The Optispan Podcast with Matt Kaeberlein

In this engaging discussion, board-certified psychiatrist Jon Berner delves into the transformative potential of ketamine and rapamycin in treating severe depression and chronic pain. He explains how these treatments impact microglia, facilitating a shift from inflammation to repair. Listeners will find intriguing insights on case studies, regulatory reforms, and the complexity of mast cell disorders. Jon also sheds light on the therapeutic possibilities for addiction and the importance of innovative, individualized approaches in mental health care.

Discover the potential of GLP-1 agonists beyond mere weight loss, as they may play a role in delaying biological aging. Delve into the complex relationship between health improvements and aging processes. Explore how these medications could extend lifespan and healthspan, while examining the risks associated with caloric restriction. Learn about the importance of lifestyle changes alongside GLP-1 agonists, including nutrition and resistance training, to maximize their benefits and ensure better metabolic health.

Subscribe to our channel: https://www.youtube.com/@optispan Check out the New York Times article: https://www.nytimes.com/2024/09/24/well/live/rapamycin-aging-longevity-benefits-risks.html Related episodes: “Zombie” Senescent cells may play HUGE role in LIVING LONGER, Here's How: https://www.youtube.com/watch?v=-H6cDIl6pgo NEW PEARL Trial Results: Your Questions Answered on Aging with Rapamycin for Longevity: https://www.youtube.com/watch?v=JUAXqSSnXzo Matt and Nick discuss a recent New York Times article about rapamycin and its potential as a life-extending and/or anti-aging drug (the article quotes Matt). Matt answers various questions from Nick related to the article about topics including whether one should "feel something" when taking rapamycin, precautions to take when using the drug off-label, and what we know about rapamycin and fertility, cholesterol levels, and neurodegenerative disease. Matt also discusses likely reasons behind the mixed results observed thus far in human clinical trials of rapamycin, and emphasizes the need for well-powered, randomized clinical trials to better profile and understand the true efficacy of rapamycin in humans. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

The hosts dive into the caffeine timing debate, questioning whether you should wait before sipping that morning coffee. They share personal caffeine habits and discuss how individual sensitivity shapes experiences. A 2005 study on caffeine's effects on cortisol levels is explored, revealing its complex relationship with sleep. They challenge common myths about coffee consumption timing, pushing for evidence-based discussions instead. This lively conversation uncovers the nuances of our favorite morning ritual!

A recent study suggests metformin may slow biological aging in male primates, sparking intriguing discussions. The hosts critically analyze the research methodology and the importance of thorough data presentation. They delve into the evolving views on metformin’s role in longevity and emphasize the need for more rigorous studies to avoid overinterpretation. The potential geroprotective effects on various tissues are highlighted, alongside concerns about research transparency and incentives within the scientific community.

Subscribe to our channel: https://www.youtube.com/@optispan We recently came across a study published in the European Journal of Nutrition that examined the relationship between plant and animal protein intake and measures of biological aging. The study, which uses data from the UK Biobank, a long-term database of biological data from half a million participants in the United Kingdom, found that a higher plant protein intake correlates inversely with biological aging. Matt takes us through the study and gives us his take on the results and potential explanations for them as well as on the validity of the biological age measures used, the complexities of nutrition research, and core principles of healthy eating. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispan More about the Dog Aging Project: https://dogagingproject.org/ The Dog Aging Institute: https://dogaginginstitute.org Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/surveys/?s=DYYDHK8HAP We get lots of feedback and questions about the Dog Aging Project (DAP) from viewers, so we wanted to provide an update about how the project is going as well as some context. In this episode, Matt dives into the project's winding 10-year history, which includes navigating the vagaries of government funding, handling skepticism from fellow academics, and managing clinical trial enrollment in the midst of a global pandemic. He provides a candid peek into the logistical coordination, interdisciplinary collaboration, and leadership required to run a large-scale, ambitious scientific project such as the DAP, and the necessity of articulating clear and compelling goals that can rally support from both the scientific community and funding bodies. The DAP is a study of canine health and longevity aimed at understanding how dogs—and, eventually, humans—age. The project has two broad goals: to help us understand the biology of aging, and to enable us to do something about it. A third goal that often goes unmentioned, but is (to some) no less important, is to give us more time with furry friends who often become part of the family. The DAP has grown to become the world's largest study of aging. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Discover the four essential pillars of health that can transform your well-being. Dive into how eating, moving, sleeping, and connecting with others impact aging. Gain practical tips to identify your weakest area and take actionable steps to enhance your healthspan. Matt emphasizes the importance of self-assessment and using diagnostics for better long-term health outcomes.

Discover the latest findings from the PEARL trial, a groundbreaking study on rapamycin's potential to combat aging. Explore innovative dosing strategies, including an eight-on, four-off regimen, aimed at maximizing longevity. Delve into the differences between rapamycin and Everolimus, as well as the nuances in their effects on aging. Unpack the complexities and costs of conducting longevity trials, and learn why functional measures might be more effective than direct aging reversal metrics. Get ready for a captivating deep dive into the science of aging!