This Week in Virology

Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Cross-reactive enterovirus antibodies (mBio) Poliovirus receptor transgenic mice (virology blog) Timestamps by Jolene. Thanks! Weekly Picks Dickson – European scientists set new record in production of nuclear fusion energy Amy – Alfredo’s Magic Wand Brianne – What Happened After the Chicken-Pox Vaccine? Rich – Year Three of COVID-19: Harsh Truths, Realities, and Glimmers of Hope Vincent – Economists Are Fueling the War Against Public Health Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children and COVID state data (AAP) Human challenge study (Res Sq) Effectiveness of mask use (MMWR) Omicron boost in macaques (bioRxiv) Mucosal vaccine candidate (Cell) Long-term cardiovascular outcomes (Nat Med) Global vaccine perceptions (PLoSNTD) Letters read on TWiV 865 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guests: John Dennehy, Marc Johnson, Davida Smyth, and Monica Trujillo Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 in NYC wastewater (TWiV 737) Cryptic SARS-CoV-2 in NYC wastewater (Nat Comm) Timestamps by Jolene. Thanks! Weekly Picks Brianne – When scientific conferences went online, diversity and inclusion soared Rich – Traffic flow measured on 30 different 4-way junctions Vincent – A Slot Machine, a Broken Test Tube by S.E. Luria Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position 3:27 UK SARS-CoV-2 challenge study (Res Sq) U of Pennsylvania smell test (Wikipedia) Letters read on TWiV 863 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Webb team begins aligning telescope Brianne – Our Solar System in True Color Is Really Something Else Rich – When the International Space Station retires, it will plunge into the ocean to die Vincent – Gateway Program and What One Really Expensive Means to US Train Travel Listener Picks Jack – Dr. Becky and Pasta or composer Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron severity challenges (NEJM) Children and COVID data (AAP) Vaccine EUA for under 5 year olds (Pfizer) B cell boot camp (Immune 52) Soft drink and LFA false positives (medRxiv) EUA application for Novavax vaccine (Novavax) Childhood experiences and vaccine hesitancy (BMJ Open) Fourth vaccine dose in Israel (medRxiv) Antibodies and antivirals vs Omicron (NEJM) Paxlovid and Omicron (Pfizer) Multiple factors and PASC (Cell) Internship at Parasites Without Borders (pdf) 28:47 Letters read on TWiV 862 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Nels Elde Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position Did Omicron come from mice? (J Genet Genomics) Persistent SARS-CoV-2 infection (SSRN) Letters read on TWiV 861 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Groundhogs Emerge From the Scientific Shadows Kathy – Zig-zag Coast Guard search pattern Rich – Moon Phases 2022 (Lunar Reconnaissance Orbiter) Vincent – Kevin Cowtan’s Book of Fourier and Live Fourier Transformation Nels – Biology versus bias Listener Picks Dusty – Fighting bias in space Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position RNA modifications suppress innate recognition (Immunity) Critical contribution of pseudouridine (Front Cell Dev Biol) Rich Condit reminisces (YouTube) Letters read on TWiV 860 Timestamps by Jolene. Thanks! Weekly Picks Dickson - NASA Research Launches a New Generation of Indoor Farming Kathy -How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral Rich - Fermi paradox Vincent - Racism not Race by Joe Graves Listener Picks Jay – Restoration of Ave Maria John – Pandemic humor Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron disease severity (MMWR) Neurologic manifestations in children (Pediatric Neurol) Respiratory virus interference (Emerg Inf Dis) Hospitalization by vaccination status (CDC) Third vaccine dose VE (MMWR) Vaccination induces cross-reactive T cells (Cell) Limitations for monoclonal antibody use for Omicron (FDA) Internship at Parasites Without Borders (pdf) 42:40 Letters read on TWiV 859 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: John Mascola Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Accelerated COVID-19 vaccine development (Immunity) Letters read on TWiV 858 Timestamps by Jolene. Thanks! Weekly Picks Brianne – How Sesame Street is Handling the Pandemic Rich – Zamboni: How it works Alan – How lightning starts Vincent – Buon-A-Petitti Listener Picks Meika –Wordle Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Jon Yewdell on TWiV 208, 467, 597, 620 Letters read on TWiV 857 Timestamps by Jolene. Thanks! Weekly Picks Jon – The Premonition by Michael Lewis Dickson – Nature photographer of the year 2021 Brianne – Should BioBank Volunteers Be Warned About Mutations? Rich – Czech singer Hanka Horká dies after intentionally getting infected by the coronavirusand Dena Dietrich Dies at 91 Vincent – Cuore di Cioccolato Listener Picks Bronwen – Schools must stay open John – Pandemic humor Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv