The Incubator

Send us a textIn this engaging conversation, Dr. Emin Maltepe shares his journey as a neonatologist and physician scientist, discussing the serendipitous events that shaped his research interests, particularly in hypoxia and drug development for neonatology. He reflects on the importance of mentorship, the challenges of drug development in pediatrics, and the MD-PhD pathway, providing insights into the complexities of balancing clinical practice with research. In this conversation, Emin Maltepe discusses his journey through the MD-PhD program and how it shaped his career in pediatric drug development. He highlights the significant challenges faced in developing therapeutics for pediatric populations, particularly preterm infants, and the lack of attention and funding in this area. Emin shares insights into his innovative approaches to drug and device development, including collaborations with global organizations and the importance of using appropriate animal models. He emphasizes the need for policy advocacy and business knowledge in the field of pediatric therapeutics, while also reflecting on the personal challenges and rewards of balancing family life with a demanding career.Resources mentioned in episode:https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.048264https://journals.lww.com/shockjournal/fulltext/2024/07000/omx__a_novel_oxygen_delivery_biotherapeutic.14.aspxhttps://www.nature.com/articles/s41598-023-36653-9https://www.nature.com/articles/s41587-021-00866-yhttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005924Episode Webpage Link:Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this inaugural episode of our brand-new series, NeoNews, hosts Ben Courchia, Daphna Yasova Barbeau, and new team member Dr. Eli Cahan dive into articles from major news outlets like Rolling Stone, The Wall Street Journal, and The New York Times to unpack their relevance to neonatology, newborn care, and perinatology.Dr. Cahan, a pediatrician and aspiring neonatologist with a background in journalism, leads discussions on critical topics, including prenatal cannabis use and its impact on families, disparities in treatment for 22-week preemies, the neuroscience of "mom brain," rising rates of sudden infant death syndrome (SIDS) post-COVID, and the concerning state of maternity care deserts in the U.S.The episode concludes with quick updates on viral health concerns and a significant FDA meeting on probiotics for NEC prevention. Join us as we bring the latest news to the neonatal community in this exciting new format! Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textThis episode of the Global Neonatal Podcast features reflections from the Tiny Feet Big Steps Conference, highlighting the growth and impact of neonatal care initiatives in Africa. Dr. Steven Swanson and Dr. Margaret Nakaketo share insights on the importance of networking, quality improvement, and the future of neonatology in the region. The conversation emphasizes collaboration, the need for real-time translation in training, and the significance of engaging with healthcare systems and government for better newborn care.Resources mentioned in episode:Link to playlist from Tiny Feet Big Steps conference https://youtube.com/playlist?list=PL-94lDL-ozLatIqf_yQVHjubePerN7NGg&si=fgFOBLpWVP2w5Yy4Institute of Child Health Africa (ICHA) https://www.tanzanianchildren.comTiny Feet Big Steps Conference https://tinyfeetbigsteps.comEpisode Webpage Link: https://www.the-incubator.org/post/255-reflections-from-the-tiny-feet-big-steps-conference-in-arusha-tanzania-ft-dr-stephen-swaSupport the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this latest episode of The Incubator Podcast Journal Club, Ben and Daphna explore studies that may shift clinical practices in neonatal care. They begin with a study from India examining oral calcium phosphate as an adjunct to phototherapy in treating neonatal jaundice. This double-blind, randomized, placebo-controlled trial investigates how calcium phosphate may help reduce bilirubin levels by binding to unconjugated bilirubin in the gut, potentially minimizing the need for prolonged phototherapy. The findings suggest that calcium phosphate could lower phototherapy duration and decrease cases of rebound hyperbilirubinemia, offering a possible new approach for jaundiced newborns.The episode also covers an intriguing study on alternative treatments for persistent pulmonary hypertension of the newborn (PPHN). By comparing oral sildenafil to bosentan, this research sheds light on the potential of sildenafil to reduce PASP more efficiently, especially in resource-limited settings. The team discusses these insights and examines how they may influence care for PPHN cases worldwide. Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textThe who, when, and why of pacifier use.Mitev K, Frewin KL, Augustinova M, Niedenthal PM, Rychlowska M, Vanderwert RE.Pediatr Res. 2024 Oct 15. doi: 10.1038/s41390-024-03540-6. Online ahead of print.PMID: 39406952 Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textExpanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions.Ziegler A, Koval-Burt C, Kay DM, Suchy SF, Begtrup A, Langley KG, Hernan R, Amendola LM, Boyd BM, Bradley J, Brandt T, Cohen LL, Coffey AJ, Devaney JM, Dygulska B, Friedman B, Fuleihan RL, Gyimah A, Hahn S, Hofherr S, Hruska KS, Hu Z, Jeanne M, Jin G, Johnson DA, Kavus H, Leibel RL, Lobritto SJ, McGee S, Milner JD, McWalter K, Monaghan KG, Orange JS, Pimentel Soler N, Quevedo Y, Ratner S, Retterer K, Shah A, Shapiro N, Sicko RJ, Silver ES, Strom S, Torene RI, Williams O, Ustach VD, Wynn J, Taft RJ, Kruszka P, Caggana M, Chung WK.JAMA. 2024 Oct 24:e2419662. doi: 10.1001/jama.2024.19662. Online ahead of print.PMID: 39446378Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textEvaluation of efficacy of oral calcium phosphate as an adjunct to standard-of-care regular phototherapy in cases of neonatal jaundice: a hospital-based double-blind, randomised, placebo-controlled trial.Ghorui A, Chowdhry BK, Manjhi PK, Kumar P, Kumar CM.BMJ Paediatr Open. 2024 Oct 11;8(1):e002902. doi: 10.1136/bmjpo-2024-002902.PMID: 39395818 Free PMC article. Clinical Trial.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textOral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial.Kallimath A, Deshpande S, Singh P, Garegrat R, Lakshminrusimha S, Maheshwari R, Suryawanshi P.BMC Pediatr. 2024 Nov 1;24(1):698. doi: 10.1186/s12887-024-05107-0.PMID: 39487423 Free PMC article. Clinical Trial.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textGenetic disorders and their association with morbidity and mortality in early preterm small for gestational age infants.Bomback M, Everett S, Lyford A, Sahni R, Kim F, Baptiste C, Motelow JE, Tolia V, Clark R, Dugoff L, Hays T.Am J Obstet Gynecol. 2024 Sep 23:S0002-9378(24)01013-5. doi: 10.1016/j.ajog.2024.09.101. Online ahead of print.PMID: 39322018Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textInpatient Skin-to-skin Care Predicts 12-Month Neurodevelopmental Outcomes in Very Preterm Infants.Lazarus MF, Marchman VA, Brignoni-Pérez E, Dubner S, Feldman HM, Scala M, Travis KE.J Pediatr. 2024 Nov;274:114190. doi: 10.1016/j.jpeds.2024.114190. Epub 2024 Jul 14.PMID: 39004169Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!