This Week in Virology

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guests: Sharon Isern and Scott Michael Become a patron of TWiV! Links for this episode Hurricane Zika (TWiV 410) 454 Corporation (Wikipedia) Regional Zika update, Americas (PAHO, WHO) Zika virus serum bank (pdf) Zika virus evolution and spread in the Americas (Nature) Multiple introductions of Zika virus in US (Nature) Inhibition of Zika Virus Replication by Wolbachia (J Virol) Zika virus pathogenesis in rhesus macaques unaffected by immunity to dengue virus (Nat Commun) Impact of flavivirus immunity on Zika virus infection in rhesus macaques (PLoS Path) Enhancement of Zika virus pathogenesis by antiflavivirus immunity (Science) No ADE by dengue antibodies in Zika virus patients (Clin Inf Dis) Oropharyngeal mucosal transmission of Zika virus in rhesus macaques (Nat Commun) Letters read on TWiV 454 Weekly Science Picks Dickson - Industrial Scars Kathy - Eclipse info by zipcode Sharon - Michaela's article in The Conversation Scott - Signal P, Pecaan, Phamerator, DNAmasterAlan - The Eagle Whisperer" (and the Great Big Story channel) Vincent - Bottle Listener Pick Kevin - Tenure track scientist bites the dust Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system. Hosts: Vincent Racaniello and Dickson Despommier Guest: Diane Griffin Become a patron of TWiV! Links for this episode Vector-Borne Viruses Symposium Diane Griffin Adoptive immunization of immunosuppressed mice infected with Sindbis virus Role of the immune response in age-dependent resistance of mice to encephalitis due to Sindbis virus Antibody-mediated clearance of alphavirus infection from neurons Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene Bc1-2 protects mice against fatal alphavirus encephalitis This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Guest: Lynda Coughlan Become a patron of TWiV! Links for this episode Linda on Virus Watch and BSGCT Anti-influenza peptide from frogs (Immunity) Magainins (Wikipedia) Urumi Kathy's defensin paper (PLoS Path) World Hepatitis Day Mouse model for hepacivirus infection (Science) Letters read on TWiV 452 Weekly Science Picks Kathy - US rivers as subway map Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot Alan - Apollo-era computers found in dead engineer's basement Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental Listener Pick Stig - Security Now! and The Gene by Siddhartha Mukherjee Ricardo - John Oliver on Vaccines Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Driving past a milestone (TWiP 100) Debug Fresno (Verily blog) What could possibly go wrong? (TWiV 388) Chestnut blight (ProMedMail) Hypovirus molecular biology (Adv Virus Res) Mosquitoes transmit unique WNV populations (Cell Rep) Teaching science using pseudoscience Image credit Letters read on TWiV 451 Weekly Science Picks Kathy - Approaching Jupiter and Michigan parents about vaccination Rich - Math Limericks from Futility Closet Alan - NASA flyover of Pluto Vincent - Talk show host nominated as USDA chief scientist Listener Pick Neil - These smart girls are here to debunk anti-vaxxer nonsense John - John Sever AMA Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Ben tenOever Become a patron of TWiV! Links for this episode RNAseIII is an ancient antiviral effector (Nature) Influenza suppression of RNAi (PNAS) Questioning mammalian antiviral RNAi (Nat Micro) Antiviral protection via RdRp (PLoS Path) Evolution of antiviral defense (Cell Host Micr) Letters read on TWiV 450 Weekly Science Picks Ben - Invisible Invaders by Peter Radetsky Kathy - ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force Rich - Columbia river gorge and Undaunted Courage by Stephen Ambrose Dickson - All the World's Earthquakes Alan - Map of Roman roads Vincent - Brain atlas of fly behavior Listener Pick Rob - Vaccinate Your Kids and Charles Darwin Natural Selection Islam - Self-assembling virus and Virus Patterns Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Facial appearance affects science communication (PNAS) Your face matters to science (virology blog) RNA based antiviral immunity in mammals (Immunity) How mice say nodavirus (TWiV 245) Press release on science meeting gender disparity The Traditional Lecture is Not Dead. I Would Know – I'm A Professor (virology blog) Sound of Silence by Disturbed (YouTube) Letters read on TWiV 449 Weekly Science Picks Kathy - ASV 2017 Virolympics Crossword (pdf) Dickson - The Visible Mouse Alan - Is profitable publishing bad for science? Vincent - Locally Sourced Science Listener Pick Neva - Michael Summers interview and Virus coloring book Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Mavis Agbandje-McKenna Become a patron of TWiV! This episode of TWiV is sponsored by Promega Corporation. Promega is a leader in providing innovative solutions and technical support to the life science industry. The company's 3,500 products support scientists' worldwide to advance their knowledge in genomics, proteomics, cellular analysis, drug discovery and human identification. Founded in 1978, the company is headquartered in Madison, WI with branches in 16 countries and over 50 global distributors. Promega products are used by life scientists who are asking fundamental questions about biological processes applying their knowledge to diagnose and treat diseases or discover new therapeutics. For more information about Promega, visit www.promega.com/ASV Weekly Science Picks Kathy - Doktor Kaboom! Dickson - Mars as you've never seen it before Alan - Eclipse 2017 Rich - Sirens of Titan by Kurt Vonnegut Vincent - Research!America Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions! Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Female role models in engineering (PNAS) Gender equity at ASM meeting (mBio) Invisible Frontiers Time, Love, Memory The Eighth Day of Creation Predatory journals recruit fake editor Photo by Anthony Olszewski Letters read on TWiV 447 Weekly Science Picks Kathy - Oskar Fischinger Google Doodle Dickson - Ten Tiny But Terrifying Micro Monsters Alan - Hunting mammoth ivory in Siberia Rich - Occam's razor Vincent - Blame vax for illness without proof, says EU Listener Pick Ed - Lysenkoism Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Gender parity trends at virology meetings (J Virol) Professor gender perpetuates gender gap (NBER) Next generation researchers initiative (NIH) NIH abandons grant cap (Science) Genesis and pathogenesis of 1918 H1N1 influenza virus (PNAS) Image credit Letters read on TWiV 446 Weekly Science Picks Kathy - BioKids Critter Catalog Dickson - Shanghai Vertical Farm Alan - Colossal Cave Adventure open source Rich - Life on Mars (HI-SEAS) Vincent - TWiM 154 with Arturo Casadevall Listener Pick Grant - Antibody validation challenges Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From Nido2017 in Kansas City, Vincent meets up with three virologists to talk about their careers and their work on nidoviruses. Host: Vincent Racaniello Guests: Margo Brinton, Luis Enjuanes, and Linda Saif Become a patron of TWiV! Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS) Norovirus binding to lettuce (Appl Env Micro) This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv