This Week in Virology

At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager. Host: Vincent Racaniello Guest: Roland R. Rueckert Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Video of this episode (YouTube) Roland's first paper (Anesthesiol) Purification of phiX174 (Virology) Studies on viral structure (Virology) Automated gel fractionator (Anal Bioch) Picornaviral gene order (J Virol) Picornavirus protease discovery (J Virol) Poliovirus processing map (J Virol) Nomenclature of picornavirus proteins (J Virol) Black beetle virus (J Virol) Rhinovirus crystallization (PNAS) Mapping mAb binding sites (J Virol) Replication of animal virus in yeast (PNAS) Roland's last paper (J Virol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research TWiV World Tour 2018 t-shirt (Amazon) Cool virology from 2018 Viruses behind AD? TWiV 505, TWiV 519, clinical trial one and two Wolbachia-mosquito release halts dengue (TWiV 506); World Mosquito Program Evolutionary history of RNA viruses: TWiV 491 and TWiV 526 Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478 Ebola continues: TWiV 494, TWiV 495, TWiV 505, TWiV 507, TWiV 515, TWiV 482 Clues to many mysteries: TWiV 481, TWiV 484, TWiV 493, TWiV 515, TWiV 522 Pro-vaccination: TWiV 500, TWiV 496, TWiV Special; measles in Ukraineand Europe Outbreak influence: TWiV 501, TWiV 527, TWiV 520, TWiV 507, TWiV 504 Insect viruses and immunity: TWiV 525, TWiV 524, TWiV 522, TWiV 495, TWiV 485, TWiV 482, TWiV 479 Big RNA virus genomes (TWiV 509) and Giant viruses: TWiV 490, TWiV 506, TWiV 521, TWiV 484 Letters read on TWiV 528 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Pandemic Trail game Rich- On a Bat's Wing and a Prayer Dickson- Decoding Watson Kathy- Phenotypic variation in outbred and inbred mice Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers Listener Pick Anne- Peter Hotez interview Islam- Letter from Crick to Watson (pdf) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak (exhibit, TWiV 501) Four Corners hantavirus outbreak (Wikipedia) Death at the Corner (Atlantic) Hantavirus infection by US state (CDC) Hantavirus US cases and mortality (CDC) Hantavirus international cases (CDC) Belmont hantavirus death (NYTimes) Intestinal dysmotility following flavivirus infection of mice (Cell) Image credit Letters read on TWiV 527 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom Listener Pick Neal- The Yoda of Silicon Valley Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Aaron Klug, 1926-2018 (Nature) Prions in sCJD eyes (mBio) Evolution of RNA viruses (mBio) Walter Gilbert's The RNA World (Nature) Image credit Letters read on TWiV 526 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Population mountains to visualize cities Rich- A Neanderthal Perspective on Human Origins with Svante Pääbo Kathy- NASA Space Mission posters Vincent - Package Thief vs Glitter Bomb Trap Listener Pick Neal- Was a Scientist Jailed? Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism. Host: Vincent Racaniello Guest: Peter Hotez Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Peter Hotez at Baylor College of Medicine Peter Hotez on Twitter Vaccines Did Not Cause Rachel's Autism (Amazon) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michelle Flenniken Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MSU Pollinator Health Center Honeybee antiviral defenses (Sci Rep) The buzz about honeybee viruses (PLoS Path) Recently identified bee viruses (Curr Op Insect Sci) Videos on honey bee researchat MSU, honey bee pathogens, honey bee pathogen detection (YouTube) Timestamps by Jolene. Thanks! Weekly Science Picks Michelle - First 21 days of a bee's life; NPR's Hidden Brain; Varroa destructor triggers deformed wing virus in bees Brianne - Flu Near You Alan - Skype a Scientist program Rich- NASA's Voyager 2 Probe Enters Interstellar Space Kathy- Which ones are bees? And What it feels like to be a bee Vincent - Fecal sequencing and Vaccines did not cause Rachel's autism by Peter Hotez Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein. Hosts: Vincent Racaniello and Amy Rosenfeld Guest: Raul Andino Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TWiV 138: RISCy business with Raul Andino TWiV 33: Live in Philly Viral protein restricts insect immunity (Cell Host Micr) Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Insectropolis Vincent- Genome-edited baby Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. Hosts: Vincent Racaniello Guests: Cornel Fraefel, Urs Greber, and Silke Stertz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode AAV2 and HSV1 co-infections (J Virol) Movies of HeLa Fucci cells (J Virol) Cathepsin W and influenza virus entry (mBio) Plaque 2.0 (PLoS One) Video of this episode (YouTube) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Genome-edited babies (Nature) Second CRISPR pregnancy? (MIT Tech Rev) Naturally occurring DNA virus of Drosophila (PLoS Path) Upstream protein coding region in enterovirus genome We missed it in 1988! (J Virol) Letters read on TWiV 522 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - $40 internationally standard cup of tea Rich- Mars InSight Mission Dickson- New York Botanical Garden Train Show Kathy- Comedy wildlife photo awards finalists Vincent - Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research Listener Pick Fernando - Pathfinders by Felipe Fernández-Armesto; Erebus by Michael Palin Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai 30,000 year old Mollivirus sibericum (PNAS) Aggregating viruses promotes early replication (Curr Biol) Letters read on TWiV 521 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Why don't we have vaccines against everything? Rich- Golden Globe Race Dickson- The Anatomy of Figure Drawingby Robert Demarest and Warder Clyde Allee Kathy- Orientation of the moon's appearance, Southern Hemisphere Vincent - Paul has Measles in English and Spanish Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv