TWiV 453: Neurovirology with Diane Griffin

From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Diane Griffin

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Links for this episode

• Vector-Borne Viruses Symposium
• Diane Griffin
• Adoptive immunization of immunosuppressed mice infected with Sindbis virus
• Role of the immune response in age-dependent resistance of mice to encephalitis due to Sindbis virus
• Antibody-mediated clearance of alphavirus infection from neurons
• Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis
• Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene
• Bc1-2 protects mice against fatal alphavirus encephalitis

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Intro music is by Ronald Jenkees.

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