

#004: The Matrix of Aging: ECM, Longevity, and Radical Life Extension – Alexander Fedintsev (Chief Science Officer at RLE Group)
4 snips Jul 17, 2024
In this engaging discussion, Alexander Fedintsev, Chief Science Officer at RLE Group and a researcher in aging and longevity, explores the complexities of the extracellular matrix (ECM) and its pivotal role in lifespan. He discusses the interplay between aging, DNA mutations, and clonal hematopoiesis, highlighting the immune system's decline. Fedintsev proposes revolutionary approaches to repairing the ECM and emphasizes the importance of elastin for overall health. The conversation also touches on the challenges of cryopreservation and the potential of innovative therapies for radical life extension.
Chapters
Transcript
Episode notes
1 2 3 4 5 6 7 8 9 10 11
Intro
00:00 • 5min
Exploring the Complexities of Aging
05:06 • 7min
Exploring Biological Repair and Aging
12:15 • 17min
Aging and Hematopoietic Stem Cells
29:45 • 12min
Roadmap to Aging Research
41:24 • 17min
The Role of Elastin in Aging
58:30 • 7min
Exploring Radical Longevity through the Extracellular Matrix
01:05:12 • 19min
Cryopreservation Challenges and Possibilities
01:23:51 • 11min
Genetics and Longevity: Challenges and Innovations
01:34:31 • 21min
Collaborative Efforts in Radical Life Extension Research
01:55:35 • 2min
Exploring Innovative Approaches to Longevity and Health
01:57:49 • 2min