This Week in Virology

TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Animal sales from Wuhan markets before COVID-19 (Sci Rep) Dengue control by Wolbachia-infected mosquitoes (NEJM) Fatal dengue in Florida (NEJM) Letters read on TWiV 776 Timestamps by Jolene. Thanks! Weekly Picks Brianne – You Know You’ve Worked Too Long in a Lab When… Alan – Massachusetts vaccine lottery Vincent – Coonhound paralysis Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Worry about human behavior, not variants (NY Times) Moderna and Pfizer vaccines vs delta variant Depression among public health workers (MMWR) Correlates of protection (medRxiv) mRNA vaccine in AZ recipients (Lancet) Prior infection rescues B and T cell responses to variants (Science) Effect of vaccination on household transmission (NEJM) mRNA vaccines induce germinal responses (Nature) Novavax vaccine phase 3 results (NEJM) EUA for tocilizumab (FDA) Long COVID, next national health disaster (NEJM) Letters read on TWiV 775 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guests: Kristian Andersen and Robert Garry Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Andersen laboratory Recovery of deleted deep sequencing data (bioRxiv) Animal sales from Wuhan wet markets (Sci Rep) Danielle Anderson on Wuhan Lab (Bloomberg) Timestamps by Jolene. Thanks! Weekly Picks Kathy – STEVE over Copper Harbor, MI Vincent – Human Behavior During the Pandemic Is More Important Than Any Covid Variant Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Laurie Garrett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lauriegarrett.com The Coming Plague Betrayal of Trust Trump sabotaged coronavirus response (Foreign Policy) ASV Vaccine Town Hall Timestamps by Jolene. Thanks! Weekly Picks Brianne – A Pivotal Mosquito Experiment Could Not Have Gone Better Kathy – Microbiology at the Movies Vincent – When a Good Scientist Is the Wrong Source Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 and birthday parties (JAMA) Vaccines in transplant patients (Ann Int Med) Reinfection of recovered patients (Clin Inf Dis) Azithromycin lack of efficacy (Rev Med Virol) Bacterial and fungal infections in hospitalized patients (Op For Inf Dis) mAb treatment of ambulatory patients (Op For Inf Dis) Remdesivir reduction of mortality (Gilead) Letters read on TWiV 772 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2. Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 100 million year old bornavirus infections (PNAS) Bornaviruses across geological timescales (PNAS) Bornaviruses previously on TWiV 303, 347, 548 Novel bat SARS-CoV-2 related coronaviruses (Cell) Letters read on TWiV 771 Timestamps by Jolene. Thanks! Weekly Picks Amy – A relic from the Jurassic era Alan – World of Wonders, by Aimee Nezhukumatathil Vincent – Tom Buck’s YouTube Channel Listener Pick Victor – Vaccines: A measured response Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Antiviral antibodies early in US outbreak (CID) Serologic testing of US blood donations (CID) The virus, what went wrong (PBS) MIS-C in children (JAMA) Myocarditis in competitive athletes (JAMA) ER visits for suspected suicide (MMWR) Delta variant in Scotland (Lancet) Novavax phase 3 results (Novavax) Vaccine coverage in pregnant women (MMWR) Early mAb reduces hospitalization and mortality (CID) Regen-Cov trial results (Regeneron) Guidance on postacute sequelae (CDC) Letters read on TWiV 770 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Click arrow to play Download TWiV 769 (68 MB .mp3, 114 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 Novavax vaccine efficacy reported (Novavax) H3N2 glycosylation in eggs (TWiV 480) Preventing antigenically disruptive HA change in eggs (Cell Host Micr) MIS-C due to leaky gut (J Clin Invest) Letters read on TWiV 769 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Pandemics for Babies, Germ Theory for Babies, and Vaccines for Babies Kathy – Playing with Time Vincent – A Top Virologist in China, at Center of a Pandemic Storm, Speaks Out Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall Spread of SARS-CoV-2 variant in summer 2020 (Nature) Nanobodies neutralize SARS-CoV-2 variants (Nature) Letters read on TWiV 768 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Hotel Magdalena Brianne – Antibody Song by Raven the Science Maven Alan – How to play Magic: the Gathering Vincent – Steve Gibson’s rant on Security Now Listener Pick David – Coronavirus set to mu Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 treatment guidelines (IDSA) Hospitalization of adolescents (MMWR) Estimating dynamics from viral load (Science) Incidence according to antibody status (Lancet) Reinfections in Italy (JAMA) Need for vaccination in previously infected (medRxiv) Assessment of protection against reinfection (ACC) Antimicrobial use in hospitalized patients (Lancet) Effect of single dose ivermectin (Viruses) Aspirin in hospitalized patients (medRxiv) Letters read on TWiV 767 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv