The Kris Gethin Podcast

Most people using GLP agonists are doing it wrong. Semaglutide? Tirzepatide? They’re not magic pills, they’re misunderstood tools. In this episode, I answer your most common questions and break down what these drugs actually do inside the body. We get into the real science: how GLPs suppress appetite, slow digestion, improve insulin sensitivity, and change energy balance. I explain the difference between GLP‑1, dual agonists like tirzepatide (GLP + GIP), and next-gen options like retatrutide (GLP + GIP + glucagon). You’ll learn why fat loss happens, why muscle loss is a major risk, and how to train, eat, and supplement so you stay jacked, not soft. We cover the rebound effect when you stop, what stacks are worth considering, and how to avoid wrecking your gut or your gains in the process. If you're serious about fat loss, muscle retention, and metabolic health, this is mandatory listening. These compounds can change your trajectory. Or wreck it. The difference is your discipline. What's Discussed: (00:01) Are GLP Drugs Just Fancy Appetite Suppressants? (02:57) The Real Reason You're Losing Muscle on Semaglutide (05:23) What Happens When You Come Off? The Rebound Most Miss (06:59) Using GLPs as an Athlete? Here's What Can Go Sideways (13:06) How to Actually Maximize GLPs Without Wrecking Your Gains Thank you to our sponsors: NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/  My Go-To for Muscle Building: Isolate + CreGaatine + Dileucine from Unmatched Supplements https://www.unmatchedsupps.com/collections/muscle-building My Go-To for Gut Health: Glutamine and Imuno-IGG from Unmatched Supplements: https://www.unmatchedsupps.com/collections/digestion-gut-health    Find more from Kris: Website: https://www.krisgethin.com/  Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin    

Most NAD+ supplements are fluff. NMN? NR? They’re precursors, half the story. In this episode, I break down why NAD3 isn’t just another molecule, it’s the master key for energy, recovery, and longevity. We get into the real science: how NAD+ fuels your mitochondria, repairs DNA, activates sirtuins, and slows aging at the cellular level. I explain why levels crash after 40, how stress, toxins, and training hammer your reserves, and why NMN/NR often fail thanks to CD38 and PARP overactivity. You’ll learn why NAD3 bypasses the weak links, how it stacks with spermidine, glutathione, and autophagy activators, and why Regen NAD is the one I actually use daily, because it works. Forget the hype. This is metabolic firepower that hits. If you’re overtrained, under-recovered, or want to stay biologically younger for longer: listen in. What's Discussed: [00:30] – What Is NAD+ and Why It’s Non-Negotiable [03:30] – Why Your NAD Levels Plummet After 40 [07:15] – NMN & NR: Overhyped Precursors That Don’t Deliver [09:30] – NAD3: The Smarter, More Effective Upgrade [11:00] – My Daily NAD Protocol (and Why IVs Suck)   Thank You for Our Sponsors: NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/  Peptide Flask - Get your here and use KRIS10 is the code for 10% off.  My Go-To for Gut Health: Glutamine and Imuno-IGG from Unmatched Supplements: https://www.unmatchedsupps.com/collections/digestion-gut-health Find more from Kris: Website: https://www.krisgethin.com/ Website:https://www.unmatchedsupps.com Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin 2 Shred: https://www.unmatchedsupps.com/products/2shred 

Most guys fall apart with age. Excuses pile up. Strength fades. But Mike Ryan proves you can get stronger every decade. At nearly 60, he’s outlifting men half his age, and he’s been doing it while training Hollywood’s biggest names like Dwayne “The Rock” Johnson . In this episode, we break down what actually drives longevity in fitness. Mindset over motivation. Why recovery, hydration, and sleep matter more than the latest trend. And why your environment will dictate your results more than any program. Mike gets real about TRT and peptides, the role of cheat days, and what decades at Gold’s Gym Venice have taught him about strength, discipline, and staying relevant. We also tackle overrated vs. underrated exercises, celebrity training under pressure, and how to avoid the social media nonsense that’s making lifters weaker. Mike Ryan is a Gold’s Gym Venice legend who’s trained top celebrities and athletes, including Dwayne “The Rock” Johnson. At nearly 60, he’s still pushing massive weight and proving that longevity comes from discipline, mindset, and consistency. What's Discussed: (00:00) From Gold’s Gym to Celebrity Training and Longevity (10:31) Evolution of the Fitness Industry and Staying Relevant (16:56) Training Secrets Recovery Habits and Performance Enhancers (27:05) Pop Culture Conversations and Personal Insights (33:47) The Shocking Cyberbullying Documentary That Left Us Speechless Thank you to our sponsors:  NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    Find more from Kris: Website: https://www.krisgethin.com/  Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin    2 Shred: https://www.unmatchedsupps.com/products/2shred     Find more from Mike Ryan: Instagram: @mike_ryan_celebritytrainer   

“Destroyed by the gut.” “Zero absorption.” “Only injectables work.” This is BS. In this episode, I break down why oral peptides aren’t just working, they’re evolving. I cover the science, the delivery tech, and the results I’ve lived through: cartilage regrowth, hormonal optimization, cognitive firepower. You’ll learn how short-chain peptides bypass gut breakdown via PEPT1. Why nano-carriers, mucoadhesive polymers, and smart pH triggers are rewriting absorption. And why anyone still parroting the “oral doesn’t work” myth is stuck in 2005. I show you my travel peptide stack, how I keep everything cold, and why oral bioregulators like Sigma, Testolutin, and Biomind are now staples in my rotation. This isn’t hype. This is recovery, immunity, and performance…elevated. What's Discussed: (00:06) Oral Peptides: Why the “Destroyed by the Gut” Claim is BS (02:42) My Travel Stack: Fridge, Injectables, and Immune Armor (04:39) Brain on Fire: The Peptides That Keep You Sharp (08:19) Biohacking Absorption: How Oral Peptides Actually Work (16:54) What Makes Next-Level Recovery My Go-To for Gut Health: Glutamine and Imuno-IGG from Unmatched Supplements: https://www.unmatchedsupps.com/collections/digestion-gut-health Find more from Kris: Website: https://www.krisgethin.com/ Website:https://www.unmatchedsupps.com Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin 2 Shred: https://www.unmatchedsupps.com/products/2shred    

​​You take creatine. You think it’s working. But if you’re bloated, cramping, or seeing zero gains, you’re not absorbing it right. Here’s the truth: monohydrate saturates one transport pathway. Once that’s full, you're done. Up to 30% of users feel nothing. Add GI issues and brain access problems, and you're building strength on a weak foundation. In this episode, I break down CreGAAtine, a next-gen formula with creatine monohydrate, GAA, and B vitamins. It hits four pathways, not one. That means better muscle saturation, stronger brain uptake, and zero bloating. I cover absorption, ATP regeneration, neuroprotection, and why this crushes the “non-responder” excuse. You get more power, more cognitive resilience, and faster recovery, without these side effects. I show you how I take it, why it works year-round, and how it fits into a performance-first lifestyle. Listen in. Then upgrade your creatine. Your strength, brain, and gut will thank you. What's Discussed: (00:01) Evolution of Creatine (01:22) Limitations of Monohydrate (04:13) Brain Absorption & Non-Responders (05:26) What Makes CreGAAtine Different (11:42) Benefits of Creatine Supplementation Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    My Go-To Creatine: CreGAAtine from Unmatched Supplements: https://www.unmatchedsupps.com/cregaatine-capsules Find more from Kris: Website: https://www.krisgethin.com/  Instagram: https://www.instagram.com/krisgethin/  Youtube: https://www.youtube.com/krisgethin   2 Shred: https://www.unmatchedsupps.com/products/2shred   

My Go-To Protein: UK Pasture-Raised Whey Isolate from Unmatched Supplements SHOP HERE: (BOGO 50% OFF SALE HAPPENING NOW): https://www.vitaminshoppe.com/p/isolate-grass-fed-whey-protein-rich-chocolate-2-lb-powder/unm-14114 You check the label. It says “grass-fed.” You think you’re getting the cleanest, most nutrient-rich protein possible. But here’s the truth: in the U.S., that label can mean almost nothing. Loopholes, grain finishing, inconsistent nutrient profiles, even hidden contaminants. And if you’re using that protein daily? You’re building your results on a shaky foundation. In this episode, I break down the real difference between UK/Irish pasture-raised whey isolate and most U.S. “grass-fed” protein. You’ll learn why sourcing, animal welfare, and processing methods matter for muscle growth, fat loss, recovery, and long-term health. We’ll talk nutrient density, bioactive fractions, contamination risks, sweetener choices, and how to spot marketing tricks designed to make cheap protein look premium. I’ll show you exactly what I use, why I use it, and how to make sure your protein works with your health, not against it. No fillers. No hype. Just facts you can use to choose better, recover faster, and perform longer. Listen in. Then upgrade your protein. What's Discussed: 00:01 – Why “grass-fed” on the label might not mean what you think 03:01 – The hidden factor that makes UK whey stand out 10:44 – The sweetener choice that could sabotage your results   My Go-To Protein: UK Pasture-Raised Whey Isolate from Unmatched Supplements SHOP HERE: (BOGO 50% OFF SALE HAPPENING NOW): https://www.vitaminshoppe.com/p/isolate-grass-fed-whey-protein-rich-chocolate-2-lb-powder/unm-14114 Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    Find more from Kris: Website: https://www.krisgethin.com/  Instagram: https://www.instagram.com/krisgethin/  Youtube: https://www.youtube.com/krisgethin   2 Shred: https://www.unmatchedsupps.com/products/2shred

You’ve been told you can’t have both. That you need to choose between getting lean or staying muscular. That’s BS and in this episode, I break down the exact strategies I use with high-performance clients around the world to help them burn fat without sacrificing size, strength, or muscle mass. You’ll learn how to leverage high-protein intake, amino acid timing, heat and cold therapy, cutting-edge peptides, fat-loss supplements, and deep sleep optimization, all backed by science and proven in practice. This is about performing at your peak, recovering faster, and protecting your hard-earned muscle while cutting down. No fluff. No shortcuts. Just precision protocols that get real results. Listen in, and upgrade your cut. What's Discussed: 00:26 – Burn Fat Without Shrinking: The Real Strategy 02:33 – Why High Protein Protects Muscle in a Cut 04:41 – How to Stay Anabolic During Fasted Cardio 06:08 – Use Sauna + Ice to Trigger Fat Loss and Recovery 13:36 – Poor Sleep Is Killing Your Gains—Here’s Why Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/ Find more from Kris: Website: https://www.krisgethin.com/  Instagram: https://www.instagram.com/krisgethin/  Youtube: https://www.youtube.com/krisgethin 2 Shred: https://www.unmatchedsupps.com/products/2shred   

You’ve followed every program. Taken every “science-backed” supplement. Tracked your sleep, steps, macros, and macros again. But results? Still inconsistent. Still frustrating. Still not reflecting the effort. That’s because you’re using generic tools for a highly specific machine, your body. In this episode, I walk you through the real game-changer: data-driven personalization. DNA testing. You’ll learn how to stop wasting time on plans that weren’t made for you, and start building a system based on your unique biology.  I’ll share the tools I use with VIP+ clients and myself to optimize recovery, cut fat, gain muscle, and extend healthspan well past 50. This isn’t optional anymore. If you want elite results, you need elite intel. No fluff. No hype. Just hard data and harder action. Listen in. Then upgrade everything. What's Discussed: 01:20 – Why cookie-cutter diets and generic plans are dead 03:55 – The real power of DNA: what your genes say about your gains 06:50 – How CGMs expose “healthy” foods that sabotage your energy 10:30 – Using HRV, blood work, and wearables to decide when to push or pull back 12:40 – Client case studies: stress, stubborn fat, and reversing biological age Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/  Find more from Kris: Website: https://www.krisgethin.com/  Instagram: https://www.instagram.com/krisgethin/  Youtube: https://www.youtube.com/krisgethin  2 Shred: https://www.unmatchedsupps.com/products/2shred   

You train hard. You track every damn macro. You’re doing the double cardio grind. But your body still looks soft, flat, or watery. Something’s off. In this episode, I break down 11 reasons your physique isn’t changing—even though you’re doing “everything right.” Trash protein quality. Chronic inflammation. Hormones out of whack. Training without progression. Stress jacking your cortisol through the roof. This isn’t motivational fluff. It’s physiological fact. You don’t rise to the level of your motivation. You fall to the level of your systems. Fix what’s broken. Apply what works. Listen in and level up. What’s discussed: (00:05) You’re Doing Everything Right—So Why Do You Still Look Soft? (02:18) Hitting Your Protein Target? Doesn’t Mean You’re Building Muscle (05:13) Starving Yourself Shredded? Here’s Why That Backfires (10:06) Low Libido. Brain Fog. Fat Gain. Your Hormones Are Screaming (16:01) Still Not Lean? Cold, Sleep, and Stress Might Be the Missing Link Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    Find more from Kris: Website: https://www.krisgethin.com/   Instagram: https://www.instagram.com/krisgethin/   Youtube: https://www.youtube.com/krisgethin   2 Shred: https://www.unmatchedsupps.com/products/2shred   

Is GLP-3s the Next Evolution in Peptides? Here’s What You’re Not Hearing Everyone’s obsessed with GLP-1s like GLP-1. But what if there’s a better option with more benefits, fewer side effects, and real potential for body recomposition, brain health, and gut repair? It’s called GLP-3 peptides, also known as Retatrutide, and most people haven’t even heard of it yet. In this episode, I break down why GLP-1s aren’t the miracle drugs people think they are. They suppress appetite, yes, but at the cost of muscle mass, nutrient absorption, and long-term metabolic health. GLP-3s work differently. It improves gut integrity, boosts BDNF for brain performance, enhances metabolic flexibility, and reduces inflammation at the root. I also walk through how I use GLP-3s in client protocols, from microdosing to blood work analysis, and how it fits into a serious longevity strategy. If you care about more than just weight loss, this is the peptide you need to understand. Listen to the full breakdown. This one matters. We Also Discuss: (00:04) Why GLP-3s are the peptide nobody’s talking about, yet (03:52) What is GLP-3s and how it differs from GLP-1 (07:22) Gut health and healing leaky gut with GLP-3s (10:46) Brain health, BDNF, and cognitive benefits (20:35) GLP-3s for longevity, inflammation, and full-body optimization (24:00) Final thoughts, client protocols, and how to get started with GLP-3s Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    Find more from Kris: Website: https://www.krisgethin.com/   Instagram: https://www.instagram.com/krisgethin/   Youtube: https://www.youtube.com/krisgethin   2 Shred: https://www.unmatchedsupps.com/products/2shred