Longevity Acceleration Podcast

Peter Fedichev, founder of Gero, and Aleksandr Sviridov dive into the intriguing world of longevity science. They discuss how physics can illuminate aging processes and the significance of creating standardized aging models. The conversation spans innovative data utilization, from plasma proteomics to wearable tech, in advancing anti-aging therapies. They also explore the exciting possibilities of epigenetic rejuvenation, organ replacement, and the collaborative efforts needed in the field to push boundaries, emphasizing prevention alongside repair.

In this engaging discussion, Alexander Fedintsev, Chief Science Officer at RLE Group and a researcher in aging and longevity, explores the complexities of the extracellular matrix (ECM) and its pivotal role in lifespan. He discusses the interplay between aging, DNA mutations, and clonal hematopoiesis, highlighting the immune system's decline. Fedintsev proposes revolutionary approaches to repairing the ECM and emphasizes the importance of elastin for overall health. The conversation also touches on the challenges of cryopreservation and the potential of innovative therapies for radical life extension.

Jean Hebert is a professor of genetics and neuroscience at the Albert Einstein College of Medicine. In this interview, he discusses his strategy of replacing ageing as a pathway to longevity, shifting focus from genetics to brain tissue replacement due to ageing complexities. He emphasizes the potential of gene delivery technology and brain replacement for longevity. The conversation covers tissue replacement, particularly cortical tissue, and other brain structures like the hypothalamus. Jean addresses surgery challenges, the need for improved techniques, and estimated costs of $3 to $10 billion. We also discuss reversible cryostasis, advancements in cryopreservation, and the ethical implications of brain replacement and destructive uploading, alongside strategies to attract talent and funding to the longevity field.

The podcast features Reason, the Co-founder of Repair Biotechnologies, discussing innovative approaches to combat aging, including targeting cholesterol buildup, challenges in gene therapy, financial hurdles in therapeutic advancements, body replacement possibilities, and genetic engineering. The conversation also delves into the impact of DNA damage, the potential of AI in anti-aging efforts, and envisions a future of immortality and cosmic exploration.

Imagine a world where aging can be beaten! The hosts dive into cutting-edge strategies like genetic modification and brain replacement. They explore innovative concepts such as biostasis, the process of halting biological decline. Personal stories illuminate the community's drive to create resources for longevity research, while a roadmap for tackling aging emerges as a pressing need. Future conversations with experts promise to unpack exciting advancements in bioengineering and longevity science!

A deep dive conversation with José Luis Ricon (Head of Theory @ Retro Bioscience, blogger @ Nintil.com). José explains his mental model for understanding aging and the strategies and technologies that could extend healthy lifespan by 10 years -- or much much more...