The Incubator

Send us a textIn this episode of the Incubator: At the bench, we talk with, Dr. Augusto Zani, a pediatric surgeon scientist who discusses his work on fetal lung regeneration and the use of stem cell derivatives and extracellular vesicles for diagnostics and therapy. He shares his journey from surgical training to becoming a surgeon scientist and the challenges he faced along the way. Dr. Zani also explains his transition from studying necrotizing enterocolitis to congenital diaphragmatic hernia (CDH) and the unanswered questions in lung hypoplasia related to CDH. He highlights the importance of understanding the mechanisms behind these conditions and the potential of extracellular vesicles in promoting lung growth and regeneration. Dr. Augusto Zani discusses his research on congenital diaphragmatic hernia (CDH) and the potential use of extracellular vesicles (EVs) as a therapy. He also discusses the role of inflammation in CDH and how EVs have both regenerative and anti-inflammatory properties. Dr. Zani also mentions the potential use of EVs in other pediatric surgical conditions, such as gastroschisis and spina bifida. He concludes by sharing his excitement about moving his lab to St. Louis Children's Hospital in the U.S.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

This discussion dives into the impact of mpox on newborns, emphasizing recent case reports and treatment options. It also addresses the effectiveness of simultaneous vaccinations for preterm infants, showing no increased risks. Iron deficiency among extremely preterm infants is a surprising highlight, revealing troubling rates despite supplementation. The hosts further analyze the complexities of inguinal hernia repairs and the implications for neonatal care, all while sharing insights from a seasoned medical journal editor on research publication.

Send us a textMpox in Pregnancy - Risks, Vertical Transmission, Prevention, and Treatment.Nachega JB, Mohr EL, Dashraath P, Mbala-Kingebeni P, Anderson JR, Myer L, Gandhi M, Baud D, Mofenson LM, Muyembe-Tamfum JJ; Mpox Research Consortium (MpoxReC).N Engl J Med. 2024 Aug 28. doi: 10.1056/NEJMp2410045. Online ahead of print.PMID: 39197097 No abstract available. Neonatal Monkeypox Virus Infection.Ramnarayan P, Mitting R, Whittaker E, Marcolin M, O'Regan C, Sinha R, Bennett A, Moustafa M, Tickner N, Gilchrist M, Kershaw A, Rampling T; NHS England High Consequence Infectious Diseases (Airborne) Network.N Engl J Med. 2022 Oct 27;387(17):1618-1620. doi: 10.1056/NEJMc2210828. Epub 2022 Oct 12.PMID: 36223535 No abstract available.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textDon't wait, vaccinate: evaluation of routine vaccination administration and reactogenicity in preterm infants.Abdelmessih E, Desai PV, Tracy J, Papadopoulos J, Bashqoy F.J Perinatol. 2024 Sep 10. doi: 10.1038/s41372-024-02111-1. Online ahead of print.PMID: 39256613Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textPrevalence of iron deficiency in extreme preterm infants at 4 or 6 months corrected age despite receiving prophylactic iron supplements.Barr H, Morrison L, Kulkarni K, Ghotra S.J Perinatol. 2024 Aug 29. doi: 10.1038/s41372-024-02103-1. Online ahead of print.PMID: 39210023 No abstract available.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textEBNEO Commentary: The impact of timing of inguinal hernia repair on outcomes in preterm infants.Sharma P, King B.Acta Paediatr. 2024 Jul 29. doi: 10.1111/apa.17361. Online ahead of print.PMID: 39073191 No abstract available. Effect of Early vs Late Inguinal Hernia Repair on Serious Adverse Event Rates in Preterm Infants: A Randomized Clinical Trial.HIP Trial Investigators; Blakely ML, Krzyzaniak A, Dassinger MS, Pedroza C, Weitkamp JH, Gosain A, Cotten M, Hintz SR, Rice H, Courtney SE, Lally KP, Ambalavanan N, Bendel CM, Bui KCT, Calkins C, Chandler NM, Dasgupta R, Davis JM, Deans K, DeUgarte DA, Gander J, Jackson CA, Keszler M, Kling K, Fenton SJ, Fisher KA, Hartman T, Huang EY, Islam S, Koch F, Lainwala S, Lesher A, Lopez M, Misra M, Overbey J, Poindexter B, Russell R, Stylianos S, Tamura DY, Yoder BA, Lucas D, Shaul D, Ham PB 3rd, Fitzpatrick C, Calkins K, Garrison A, de la Cruz D, Abdessalam S, Kvasnovsky C, Segura BJ, Shilyansky J, Smith LM, Tyson JE.JAMA. 2024 Mar 26;331(12):1035-1044. doi: 10.1001/jama.2024.2302.PMID: 38530261 Clinical Trial. Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textPaediatric intensive care admissions of preterm children born <32 weeks gestation: a national retrospective cohort study using data linkage.van Hasselt TJ, Gale C, Battersby C, Davis PJ, Draper E, Seaton SE; United Kingdom Neonatal Collaborative and the Paediatric Critical Care Society Study Group (PCCS-SG).Arch Dis Child Fetal Neonatal Ed. 2024 Apr 18;109(3):265-271. doi: 10.1136/archdischild-2023-325970.PMID: 37923384 Free PMC article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textWhat I Have Learned in the Last 24 Years Being Editor-in-Chief.Rivara FP.JAMA Pediatr. 2024 Sep 3. doi: 10.1001/jamapediatrics.2024.3288. Online ahead of print.PMID: 39226042 Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textMitigating Alarm Fatigue and Improving the Bedside Experience by Reducing Non-actionable Alarms.Yang JK, Su F, Graber-Naidich A, Hedlin H, Madsen N, DeSousa C, Feehan S, Graves A, Palmquist A, Cable R, Kipps AK.J Pediatr. 2024 Aug 29:114278. doi: 10.1016/j.jpeds.2024.114278. Online ahead of print.PMID: 39216620Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this episode of the Global Neonatal Podcast, hosts Mbozu and Shelly- Ann interview Dr. Gae Mundundu and Dr. Ritah Nazziwa, neonatal fellows in the African Paediatric Fellowship Program (APFP) at the University of Cape Town. During the conversation Dr. Mundundu and Dr Nazziwa  discuss neonatal services in their home countries of Zambia and Uganda, as well as their experiences as neonatal fellows. They highlight the challenges and opportunities in neonatal care in their respective countries, including the need for improved infrastructure and the importance of basic interventions. They also discuss the APFP which aims to empower African paediatricians and improve child health outcomes by providing specialized training and mentorship. Dr. Mundundu and Dr. Nazziwa also share about their day-to-day experiences as fellows, emphasizing the continuous learning process, the  practical application of knowledge and the diverse roles and responsibilities of a neonatology fellow.  Resources mentioned in episode:The African Paediatric  Fellowship Program: https://health.uct.ac.za/apfp/our-model-0Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!