This Week in Virology

Paul Offit joins TWiV to discuss his latest book, “Tell Me When It’s Over”, an insider’s guide to deciphering COVID myths and navigating our post-pandemic world. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Tell Me When It’s Over by Paul Offit Navigating the U.S. Immigration System (webinar) Classifying Viral Subspecies (Workshop) Options XII for the Control of Influenza (Meeting) Letters read on TWiV 1101 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way’s Central Black Hole Brianne – Inside the AI Competition That Decoded an Ancient Herculaneum Scroll Vincent – biotech.symposium on Instagram Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the “oral remdesivir”, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) What new monoclonal antibody therapy? (FDA) A New pre-exposure prophylaxis for COVID-19? (Invivyd) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Really COVID-19 rebound after Nirmatrelvir-ritonavir treatment? (JAMA Network Open) Can vaccines and antiviral be effective for COVID-19 together (International Journal of Infectious Diseases) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Can loss of infectivity among healthcare works with mild and recurrent COVID-19 be predicted (CID) Household transmission dynamics in children with asymptomatic infection (CID) Steroids,dexamethasone at the right time (OFID)Anticoagulation guidelines (hematology.org) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1098 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus. Host: Vincent Racaniello Guests: Volker Lohmann Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier HCV human challenge studies (Lancet Gastro Hepatol) Comparison of HCV and HAV infections (J Hepatol) HCV cell culture systems (J Med Chem) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Measles in Cook County (MMWR) Gaps in measles vaccination drives viral surges (Infectious Disease Advisor) Misinformation impacts public health? Seriously? (ID Society) CDC alert for global and domestic measles cases and outbreaks (CDC) Mpox in Kamituga associated with outbreak in DRB (Eurosurviellance) Mpox in US, 2023 (MMWR) Mpox in DRC, 2024 (reliefweb) CDC guidance for respiratory diseases, COVID antiviral & emergence of clade I mpox (ID Society) ~5% of infected dead from mpox (CIDRAP) First cases of mpox in Republic of Congo (AP News) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Multisystem inflammatory syndrome in children 2023 (MMWR) Guidance for COVID-19 in children and adolescents (JPIDS) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Molnupiravir safety and efficacy (JMV) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) High/low oxygenation target (JAMA) How much oxygen is needed (JAMA) Orthostatic intolerance in long COVID and healthy volunteers (JMV) Autonomic cardiac function in children and adolescents with long COVID (European Journal of Pediatrics) Long COVID iron dysregulation and inflammatory stress erythropoiesis (Nat Imm) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1098 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes. Host: Vincent Racaniello Guests: Sheree Yau and Victoria Queiroz Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier 8:16 Virophage control of antarctic algal host-virus dynamics (PNAS) Timestamps by Jolene. Thanks! Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv) Two groups of pithoviruses (J Virol) Educational toolkit for virology classes (J Virol) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles everywhere (CDC) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Estimating niresevimab effectiveness for infants (MMWR) More than 100 children died of influenza (NBS News) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Did the vaccine protect children against Long COVID (Pediatrics) Did COVID-19 vaccination impact cardiovascular diseases? (Nat Comm) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Updated respiratory infection guidelines (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID trial for autonomic nervous system dysfunction (NIH) Nirmatrelvir-ritonavir impact on myocardial injury and long-term cardiovascular outcomes in COVID-19 hospitalized patients (Cardiovascular Drugs and Therapy) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1096 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis) Continued circulation of oropouche virus (PAHO and WHO) Herpesviruses in fur seals and sea lions (PLoS One) Sex-specific effects of SARS-CoV-2 infection (PLoS One) Drivers of 2022 Mpox virus epidemic (Cell) How AAV gene transfer works (YouTube) Humanized mouse model for AAV gene therapy (Nat Comm) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Baden Powell – Manha de Carneval Angela – Upcoming Health & Fitness podcast from MicrobeTV Rich – Mark Smith Photography Alan – OpenVertebrate (and Science article on it) Vincent – Veterinary apparel for the veterinary nerd Listener Pick Anne – Why Reed Jobs is betting on cancer innovations Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) What to do when you are sick with a respiratory virus (CDC) Basis for respiratory virus guidance (CDC) Effectiveness of updated COVID-19 vaccines (MMWR) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Synergy or additive protection with vaccination and oral antivirals (CID) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Still talking about Ivermectin? (Journal of Infection) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Cognition and memory after COVID-19 (NEJM) Loss of IQ after SARS-CoV-2 infection (CIDRAP) Really, more evidence for long COVID and impaired cognition (NEJM) Memory assessment before and after COVID-19 (NEJM) Please complete this memory questionnaire (Community hyperbaric) Impact of long-term COVID-19 on workers in healthcare settings (PLoS One) Healthcare workers have difficulty assessing long COVID (CIDRAP) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1094 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses effectiveness of this season’s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Effectiveness of flu vaccine (MMWR, Eurosurveill) Efficacy of Pfizer RSV vaccine (Pfizer) Understanding six types of vaccine technologies (Pfizer) nOPV in US? (CDC) Dengue in Peru (Peruvian State) Measles in Michigan and Indiana Marburg virus control by reservoir bats (Nat Commun) tRNA acquisition by phages (Cell) Viruses of Microbes 2024 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The reappearance of Lake Manly Kathy – “Practical Playbook for Addressing Health Misinformation” Rich – Making It So: A Memoir by Patrick Stewart Jolene – Thinking Like a Phage by Merry Youle Vincent – The Science of Leap Year Listener Picks Blog design – Anthony Fauci will reflect on his long government career in ‘On Call,’ to be published in June Peter – Republican warns of vaccines being slipped into vegetables: ‘A polio vaccine in there’ Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) RSV vaccination stats (CIDRAP) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) ACIP COVID vaccination for seniors recommendations (CIDRAP) Additional vaccine doses for older adults (CDC) Evidence based advice from the ACIP (CDC) State mandates did NOT influence primary vaccination rates only boosters (PNAS) No nOPV2? (CDC) CDC Quarantine guidelines (CDC) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Molunpiravir plus antibody therapy for at-risk outpatients (Nat Comm) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Spontaneous release of IFN-g in Long COVID (Science Advances) Blood-brain-barrier compromise in long COVID associated cognitive impairment (Nat Neuroscience) Persistent community SARS-CoV-2 RNA (Nature) Hyberbaric oxygen therapy improves post COVID neurocognition (Scientific Reports) Medical study questionnaire, the SHORT form (Brandeis) Long term effects of hyperbaric oxygen post COVID (Scientific Reports) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1092 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv