Sekeres, author of “Drugs and the FDA: Safety, Efficacy, and the Public's Trust” and “When Blood Breaks Down: Life Lessons from Leukemia,” ask Chadi to comment on why he was chosen as an expert witness, how glyphosate causes cancer and how much exposure is needed to cause lymphoma, why Roundup is able to stay on the market to this day, and what it was like to take the stand and answer questions from the Monsanto lawyers, among so much more.Order your copy of “Toxic Exposure” today.https://www.amazon.com/Toxic-Exposure-behind-Monsanto-Justice/dp/1421445352Check out Kelly’s blog-turned-website “Glyphosate Facts.”https://glyphosatefacts.com/

In the latest book review, Chadi hosts the authors of the successful expose of his former colleague in “Taking On Big Pharma: Dr. Charles Bennett's Battle.” Julius Getman and Terri LeClercq share how they met Dr. Bennett on a cruise and became interested in his story about his massive achievements and legal charges against him - mishandling government grant money and violating the False Claims Act. They begin with their reasons for believing that the case against Dr. Bennett was baseless and unfounded, what the actual accusations were, and how he ended up facing off against the pharmaceutical and academic worlds.Read more about “Taking On Big Pharma: Dr. Charles Bennett's Battle.”https://www.amazon.com/Taking-Big-Pharma-Bennetts-Childrens-ebook/dp/B0BHTP6P8GCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

A story about adverse reactions, the FDA, the FBI, and patients - Linda Martin, a healthcare executive, shares with Chadi a riveting dialogue about the events in her life that have transpired since she got sick and started taking a standard prescribed antibiotic. Linda tells the story of when and why she was prescribed the antibiotic, how it made her feel worse than before, and how she found similar stories of bad reactions to this drug online. Then, she explains the series of events that led to the stepping-down of the commissioner of the FDA, the FBI’s involvement into investigating drug stock conflicts within the FDA, the stalling of any legal action coming to fruition that may be linked to multiple U.S. presidents, and the suspicious death of the journalist she had been working with to expose the cover-up.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA