This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Harold Varmus The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science. Become a patron of TWiV! Links for this episode Varmus Laboratory Varmus and Kandel on Charlie Rose (transcript) Rescuing biomedical research Letters read on TWiV 400 Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode was made possible by PLoS Pathogens - the leading Open Access journal to publish breakthroughs in understanding pathogens and their interactions with host organisms and each other. PLOS Pathogens fosters the open exchange of ideas across fields, publishing original research on viruses, bacteria, fungi, parasites, and prions. For more information, check out www.plospathogens.org Weekly Science Picks Alan - A year on EarthRich - TWiV #1: West Nile Virus Dickson - Chasing storms, chasing beautyKathy - Bioartography and FASEB image and video competitionVincent - The Art and Politics of Science by Harold Varmus (free download) Listener Picks Trudy - Scientific Studies on Last Week Tonight with John Oliver Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. Links for this episode Zika virus disease in the US (CDC) Female to male Zika virus transmission (CDC) Zika virus in female genital tract (Lancet) Zika virus transmission in Utah (CDC and NYTimes) Olympic Zika virus risk (CDC) 15 companies on Zika virus vaccines (WSJ) Zika virus DNA vaccine in mice (Nature) Zika virus disease in Colombia (NEJM) Dengue virus antibody dependent enhancement of Zika virus (PNAS) Zika virus antibodies enhance dengue virus disease (Science) Zika virus in human placenta and developing brain (bioRxiv) Zika virus targets different human placenta cells (Cell Host Microbe) Letters read on TWiV 399 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Become a patron of TWiV. Weekly Science Picks Alan - CDC postmortem on Ebolavirus outbreakRich - Refutations to anti-vaccine memes (Twitter, Facebook) Dickson - History of urbanizationVincent - How to cut subject from background in Photoshop Listener Picks Marion - Skeptics Guide to the Universe podcastJennie - Leatherback turtles in Costa Rica Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello Guest: Sandy Weller Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes. Become a patron of TWiV! Links for this episode Cell killing by avian leukosis virus (Sandy's first paper, J Virol) ND10 protein and herpes simplex virus replication (J Virol) Recombination promoted by DNA viruses (Ann Rev Micro) HSV-1 and DNA damage response (Fut Virol) Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello Guest: David Tuller Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released. Become a patron of TWiV! Links for this episode Science and journalism (TWiV 111) Chronic fatigue syndrome and the CDC (virology blog) PACE trial (Lancet) Trial by error part one, two, three (virology blog) PACE economics analysis (PLoS One) All articles by David Tuller at virology blog Valerie Eliot Smith's blog Karina Hansen, prisioner of Denmark This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello Guest: Peter Palese Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines. Become a patron of TWiV! Links for this episode Palese Laboratory Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem) DNAse in cytoplasmic DNA virus (Virology) Inhibitor of influenza virus neuraminidase (Virology) Influenza neuraminidase defective mutants (Virology) Swine influenza virus of 1976 RNA pattern (Nature) 1977 influenza H1N1 similar to 1950s strains (Nature) H5N1 influenza: Facts, not fear (PNAS) Influenza HA stalk immunity in ferrets (J Virol) This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Stephen J. Russell From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers. Become a patron of TWiV! Links for this episode Hokies go viral (TWiV 285) MV NIS de Myelo (TWiV 298) Remission of disseminated myeloma after MV treatment (Mayo Clin Proc) miRNA detargeting (J Virol) Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Kathy - Can you explain your science in 30 seconds? and How Far Can We Go?Rich - Small asteroid Earth's companionVincent - The Gene by Siddhartha Mukherjee Listener Picks Dylan - Microsculpture by Levon Biss (website) Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello and Alan Dove Guest: Erica Ollmann Saphire Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA. Become a patron of TWiV! Links for this episode Structure of antibodies bound to Ebola virus glycoprotein (PNAS) Structure of cross-reactive filovirus antibody (Cell) Multiple functions of Ebola virus VP40 protein (Cell) View video of this episode on YouTube Letters read on TWiV 394 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Slime LapseVincent - Virus Watch Listener Picks Patricia - NECSS, People Behind the Science, The Life Scientific Peter - Iron Lung on eBay Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation. Become a patron of TWiV! Links for this episode Late sexual transmission of Zika virus (Lancet) Zika virus disease in US (CDC) Zika virus lab accident (ABC News) Mosquito eradication (virology blog) Florida mosquito control (TWiV 111) How tequila mosquito (TWiV 178) SEC14L2 allows HCV replication in cell culture (Nature) Lipid peroxidation (Wikipedia) HCV replicase regulated by lipid peroxidation (Nat Med) Letters read on TWiV 393 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Also brought to you by ASV 2016 Weekly Science Picks Alan - All About That SpaceRich - The Expanse by James S.A. Corey (SyFy) Kathy - Five Pivotal Paragraphs in a PaperVincent - Agar Art Contest Winners Listener Picks Ted - Marshall Niremberg charts Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC. [powerpress url="http://traffic.libsyn.com/twiv/TWiV392.mp3"] Click arrow to play Download TWiV 392 (62 MB .mp3, 85 min) Subscribe (free): iTunes, RSS, email, Google Play Music Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: David Pride and Forest Rohwer If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool. Links for this episode Lytic to temperate switching of viral communities (Nature) Viromes in ancestral holobiont Hydra (PLoS One) Phage in human oral cavity (J Oral Micro) Human oral viruses are personal, consistent, gender specific (ISME) Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Vax Pack HeroRich - Helicopter autorotation Vincent - Live in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa Listener Picks Matt - Experiment.com Send your virology questions and comments to twiv@microbe.tv