This Week in Virology

In his weekly clinical update, Dr. Griffin discusses Dr. Fauci's case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Fauci recovering at home from West Nile Virus infection (STAT News) Gaza: poliovirus RNA in sewage water (GPEI) Bombs and polio…..cease fire, Oh my! (Guardian) The variant type 2 poliovirus in Gaza (United Nations: The Question of Palestine) 25 years polio free? (Facebook) 2 doses of nOPV2= 1.2M vaccines=640,000 children (CNN) More polio……India, two-year-old child in Tikrikilla, Meghalaya (Business Standard) Sloth fever……Oropouche virus (USA Today) Oropouche virus disease import into US (MMWR) Gabon's first case of mpox (CIDRAP) Declaration of mpox (Gabonese Republic Ministry of Health and Social Affairs) What about vaccines? (Bavarian Nordic) LC16 replicating smallpox vaccine (WHO) Historical smallpox vaccination against mpox clade II (Eurosurveillance) FDA approves Emergent Bio's smallpox vaccine for mpox (Reuters) Mpox: epidemiology and vaccinology (Emerging Infectious Disease) Tecovirimat for MPOX? (STOMP) UGH! The WHO has a strategic preparedness and response plan to contain mpox outbreak (WHO) WHO preparedness plan prepares to lunch (CIDRAP) Working blindly against new mpox isolate (Reuters) CDC monkey pox response: TRANSMISSION ? (CDC Newsroom) The mpox (Africa CDC: Centers for Disease Control and Prevention) Evidence for mpox respiratory transmission(LANCET Microbe) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Four free COVID tests! (ASPR: Administration for Strategic Preparedness & Response) Great, more SARS-CoV-2 testing! (CIDRAP) EUA for updated Novavax COVID-19 vaccine (FDA) Infectious Disease Society guidelines for treatment and management (ID Society) IDSA suggests new preventive COVID-19 agent (IDSA) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Breakthrough from pemivibart/permgarda (bioRxiv) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Effectiveness of nirmatrelvir/ritonavir preventing hospitalization of high risk patients (Current Therapeutic Research) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) COVID-19, mental illness vaccinated and unvaccinated (JAMA Psychiatry) Post acute COVID- 19 outcomes amubarvimab/romlusevimab versus placebo (eClinical Medicine) Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID) Fibrin drives thromboinflammation & neuropathology in COVID-19 (Nature) Letters read on TWiV 1144 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mpox outbreak is PHEIC (WHO) Tecovirimat not great against monkeypox virus clade I (NIH) Case of Mpox Clade I in Sweden (PHAS) Mpox and pets in USA (Emerg Inf Dis) SARS-CoV-2 widespread in wildlife communities (Nat Comm) Salivary GAPDH benefits plant virus transmission (Nat Comm) Letters read on TWiV 1143 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NASA Confirms Evidence That Liquid Water Flows on Today's Mars Kathy – TBP for PCR internal control Rich – xmACIS2 compares the data in the ACIS database to that in GHCN-Daily Alan – Larry, the world's most highly cited cat Vincent – The Viral Paleontologist Who Unearths Pathogens' Deep Histories Listener Pick Ryan – Mpox emergencies AP News one and two Rona – Up in smoke David – Ode to Joy (YouTube, TikTok) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US's aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mpox epidemic caused by monkeypox clade I in affected African countries (European Centre for Disease Prevention and Control) mpox in Pakistan (Reuters) mpox imported into Pakistan (UNMC Global Center for Health Security) mpox domesticated in Taiwan (Focus Taiwan: CAN English News) clade IIb not Ib in Taiwan (bne Intellinews) WHO: mpox public health emergency of global care (NY Times) Vaccines didn't turn back mpox…..people did (NY Times) Deadlier mpox version in Thailand (NY Times) Antiviral tecovirimat….not so much (NIH News) What about vaccines? (Bavarian Nordic) Invest or not to invest Barvaian Nordic pox vaccine manufacturer? (Yahoo! Finance) US to support Africa's mpox response (CIDRAP) $35M to support mpox outbreak response in central and eastern Africa (USAID From the AMERICAN PEOPLE) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) FDA approves and authorizes updated mRNA COVID-19 vaccines (FDA) Novavax still working on updated COVID-19 vaccine (novavax) COVID-19 variant update (CDC & IDSA) Economic benefit of annual COVID-19 vaccination (JID) Early COVID-19 XBB.1.5 vaccine effectiveness (Influenza and other respiratory viruses) Uptake of COVID-19 vaccines and associated hospitalization due to COVID-19 in pregnancy (Vaccine) Novavax heterologous booster demonstrates lower reactogenicity (JID) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Breakthrough from pemivibart/permgarda (bioRxiv) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID differs in children and adolescents (JAMA Network) Letters read on TWiV 1142 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mpox widespread in Africa (CIDRAP) Africa declares Mpox emergency (Science) COVID drops to 10th leading cause of US deaths (MMWR) Response to detection of poliovirus in Gaza (WHO) Molecular mimicry in MIS-C (Nature) Neonatal Fc receptor is pan-arterivirus receptor (Nat Comm) Antiviral immunity in plants by protein arginine methytransferase 6 (Cell Host Micr) Letters read on TWiV 1141 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Kate Douglass: Olympian and Statistician (Swimming in Data) Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha'Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women's basketball team Rich – Texas State University Forensic Anthropology Research Facility Vincent – Sea lion 'camera crews' capture new footage of ocean floor Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles transmission after secondary vaccination failure (Emerg Inf Dis) Mpox public health emergency of international concern (WHO) First case of new mpox strain outside of Africa (Reuters) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Where to get pemgarda (Pemgarda CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) Individual monoclonal antibodies against SARS-CoV-2 should be used (CID) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID science, research and policy (Nature Medicine) Measurements of prior SARS-CoV-2 infection and postacute sequelae by the clinical laboratory (Annals of Internal Medicine) Risk factors for long COVID syndrome in postmenopausal women with previous SARS-CoV-2 infections (Annals of Epidemiology) New studies estimate long-COVID rates, identify risk factors (CIDRAP) Monitoring long COVID via telemedicine (PLoS One) Letters read on TWiV 1140 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID. Hosts: Vincent Racaniello Guest: Judith Bruchfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Immune system perturbations in Long COVID (J Immunol) Post-COVID immune system perturbations (J Immunol) Systems disregulation in Long COVID (Sci Rep) Clincal standards for diagnosing, treating, and preventing Long COVID (Intl J Tuberc Lung Dis) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Harms of the lab leak hypothesis (Journal of Virology) Lab leak mania (PaulOffit, Substack) This is a special message: pandemic started in nature! (TWiV) RSV vaccine recommendations August 6 2024 (MMWR) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Where to get Pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID defined (NEJM) Contribute to our Floating Doctors fundraiser Lenacapavir on Puscast #60 Letters read on TWiV 1138 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server PrEP with HIV-1 capsid inhibitor (NEJM) WHO pandemic plan (pdf) West Nile virus resurgence in US (NY Times) Properties of BANAL SARS-CoV-2 like viruses (Nat Micro) BANAL viruses on TWiV 809 Different effect of dengue virus amino acid change in humans and mosquitoes (Sci Transl Med) Eng Ong Ooi on TWiV 633 Letters read on TWiV 1137 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Using big data to improve traffic light timing Rich – Dillo Dirt Alan – Dueling Banjos on banjo and kora Vincent – The world's most expensive dinosaur and more Listener Pick Mike – Science through a glass darkly Lisa – On A Mission" Season Four Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode In physicians and hospitals, we trust (JAMA Network) Are there benefits for delaying seasonal influenza vaccine selections (JID) Personal protective effect for wearing surgical face masks in public spaces (the BMJ) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Cardiovascular safety of different COVID-19 vaccination(Nature Comm) Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine) Where to get pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology) Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health) Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine) The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1136 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server What's going on with measles? (J Virol) Poliovirus in Gaza (Science) Sanitation concerns in Gaza (AP) Community vaccine beliefs (PLoS One) 14 year old dies of Nipah in India (Hindustan Times) Selection of nirmatrelvir resistance mutants (Sci Adv) CCHFV monoclonal antibodies (Cell Rep) CCHFV vaccine (TWiV 565) Prometheus Project (TWiV 578) TWiV at USAMRIID (TWiV 1015) Letters read on TWiV 1135 Timestamps by Jolene. Thanks! Weekly Picks Angela – Animal research is not always king Brianne – Why the US has more tornadoes than any other country Dickson – Earth's core has slowed so much it's moving backward Alan – Article about the Smithsonian's forensic ornithology lab, led by Carla Dove Vincent – Seventh patient 'cured' of HIV: why scientists are excited Listener Pick Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.