Daily Value

In this episode of Daily Value, we look at science of Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR), two NAD+ precursors gaining traction in longevity research. Both supplements aim to restore NAD+ levels, critical for energy metabolism and cellular repair, yet their distinct pathways and tissue-specific effects suggest considerations for choosing one over the other.Discussion Points:-The metabolic pathways of NMN and NR, highlighting how their mechanisms of action influence NAD+ synthesis across tissues.-Insights from a 2024 study (in rodents - PMID: 38645109) demonstrating the dual effects of NMN: improvements in cardiac and liver function, alongside kidney inflammation linked to toxic metabolite accumulation at high doses.-Clinical dosing strategies, safety considerations, and how age and tissue-specific needs may guide the choice between NMN and NR.https://pubmed.ncbi.nlm.nih.gov/38645109/ https://iadns.onlinelibrary.wiley.com/doi/10.1002/fft2.511 

In this episode of Daily Value, we delve into the emerging evidence surrounding Urolithin A, a metabolite derived from gut bacteria that is showing potential for enhancing athletic performance and recovery in young healthy populations. Originating from dietary ellagitannins found in foods such as pomegranates, berries, and nuts, but also available as a supplement, Urolithin A’s ability to optimize mitochondrial function suggests new approaches to sports nutrition and physical performance.Discussion Points:-The mechanisms of Urolithin A, including its role in activating mitophagy to improve mitochondrial efficiency.-Insights from recent clinical trials using supplemental Urolithin A, demonstrates its impact on strength, endurance, and markers of recovery, including inflammation and protein breakdown.-The broader implications of Urolithin A for resistance-trained individuals and populations at risk of muscle decline.https://pubmed.ncbi.nlm.nih.gov/39487653/

Dive into the fascinating world of Vitamin D and its profound effects on muscle health and energy metabolism. Discover how this secosteroid plays a crucial role in muscle protein synthesis and strength. The discussion includes insights on Vitamin D deficiency and its impact across ages, along with the science behind myostatin inhibition for muscle growth. Learn about clinical trials highlighting the benefits of Vitamin D for athletes and older adults, and why monitoring levels is vital, especially during winter.

Discover how dietary fiber not only aids in digestion but also enhances the immune system by boosting B vitamin production from gut bacteria. Learn about new research illustrating the crucial role of fiber in maintaining gut health and regulating immunity. Uncover strategies for optimizing your diet to promote a healthy microbiome, and see how fiber deprivation can disrupt this balance. These insights may change your perspective on nutrition and the importance of gut health for overall well-being.

In today’s episode of Daily Value, we continue our exploration of vitamins by diving into the concept of hypovitaminosis and the importance of adequate vitamin intake for overall health. The second half of the 20th century brought critical insights into how vitamin insufficiencies, or hypovitaminosis, can impact human health, even in populations where outright deficiencies are uncommon. We’ll explore the distinction between insufficiency and deficiency, how vitamin status is assessed, and the risks associated with marginal deficiencies that may affect up to 31% of the U.S. population.Episode Talking Points:*The difference between vitamin insufficiency, deficiency, and clinical manifestations.*How socioeconomic factors and dietary choices can lead to hypovitaminosis, even in developed countries.*The role of biomarkers in diagnosing vitamin deficiencies and the limitations of current testing methods.

In today’s episode of Daily Value, we look at the protective effects of coffee, tea, and caffeine consumption on cardiometabolic health. A recent study published in the Journal of Clinical Endocrinology & Metabolism (doi:10.1210/clinem/dgae552) reveals how moderate caffeine intake—equivalent to a specific amount of caffeine—is related to the reduced risk of cardiometabolic multimorbidity, which includes coexistence of conditions like type 2 diabetes, coronary heart disease, and stroke.Episode Talking Points:*The link between caffeine intake and reduced risk of developing cardiometabolic diseases.*Potential mechanisms of protection, including antioxidant and anti-inflammatory effects, improved lipid metabolism, and the role of specific compounds like chlorogenic acid and catechins.*Practical takeaways for incorporating moderate coffee or tea consumption into your daily routine for long-term heart health.https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae552/7754545?redirectedFrom=fulltext

In today’s episode of Daily Value, we begin a special series called “The Vitamins,” where we’ll dive deep into the discovery, functions, and importance of vitamins in human health. This first episode lays the groundwork by exploring the history of vitamin discovery, from the 19th-century realization that certain diseases were tied to diet, to the revolutionary concept of vitamins and their role in preventing specific deficiency diseases. We’ll also cover key definitions, the defined physiological functions of vitamins, thereby allowing us to better understand how they impact our daily health.Episode Talking Points:The historical context of vitamin discovery and how it changed the course of nutrition science.Defining vitamins: their essential role, how they differ from macronutrients, and the five-part definition of what makes a vitamin.The functions of vitamins in the body, from acting as coenzymes and antioxidants to influencing gene transcription.Tune in to gain a deeper understanding of vitamins and their critical role in supporting overall health.

In today’s episode of Daily Value, we take a closer look at a commonly overlooked but essential nutrient: vitamin B12. Known as cobalamin, vitamin B12 deficiency can lead to severe neurological, hematological, and cognitive issues if left unchecked. We’ll cover the causes behind this growing issue, from dietary intake to malabsorption.Episode Talking Points:The role of B12 in nervous system function and red blood cell production.Causes of B12 deficiency, including dietary factors, autoimmune conditions, and genetic predispositions.Treatment approaches, including supplementation methods and the importance of early diagnosis.https://pubmed.ncbi.nlm.nih.gov/38987879/ https://www.nature.com/articles/nrdp201740

 In today’s episode of Daily Value, we explore the relationship between magnesium supplementation and blood pressure management. Although past research has produced mixed results, a recent umbrella meta-analysis (PMID: 39280209) has provided new insights into the impact of magnesium on cardiovascular health. With hypertension being a major risk factor for heart disease and stroke, understanding how magnesium can help regulate blood pressure is more important than ever.Episode Talking Points:The statistical importance of lowering blood pressure on cardiovascular and kidney disease risk.The role of magnesium in calcium regulation, muscle function, and vascular tone, and how it supports healthy blood pressure levels.Findings from a recent umbrella meta-analysis (PMID: 39280209) showing reductions in systolic and diastolic blood pressure with certain doses for a specific length of time.https://www.sciencedirect.com/science/article/pii/S0011393X24000250 

In today’s episode of Daily Value, we explore the complex and ever-evolving topic of Traumatic Brain Injuries (TBIs), with a focus on new findings related to nutritional support and recovery. TBIs are often referred to as "invisible injuries" due to their [at times] subtle presentation, but they can have long-lasting effects on brain health and function. Recent research suggests that targeted supplementation may aid in recovery and even mitigate some of the long-term impacts of TBIs. Episode Talking Points:*Mechanisms of TBI pathology, including primary and secondary injury phases that affect brain metabolism, neuroinflammation, and energy production.*Highlighting a recently published narrative review paper (PMID: 39125311) suggesting nutritional interventions that may offer neuroprotection if used peri-TBI.*The role of creatine supplementation in maintaining ATP levels during recovery.*How omega-3 fatty acids in certain doses, particularly DHA, may promote brain repair/recovery.*Other nutrient strategies that show promise in supporting brain health post-TBI.https://www.mdpi.com/2072-6643/16/15/2430