Senator Amy Klobuchar, a leading advocate for tech regulation and antitrust legislation, dives into her legislative battles against Big Tech and the challenges small companies face amidst monopolies like Google and Amazon. She discusses her determination to address children's online safety and the complexities of bipartisan efforts in Congress. Klobuchar also shares insights on navigating the political landscape post-January 6, the implications of Trump's nominations, and the urgent need for accountability in the tech sector.

Maggie Haberman, senior political correspondent for The New York Times and author of "Confidence Man," talks about Trump’s unexpected return to power. She dives into his upcoming policy moves, potential cabinet picks, and the heavy influence of figures like Elon Musk. Haberman discusses the dichotomy of Trump’s public persona and the ongoing challenges he poses to both political parties. With insights into threats against journalists and dissenters, she reveals the political dynamics at play as Trump navigates his next chapter.

Join Rumman Chowdry, the first U.S. Science Envoy for AI, Mark Dredze, a bias researcher from Johns Hopkins, and economist-turned-AI scholar Gillian Hadfield as they delve into AI's ethical minefield. They address the haunting question: can we create unbiased AI? The trio also discusses the frightening realities of AI under potential future administrations, the need for robust legal frameworks, and the risks of stifling innovation amid the AI hype. It’s a thought-provoking exploration of the urgent need for responsible AI development.

Samantha Bee, a comedian and former late-night host known for her Emmy-winning work on "Full Frontal with Samantha Bee," joins CNN correspondent Audie Cornish. They discuss Bee's surprising decision to be 'Democrat-celibate,' sharing her humorous take on stepping back from politics. The conversation dives into how comedy can address personal struggles and tackle the anxieties of constant news cycles. Bee also reflects on the evolving role of humor in today's political landscape, balancing escapism with the realities of divisive issues.

In this engaging discussion, Sarah Silverman, a fearless comedian known for her work on Saturday Night Live and Broadway, joins organizational psychologist Adam Grant. They dive into the power of kindness towards online trolls and the complexities of human relationships. Silverman shares her experiences of using humor as a defense mechanism, emphasizing empathy in tough conversations. The duo explores how compassion can transform conflicts and foster connections, shedding light on the importance of candid friendships that support and challenge.

This week features Dwight Garner, a seasoned book critic from The New York Times, and Becca Rothfeld from The Washington Post, both passionate about literature. They discuss the merits and pitfalls of bestsellers, dive into the joy of physical books amid digital trends, and contemplate rising book censorship. With a critical eye, they explore how modern literature reflects generational divides and personal narratives. Their insights promise new favorites and thoughtful critiques on what might become the timeless classics of 2024.

Yann LeCun, Chief AI Scientist at Meta and a pioneer in neural networks, engages in a lively discussion about open-source AI. He shares insights on the financial race in AI, where tech giants invest heavily in advancements. Yann tackles the risks of open-sourcing powerful models and advocates for guidelines to ensure ethical development. He also voices his thoughts on AI regulation and explains the necessity of transparency in research. Known for his candidness, he isn’t shy about sharing his views on figures like Elon Musk and Donald Trump.

Dr. Zeke Emanuel, an architect of the Affordable Care Act, Dr. Celine Gounder, an infectious disease specialist, and Donald McNeil Jr., a former NY Times health reporter, dive into the implications of RFK Jr.'s controversial nomination for the Department of Health and Human Services. They explore the rise of COVID denialism, the complex anti-vaccine movement, and the impact of political beliefs on public health strategies. The conversation emphasizes the necessity of science-based decision-making amidst a shifting landscape of health policies.

Matty Matheson, a Canadian chef, restaurateur, and star of 'The Bear,' shares his culinary journey, from executive producing to acting in a beloved series. He candidly discusses the emotional highs and lows of cooking for family and the delightful chaos that culinary creativity brings. Matheson highlights the importance of community in cooking and reflects on his role in empowering Indigenous culinary students. With humor and warmth, he underscores the value of comfort food and the evolving paths for chefs in today's landscape.

In this discussion, U.S. Representative Ro Khanna, known for his progressive populism, emphasizes the need to unite tech leaders and working-class advocates. He delves into AI policy and the Kids Online Safety Act, critiquing emotional rhetoric around social media regulations. Khanna also reflects on the Democratic Party's challenges, advocating for economic reforms and a safety net to combat inequality. Additionally, he underscores the importance of tech accountability, addressing the complexities of campaign financing and the influence of billionaires in politics.